纳米配方和眼科药物输送系统临床研究的重点:综述。

IF 3 4区 医学 Q2 PHARMACOLOGY & PHARMACY Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2021035767
Munira M Momin, Shaikh Darakhshan Afreen
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引用次数: 6

摘要

几种眼部给药系统,如水凝胶、微颗粒、纳米乳剂、微乳剂和脂质体,已经被研究过,它们可以控制药物的释放,并在眼内延迟一段时间维持治疗水平。而新的药物靶向方法是通过各种纳米粒子来实现的。目前在市场上,对新型纳米眼给药系统的选择和需求较少,并且需要延长前、后眼段给药的治疗方法。本文的主要目的是总结目前在ODD中不同纳米和微系统的发现和已证实的活性。本文还描述了一些法规更新以及授予发明人在ODD上的工作的专利。综上所述,本文对如何利用纳米粒子和纳米医学等不同的纳米技术来研究ODD和治疗的前沿进行了思考。
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Nanoformulations and Highlights of Clinical Studies for Ocular Drug Delivery Systems: An Overview.

Several ocular drug delivery (ODD) systems, like hydrogels, microparticles, nano-emulsions, micro-emulsions, and liposomes have been researched, which can govern the drug release and sustain therapeutic levels for a delayed period in the eye. While new drugs targeting methods to the eye are possible by various nanoparticles. Presently in the market, there are fewer choices and need for novel nano-ocular delivery systems as well as therapies for prolonged delivery to the anterior and posterior eye segments. The primary objective of this article is to summarize current discoveries and proven activities of different nano- and microsystems in ODD. This article also depicts some regulatory updates along with the patents granted to the inventor for their work on ODD. Overall, a thought of how the different forthcoming of nanotechnologies like nanoparticles and nanomedicine can be used to investigate the frontiers of ODD and treatment can be withdrawn by this article.

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来源期刊
CiteScore
5.50
自引率
18.50%
发文量
27
审稿时长
>12 weeks
期刊介绍: Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.
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