接受胃旁路手术的肥胖患者的人体测量与糖代谢和心血管风险的相关性。

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Journal of Obesity Pub Date : 2021-07-16 eCollection Date: 2021-01-01 DOI:10.1155/2021/6647328
Erica Aldenbäck, Hans-Erik Johansson
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引用次数: 3

摘要

腹部肥胖与高血压、空腹血糖、糖化血红蛋白和胆固醇升高有关。身体质量指数(BMI)经常被用来衡量和定义肥胖,并作为减肥手术的纳入标准。矢状腹直径(SAD)被认为比BMI更能预测内脏脂肪的数量、代谢特征和心脏代谢风险。目的是测试与BMI相比,SAD是否与糖代谢特征有更强的相关性。155名(108名女性,47名男性)接受减肥手术的病态肥胖患者在Roux-en-Y胃旁路手术(RYGBP)前(基线)、6个月和12个月进行了评估。BMI从43.7 kg/m2(基线)降至31.3 kg/m2(12个月),SAD从32.6降至23.2 cm(均pp=0.04),空腹血糖(p=0.008)、糖化血红蛋白(p=0.016)、甘油三酯(p=0.017)、收缩压(p=0.032)和维生素D (p=0.027)。BMI与CRP (p=0.006)、甘油三酯(p=0.016)、维生素D (p=0.002)和镁(p=0.037)相关。尽管进行了RYGBP手术,维生素D仍显著增加。RYGBP后肝酶显著降低,SAD随时间的变化与γ -谷氨酰转移酶相关。SAD在预测血糖紊乱和血脂异常方面优于BMI,这意味着SAD的使用增加,因为它在临床中成本有效且操作简单,在考虑患者进行减肥手术时可能有价值。
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Anthropometric Measurements and Correlations to Glucometabolic and Cardiovascular Risk in Obese Patients Undergoing Gastric Bypass Surgery.

Abdominal obesity is associated with hypertension, increased fasting glucose, HbA1c, and cholesterol. Body mass index (BMI) is frequently used to measure and define obesity and as inclusion criteria for bariatric surgery. Sagittal abdominal diameter (SAD) has been suggested to predict the amount of visceral fat, metabolic traits, and cardiometabolic risk superior to BMI. The aim was to test whether SAD has stronger correlations to glucometabolic traits compared to BMI. One hundred and fifty-five (108 women, 47 men) morbidly obese patients undergoing bariatric surgery were evaluated before (baseline), 6 and 12 months after Roux-en-Y gastric bypass (RYGBP). BMI was reduced from 43.7 kg/m2 (baseline) to 31.3 kg/m2 (12 months) and SAD from 32.6 to 23.2 cm (both p<0.001). SAD correlated with CRP (p=0.04), fasting glucose (p=0.008), HbA1c (p=0.016), triglycerides (p=0.017), systolic blood pressure (p=0.032), and vitamin D (p=0.027). BMI correlated with CRP (p=0.006), triglycerides (p=0.016), vitamin D (p=0.002), and magnesium (p=0.037). Despite RYGBP surgery, vitamin D was significantly increased. Liver enzymes were significantly lowered after RYGBP and the change over time in SAD correlated with gamma-glutamyltransferase. SAD was superior to BMI to predict glucose disturbance and dyslipidemia implying increased use of SAD as it is cost effective and simple to perform in the clinic and could be of value when considering patients for bariatric surgery.

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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
期刊最新文献
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