近场静电纺丝聚己内酯微纤维模拟微动脉-毛细血管-小静脉结构。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2021-09-01 Epub Date: 2021-09-22 DOI:10.1007/s40204-021-00165-4
Imtiaz Qavi, George Z Tan
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引用次数: 2

摘要

为组织工程创建三维(3D)细胞结合结构的能力已经取得了巨大进展。限制组织工程临床应用的主要挑战之一是在3D构建中无法形成足够的毛细血管。缺乏提供营养和氧气的功能性毛细血管网络导致细胞生存能力差。采用近场静电纺丝(ES)技术制备了一种模拟毛细血管形态的支状超细纤维结构。聚己内酯溶液被电纺丝到一个倾斜的收集器上,导致纤维的形态和几何变化。在适当控制溶液粘度和静电纺丝电压的情况下,一根光纤被分散到一个分支光纤网络中,然后在集热器上汇聚回一根光纤。所获得的纤维两端直径小于100微米,具有小于10微米的卷曲和分枝纤维,模拟了微动脉-毛细血管-小静脉结构。在近场能谱中这种结构的形成强烈依赖于溶液粘度。低粘度溶液形成珠状和不连续的线条,因此不能用于实现所需的结构。聚氯乙烯纤维的分支是由于电流体动力学的不稳定性而产生的。从直的大纤维到较小的卷曲/分枝纤维的过渡不是瞬间的,并且在1.5厘米的水平区域上延伸。目前的工作表明,采用具有电位的山谷型集电极静电纺丝茎-枝-茎纤维结构在组织工程应用中的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Near-field electrospinning polycaprolactone microfibers to mimic arteriole-capillary-venule structure.

The ability to create three-dimensional (3D) cell-incorporated constructs for tissue engineering has progressed tremendously. One of the major challenges that limit the clinical applications of tissue engineering is the inability to form sufficient vascularization of capillary vessels in the 3D constructs. The lack of a functional capillary network for supplying nutrients and oxygen leads to poor cell viability. This paper presents the near-field electrospinning (ES) technique to fabricate a branched microfiber structure that mimics the morphology of capillaries. Polycaprolactone solution was electrospun onto a sloped collector that resulted in morphological and geometric variation of the fibers. With proper control over the solution viscosity and the electrospinning voltage, a single fiber was scattered into a branched fiber network and then converged back to a single fiber on the collector. The obtained fibers have a diameter of less than 100 microns at the two ends with coiled and branched fibers of less than 10 microns that mimics the arteriole-capillary-venule structure. The formation of such a structure in the near-field ES strongly depends on the solution viscosity. Low viscosity solutions form beads and discontinuous lines thus cannot be used to achieve the desired structure. The branching of PCL fiber occurs due to an electrohydrodynamic instability. The transition from the straight large fiber to smaller coiled/branched fibers is not instantaneous and stretches over a horizontal region of 1.5 cm. The current work shows the feasibility of electrospinning the stem-branch-stem fibrous structure by adopting a valley-shaped collector with potentials for tissue engineering applications.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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