香港老年妇女骨质疏松症的流行情况

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Osteoporosis and Sarcopenia Pub Date : 2021-09-01 DOI:10.1016/j.afos.2021.09.001
Sue Seen-Tsing Lo
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引用次数: 5

摘要

目的了解65岁及以上女性骨质疏松症的患病率及筛查后需要治疗的比例;他们的治疗接受和延续。方法观察性研究于2017年5月至2020年4月进行。参与者通过双能x线吸收仪进行临床评估和腰椎、全髋关节和股骨颈的骨密度测量。根据骨折风险评估工具®(骨折风险评估工具®),任何部位骨质疏松或骨质减少且10年主要骨折风险≥20%或髋部骨折风险≥3%的患者给予药物治疗。结果1800名受试者中,15.9%为正常,33.2%为低危性骨质减少,27.2%为高危性骨质减少,23.7%为骨质疏松。她们的平均年龄为69.4岁,6.3%在绝经后发生低能性骨折。经逐步logistic回归分析,只有绝经后低能量骨折和低体重指数(BMI)与骨质疏松症有显著相关性。需要治疗的患者年龄较大,45岁或更早绝经,父母有髋部骨折,绝经后有低能性骨折,BMI较低。916名妇女接受了药物治疗,但67.6%的妇女因担心副作用、与现有药物相互作用以及不愿服用更多药物而拒绝。骨质疏松患者的治疗接受度明显较高。骨质疏松患者在第6个月和第12个月的治疗延续率也显著较高。结论老年女性骨质疏松症筛查发现有相当比例的患者需要治疗。鼓励他们开始用药,特别是高风险的骨质减少患者,仍然是一个挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Prevalence of osteoporosis in elderly women in Hong Kong

Objectives

To determine the prevalence of osteoporosis and the proportion who needed treatment after screening women aged 65 years or older; their treatment acceptance and continuation.

Methods

This is an observational study conducted between May 2017 and April 2020.

Participants underwent clinical assessment and bone mineral density measurement of lumbar spine, total hip, and femoral neck by dual energy X-ray absorptiometry. Those with osteoporosis at any site or osteopenia with 10-year major fracture risk ≥ 20% or hip fracture risk ≥ 3% by Fracture Risk Assessment Tool® were offered drug treatment.

Results

Among 1800 participants, 15.9% were normal, 33.2% were low-risk osteopenic, 27.2% were high-risk osteopenic, and 23.7% were osteoporotic. Their mean age was 69.4 years and 6.3% had low-energy fractures after menopause. After stepwise logistic regression analysis, only prior low-energy fractures after menopause and low body mass index (BMI) remained significantly correlated with osteoporosis. Those who needed treatment were significantly older, menopaused at age 45 years or earlier, had a parent with hip fracture, had low-energy fractures after menopause, and low BMI. Drug was offered to 916 women but 67.6% refused because they worried about side effects, interaction with existing drugs, and were reluctant to take more drugs. Treatment acceptance was significantly higher among osteoporotic patients. Treatment continuation at 6th and 12th months was also significantly higher in osteoporotic patients.

Conclusions

Osteoporosis screening in elderly women identified a significant proportion who needed treatment. Encouraging them to initiate drug, especially high-risk osteopenic patients, remained a challenge.

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来源期刊
Osteoporosis and Sarcopenia
Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology
自引率
5.00%
发文量
23
审稿时长
66 days
期刊最新文献
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