探索卫星dna:双壳类软体动物基因组的特异性。

Eva Šatović Vukšić, Miroslav Plohl
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引用次数: 4

摘要

串联重复的非编码DNA序列或卫星DNA构成每个真核生物基因组的组成部分。随着时间的推移,新方法的发展和应用使人们对这些序列的结构和功能作用的理解逐渐提高,这些序列早期被误认为是“垃圾DNA”。先进的方法开始增加对它们在基因组尺度上存在的细节的新见解,由于在分析卫星DNA几乎相同的串联重复序列的长阵列方面存在困难,传统上很难获得这些细节。反过来,开阔的视野为卫星DNA生物学新概念的发展开辟了空间,也突出了来自不同生物群体的特异性。观察到这些序列在不同方面和组织形式的多样性,表明需要一个多用途的模式生物库。双壳类软体动物是一种重要的海洋和淡水生物,其基因组中卫星dna的独特性增加了组织原理的多样性和相关作用,其中串联重复序列对基因组的贡献。
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Exploring Satellite DNAs: Specificities of Bivalve Mollusks Genomes.

Noncoding DNA sequences repeated in tandem or satellite DNAs make an integral part of every eukaryotic genome. Development and application of new methodological approaches through time enabled gradual improvement in understanding of structural and functional roles of these sequences, early misconsidered as "junk DNA". Advancing approaches started adding novel insights into details of their existence on the genomic scale, traditionally hard to access due to difficulties in analyzing long arrays of nearly identical tandem repeats of a satellite DNA. In turn, broadened views opened space for the development of new concepts on satellite DNA biology, highlighting also specificities coming from different groups of organisms. Observed diversities in different aspects and in organizational forms of these sequences proclaimed a need for a versatile pool of model organisms. Peculiarities of satellite DNAs populating genomes of bivalve mollusks, an important group of marine and fresh-water organisms, add to the diversity of organizational principles and associated roles in which tandemly repeated sequences contribute to the genomes.

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来源期刊
CiteScore
3.30
自引率
0.00%
发文量
7
期刊介绍: Molecular biology has been providing an overwhelming amount of data on the structural components and molecular machineries of the cell and its organelles and the complexity of intra- and intercellular communication. The molecular basis of hereditary and acquired diseases is beginning to be unravelled, and profound new insights into development and evolutionary biology have been gained from molecular approaches. Progress in Molecular and Subcellular Biology summarises the most recent developments in this fascinating area of biology.
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