Deniz Kilic , Berkay Akmaz , Fahrettin Akay , Yusuf Ziya Guven , Guzide Gonca Oruk
{"title":"肢端肥大症患者前段参数的变化和干眼病的存在:一项天狼星地形图研究结合meibography","authors":"Deniz Kilic , Berkay Akmaz , Fahrettin Akay , Yusuf Ziya Guven , Guzide Gonca Oruk","doi":"10.1016/j.ghir.2021.101424","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p><span>To investigate anterior segment parameters (ASPs) and dry eye disease (DED), including the status of the meibomian glands, </span>in patients<span> with acromegaly.</span></p></div><div><h3>Methods</h3><p><span>In this cross-sectional, comparative study, 36 acromegaly patients and 40 healthy sex- and age-matched controls were included. Participants received a comprehensive ophthalmological examination, including intraocular pressure<span> measurements with Goldmann applanation tonometry (IOP</span></span><sub>GAT</sub>) and central corneal thickness corrected intraocular pressure (IOP<sub>CCT</sub><span>) measurements, and were evaluated for ASPs and DED. For ASPs, white-to-white (WTW), apical (ACT) and thinnest corneal thickness (TCT), corneal volume (CV), keratometry readings (K</span><sub>1</sub>, K<sub>2</sub>, and K<sub>mean</sub><span><span><span>), anterior chamber depth (ACD) and volume (ACV), and iridocorneal angle (ICA) were obtained via Sirius topography. DED was assessed with Schirmer's test, tear breakup time (TBUT), and </span>Ocular Surface Disease Index (OSDI) scores. </span>Meibography scores (MSs) were obtained with the Sirius topography device.</span></p></div><div><h3>Results</h3><p>Patients had higher mean IOP<sub>GAT</sub> (<em>P</em> = .006), IOP<sub>CCT</sub> (<em>P</em> = .01), ACT (<em>P</em> = .024), and TCT (<em>P</em> = .005) but narrower ICA (<em>P</em> = .014) than controls. Although Schirmer's test did not differ between the groups (<em>P</em> = .442), patients had higher OSDI (<em>P</em> < .001), higher MS (<em>P</em> = .001), and shorter TBUT (<em>P</em> = .002).</p></div><div><h3>Conclusion</h3><p>Patients with acromegaly have greater IOP, greater corneal thickness, but narrower ICA than healthy individuals, as well as DED with increased MSs, which suggests meibomian gland dysfunction.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101424","citationCount":"2","resultStr":"{\"title\":\"Changes in anterior segment parameters and presence of dry eye disease in patients with acromegaly: A Sirius topography study combined with meibography\",\"authors\":\"Deniz Kilic , Berkay Akmaz , Fahrettin Akay , Yusuf Ziya Guven , Guzide Gonca Oruk\",\"doi\":\"10.1016/j.ghir.2021.101424\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p><span>To investigate anterior segment parameters (ASPs) and dry eye disease (DED), including the status of the meibomian glands, </span>in patients<span> with acromegaly.</span></p></div><div><h3>Methods</h3><p><span>In this cross-sectional, comparative study, 36 acromegaly patients and 40 healthy sex- and age-matched controls were included. Participants received a comprehensive ophthalmological examination, including intraocular pressure<span> measurements with Goldmann applanation tonometry (IOP</span></span><sub>GAT</sub>) and central corneal thickness corrected intraocular pressure (IOP<sub>CCT</sub><span>) measurements, and were evaluated for ASPs and DED. For ASPs, white-to-white (WTW), apical (ACT) and thinnest corneal thickness (TCT), corneal volume (CV), keratometry readings (K</span><sub>1</sub>, K<sub>2</sub>, and K<sub>mean</sub><span><span><span>), anterior chamber depth (ACD) and volume (ACV), and iridocorneal angle (ICA) were obtained via Sirius topography. DED was assessed with Schirmer's test, tear breakup time (TBUT), and </span>Ocular Surface Disease Index (OSDI) scores. </span>Meibography scores (MSs) were obtained with the Sirius topography device.</span></p></div><div><h3>Results</h3><p>Patients had higher mean IOP<sub>GAT</sub> (<em>P</em> = .006), IOP<sub>CCT</sub> (<em>P</em> = .01), ACT (<em>P</em> = .024), and TCT (<em>P</em> = .005) but narrower ICA (<em>P</em> = .014) than controls. Although Schirmer's test did not differ between the groups (<em>P</em> = .442), patients had higher OSDI (<em>P</em> < .001), higher MS (<em>P</em> = .001), and shorter TBUT (<em>P</em> = .002).</p></div><div><h3>Conclusion</h3><p>Patients with acromegaly have greater IOP, greater corneal thickness, but narrower ICA than healthy individuals, as well as DED with increased MSs, which suggests meibomian gland dysfunction.</p></div>\",\"PeriodicalId\":12803,\"journal\":{\"name\":\"Growth Hormone & Igf Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101424\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Hormone & Igf Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096637421000472\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637421000472","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Changes in anterior segment parameters and presence of dry eye disease in patients with acromegaly: A Sirius topography study combined with meibography
Purpose
To investigate anterior segment parameters (ASPs) and dry eye disease (DED), including the status of the meibomian glands, in patients with acromegaly.
Methods
In this cross-sectional, comparative study, 36 acromegaly patients and 40 healthy sex- and age-matched controls were included. Participants received a comprehensive ophthalmological examination, including intraocular pressure measurements with Goldmann applanation tonometry (IOPGAT) and central corneal thickness corrected intraocular pressure (IOPCCT) measurements, and were evaluated for ASPs and DED. For ASPs, white-to-white (WTW), apical (ACT) and thinnest corneal thickness (TCT), corneal volume (CV), keratometry readings (K1, K2, and Kmean), anterior chamber depth (ACD) and volume (ACV), and iridocorneal angle (ICA) were obtained via Sirius topography. DED was assessed with Schirmer's test, tear breakup time (TBUT), and Ocular Surface Disease Index (OSDI) scores. Meibography scores (MSs) were obtained with the Sirius topography device.
Results
Patients had higher mean IOPGAT (P = .006), IOPCCT (P = .01), ACT (P = .024), and TCT (P = .005) but narrower ICA (P = .014) than controls. Although Schirmer's test did not differ between the groups (P = .442), patients had higher OSDI (P < .001), higher MS (P = .001), and shorter TBUT (P = .002).
Conclusion
Patients with acromegaly have greater IOP, greater corneal thickness, but narrower ICA than healthy individuals, as well as DED with increased MSs, which suggests meibomian gland dysfunction.
期刊介绍:
Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.