接触颗粒物与多发性硬化症的关系:系统回顾和荟萃分析。

IF 2.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2022-01-01 Epub Date: 2021-06-16 DOI:10.1159/000516559

Fatemeh Lotfi, Marjan Mansourian, Omid Mirmoayyeb, Soroush Najdaghi, Vahid Shaygannejad, Nafiseh Esmaeil

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引用次数: 2

摘要

空气污染与多发性硬化症(MS)之间的关系尚不完全清楚。该荟萃分析旨在确定颗粒物(PM)2.5、PM10与MS发病率/复发之间的相关性。在EMBASE、Web of Science、PubMed和灰色文献中进行文献检索。16篇文章被检索，10篇文章被纳入并评价。meta分析使用了三种关联指标:优势比(横断面和病例对照研究)、发病率比或风险比(队列研究)。对这3项PM2.5研究的荟萃分析表明，暴露于PM2.5与MS复发和发病率相关(95%可信区间;CI] 1.178 [1.102, 1.279])， p > 0.05。此外，所有研究的风险比评估显示pm (PM10和PM2.5)与MS发病率和复发之间存在相关性([95% CI] 1.28， [1.13-1.43]) p < 0.05。总的来说，我们发现MS患者的PM暴露(PM10和PM2.5)与疾病的发生和复发有关。

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Association of Exposure to Particulate Matters and Multiple Sclerosis: A Systematic Review and Meta-Analysis.

The association between air pollution and multiple sclerosis (MS) is not entirely clear. This meta-analysis was aimed at determining the correlation between particulate matter (PM)2.5, PM10, and MS incidence/relapse. The literature search was performed in EMBASE, Web of Science, PubMed, and the gray literature. Sixteen articles were retrieved, and ten articles were included and evaluated. Three measures of association were used for the meta-analysis: odds ratio (cross-sectional and case-control studies), incidence rate ratio, or hazard ratio (cohort studies). Meta-analysis of those 3 studies on PM2.5 indicated that exposure to PM2.5 was associated with MS relapse and incidence ([95% confidence interval; CI] 1.178 [1.102, 1.279]), p > 0.05. Also, assessment of risk ratio for all studies showed a correlation between PMs (PM10 and PM2.5) and MS incidence and relapse ([95% CI] 1.28, [1.13-1.43]) p < 0.05. Collectively, we found that PM exposure (PM10 and PM2.5) in MS patients associates with the occurrence and relapse of disease.

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.