伊拉克炼油厂工人重金属含量及其对抗氧化剂和生理参数的影响

IF 2.4 Q1 Medicine Journal of Health and Pollution Pub Date : 2021-08-17 eCollection Date: 2021-09-01 DOI:10.5696/2156-9614-11.31.210907
Mohammed A Ajeel, Akram A Ajeel, Aws Maseer Nejres, Riyam Ameen Salih
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引用次数: 5

摘要

背景:一些重金属如锌(Zn)和镁(Mg)在高剂量时可能对人体健康有害,而其他重金属如铅(Pb)、镉(Cd)、汞(Hg)和铜(Cu)即使是小剂量也会对健康造成有害后果。原油中加入重金属和添加剂以提高性能。众所周知,原油中含有Cu、Cd、Ni和pb等重金属。目的:本研究旨在评估伊拉克炼油厂工人血清中重金属水平及其对抗氧化水平和生理变量的影响。方法:采用原子吸收光谱法(AAS)测定40例炼油厂工人和20例对照组血清中Pb、Cd、Hg、Zn、Cu、Mg等重金属含量。此外,还测量了丙二醛(MDA)、δ-氨基乙酰丙酸脱水酶(ALAD)和总抗氧化能力(TAC)水平,以及血液尿素、血清肌酐、谷氨酸-草酰转氨酶(GOT)、谷氨酸-丙酮转氨酶(GPT)和γ -谷氨酰转移酶(GGT)等生理变量,以评估这些重金属的影响。结果:与对照组相比,炼油厂工人组汞、Cd、Pb含量明显升高,而锌、Cu、Mg含量明显低于对照组。在大多数抗氧化剂和功能变量方面,对照组和工人组之间存在显著差异。总抗氧化能力(TAC)、δ-氨基乙酰丙酸脱水酶(ALAD)和丙二醛(MDA)在工人组显著降低,而血尿素、血清肌酐、谷氨酸丙酮酸转氨酶(GPT)和γ -谷氨酰转移酶(GGT)在工人组显著升高。谷草转氨酶(GOT)在对照组和工人组之间无显著差异。结论:与对照组相比,炼油厂工人血清中Pb、Cd和Hg水平升高的风险更高,这可能导致氧化应激增加,TAC降低,必需微量元素Zn、Cu和Mg减少。参与者同意:已获取。伦理批准:本研究已获得伊拉克摩苏尔尼尼微卫生部伦理委员会的批准。利益竞争:作者声明没有经济利益竞争。
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Assessment of Heavy Metals and Related Impacts on Antioxidants and Physiological Parameters in Oil Refinery Workers in Iraq.

Background: Some heavy metals can be harmful to human health in elevated doses such as zinc (Zn) and magnesium (Mg), while others such as lead (Pb), cadmium (Cd), mercury (Hg), and copper (Cu) have harmful consequences to health even in small doses. Heavy metals and additives are incorporated into crude oil to enhance performance.3,4,5 Crude oil is well known to contain heavy metals like Cu, Cd, Ni and Pb.3,6,7.

Objective: The current study aimed to assess levels of heavy metals and the impact of these metals on antioxidant levels and physiological variables in the serum of oil refinery workers in Iraq.

Methods: Heavy metals such as Pb, Cd, Hg, Zn, Cu and Mg were assessed in the serum of a sample of refinery workers (N=40) and a control group (N=20) using atomic absorption spectrometry (AAS). Additionally, levels of malondialdehyde (MDA), δ-aminolaevulinic acid dehydratase (ALAD) and total antioxidant capacity (TAC), and physiological variables such as blood urea, serum creatinine, glutamate-oxaloacetic transaminase (GOT), glutamate-pyruvic transaminase (GPT), and gamma-glutamyl transferase (GGT) were measured to assess impact of these heavy metals.

Results: Mercury, Cd, and Pb were significantly elevated in the refinery worker group in comparison with the control group, while the levels of Zn, Cu, and Mg were significantly lower in the refinery worker group compared to the control group. There was a significant difference between the control group and the worker group for most of the antioxidants and functional variables. Total antioxidant capacity (TAC), δ-aminolevulinic acid dehydratase (ALAD), and malondialdehyde (MDA) were significantly lower in the worker group while blood urea, serum creatinine, glutamate pyruvate transaminase (GPT), and gamma-glutamyl transferase (GGT) showed a significant elevation in the workers' group. Glutamic oxaloacetic transaminase (GOT) showed no significant difference between the control group and the worker group.

Conclusions: Refinery workers are at increased risk of having higher serum levels of Pb, Cd, and Hg compared to controls which can lead to an increase in oxidative stress, decrease in TAC, and decrease in the essential trace elements Zn, Cu and Mg.

Participant consent: Obtained.

Ethics approval: This study was approved by the ethics committee within the Nineveh Health Department, Mosul, Iraq.

Competing interests: The authors declare no competing financial interests.

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来源期刊
Journal of Health and Pollution
Journal of Health and Pollution Medicine-Public Health, Environmental and Occupational Health
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期刊介绍: The Journal of Health and Pollution (JH&P) was initiated with funding from the European Union and World Bank and continues to be a Platinum Open Access Journal. There are no publication or viewing charges. That is, there are no charges to readers or authors. Upon peer-review and acceptance, all articles are made available online. The high-ranking editorial board is comprised of active members who participate in JH&P submissions and editorial policies. The Journal of Health and Pollution welcomes manuscripts based on original research as well as findings from re-interpretation and examination of existing data. JH&P focuses on point source pollution, related health impacts, environmental control and remediation technology. JH&P also has an interest in ambient and indoor pollution. Pollutants of particular interest include heavy metals, pesticides, radionuclides, dioxins, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), air particulates (PM10 and PM2.5), and other severe and persistent toxins. JH&P emphasizes work relating directly to low and middle-income countries, however relevant work relating to high-income countries will be considered on a case-by-case basis.
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