68Ga和18F的小靶标可重复性:靶标浓度和成像时间对临床相关幻影中SUV测量的影响

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING American journal of nuclear medicine and molecular imaging Pub Date : 2021-08-15 eCollection Date: 2021-01-01
Michael S Silosky, Luke W Patten, Bennett B Chin
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引用次数: 0

摘要

使用PET成像定量肿瘤摄取对评估治疗反应很重要。对于18F FDG PET扫描,摄取变化25%通常被认为是显著的。对于使用新型放射性药物的扫描,意义阈值尚不清楚。包括成像时间、肿瘤大小、活性浓度和放射性药物在内的因素可能会影响摄取指标的可重复性。本研究使用18F和68Ga模型,评估了这些参数对最大SUV (SUVmax)和平均SUV (SUVmean)可重复性的影响。使用18F和68Ga在Biograph Horizon PET/CT扫描仪(Siemens Medical Solutions, Malvern PA)上扫描Esser PET幻影(Data Spectrum, Durham NC)。数据采集时间为5分钟,重建时间为0.5-5分钟。背景活动模拟临床扫描,靶与背景(T/B)比值为1.7-19.8。测量5个切片的SUVmax和SUVmean。计算平均值、标准差和变异系数(COV)。使用多变量伽玛回归评估放射性核素、成像时间、活性浓度和靶标大小对冠状病毒的影响。SUVmax和SUVmean的COV值分别比18F高40%和54%。病变大小、成像时间和活动浓度的减小与两项指标的COV增加显著相关(P < 0.001)。在68Ga的高T/B下,COV显著降低。在最高T/B时,SUVmax和SUVmean的冠状病毒在18F的典型范围内。对于小目标(8毫米),冠状病毒相对较高,但随着放射性示踪剂的高吸收,冠状病毒会显著减少。
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Small target repeatability of 68Ga and 18F: effects of target concentration and imaging time on SUV measurements in clinically relevant phantoms.

Quantification of tumor uptake using PET imaging is important for the evaluation of therapy response. For 18F FDG PET scans, a change in uptake of 25% is commonly considered significant. For scans using novel radiopharmaceuticals, the threshold of significance is unclear. Factors including imaging time, tumor size, activity concentration, and radiopharmaceutical may affect the repeatablity of uptake metrics. This work evaluates the effect of these parameters on the repeatablity of maximum SUV (SUVmax) and mean SUV (SUVmean) in phantoms using 18F and 68Ga. An Esser PET phantom (Data Spectrum, Durham NC) was scanned on a Biograph Horizon PET/CT scanner (Siemens Medical Solutions, Malvern PA) using 18F and 68Ga. Data were acquired for 5 minutes with reconstructions between 0.5-5 minutes. The background activity mimicked clinical scans with target-to-background (T/B) ratios from 1.7-19.8. The SUVmax and SUVmean were measured for 5 slices. The mean, standard deviation, and coefficient of variation (COV) were calculated. The effects of radionuclide, imaging time, activity concentration, and target size on COV were evaluated using multivariate gamma regressions. COV for 68Ga was 40% higher and 54% higher on average than for 18F for SUVmax and SUVmean, respectively. Decreased lesion size, imaging time, and activity concentration were significantly associated with increased COV for both metrics (P < 0.001). COV was substantially reduced at high T/B for 68Ga. At the highest T/B the COV for SUVmax and SUVmean was within the typical range seen for 18F. COV is relatively high for small targets (8 mm) but is dramatically reduced with high radiotracer uptake.

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来源期刊
American journal of nuclear medicine and molecular imaging
American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
4.00%
发文量
4
期刊介绍: The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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