替马洛尔-多唑胺固定联合治疗新诊断开角型青光眼的疗效和安全性:每日3次vs每日2次。

IF 2.4 Journal of Drug Assessment Pub Date : 2021-08-23 eCollection Date: 2021-01-01 DOI:10.1080/21556660.2021.1967642
Mohammad Pakravan, Afsaneh Naderi Beni, Shahin Yazdani, Hamed Esfandiari, Shahram Mirshojaee
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引用次数: 2

摘要

目的:比较多唑胺/替洛尔固定联合治疗新发原发性开角型青光眼(POAG)的疗效和安全性。方法:在这个前瞻性的介入病例系列中,纳入了新发POAG患者。患者开始服用coopt,每天两次(BID),持续一个月,然后改为每天三次(TDS),再持续一个月。患者在基线、第1个月(BID)和第2个月(TDS)时接受全面眼科检查、每日眼压(IOP)、血压(BP)和24小时心率(HR)测量。在整个研究过程中,研究人员对所有不良事件进行了监测。结果:31例POAG患者完成研究,平均基线IOP为23.1±3.15 mmHg。1个月时IOP显著降低(16.5±2.21)(p p p = 0.0004)。而coopt BID较基线显著降低了平均24小时收缩压和平均24小时HR (p p = 0.62)。结论:在安全性相当的POAG患者中,coopt TDS比coopt BID具有更好的降低眼压的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Efficacy and safety of timolol-dorzolamide fixed-combination three times a day versus two times a day in newly diagnosed open-angle glaucoma.

Objective: This study aimed to compare the therapeutic efficacy and safety of dorzolamide/timolol fixed-combination(Cosopt) in newly diagnosed primary open-angle glaucoma (POAG) patients.

Methods: In this prospective, interventional case series, newly POAG patients were included. Patients were started on Cosopt twice a day (BID) for one month and then switched to three times a day (TDS) for an additional month. Patients underwent comprehensive ophthalmic examination, diurnal intraocular pressure (IOP), blood pressure (BP), and 24-h heart rate (HR) measurements at baseline, month 1(BID), and month 2(TDS). Throughout the study, all adverse events were monitored by the investigators.

Results: In 31 POAG patients that completed the study, the mean baseline IOP was 23.1 ± 3.15 mmHg. IOP was decreased significantly 16.5 ± 2.21 at one month (p < .0001) and 13.9 ± 2.23 mmHg at 1 and 2 months follow up (p < .0001). IOP was significantly lower in month 2 compared to month 1 (p = .0004). While Cosopt BID significantly reduced the mean 24-h systolic BP and mean 24-h HR from baseline (p < .0001), the mean 24-h systolic BP and HR remained unchanged with Cosopt TDS compared to BID (p = .62).

Conclusions: Cosopt TDS has a superior IOP-lowering effect than Cosopt BID in POAG patients with comparable safety profiles.

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Journal of Drug Assessment
Journal of Drug Assessment PHARMACOLOGY & PHARMACY-
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