ocrelizumab治疗阿拉伯人群多发性硬化症的实际经验。

IF 2.4 Journal of Drug Assessment Pub Date : 2021-10-19 eCollection Date: 2021-01-01 DOI:10.1080/21556660.2021.1989193
Beatriz Garcia-Cañibano, Sami Ouanes, Gowrii Saswathy Ganesan, Wajiha Yousuf, Basel Humos, Tehniyat Baig, Faiza Ibrahim, Rajvir Singh, Dirk Deleu
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引用次数: 3

摘要

目的:关键临床试验显示ocrelizumab在治疗多发性硬化症(MS)中具有良好的临床疗效,同时具有良好的安全性。然而,ocrelizumab在日常临床实践中的实际数据仍然很少。本研究的目的是在现实世界的临床环境中评估ocrelizumab治疗阿拉伯人群多发性硬化症的初步安全性和有效性。方法:在卡塔尔的这项回顾性单中心观察性研究中,我们回顾了2017年10月至2020年12月期间接受至少一次ocrelizumab (Q-OCRE)输注的所有复发-缓解型MS (RRMS)和活动性继发性进展型MS (aSPMS)患者的医疗记录,并分析了临床和MRI数据。结果:共纳入60例MS患者(57例为RRMS, 3例为SPMS)。中位随访期为19个月(范围1-32)。切换到ocrelizumab的最常见原因是疾病活动性增加,并且四分之三的患者先前使用过疾病改善药物(DMD)。73%的队列在第1年没有达到疾病活动(NEDA)状态的证据。有轻度输液相关反应(IRR)和感染的报告(主要是上呼吸道感染,其次是尿路感染),在随访应用中百分比下降。没有观察到严重的副作用。结论:我们的实际经验证实了ocrelizumab在阿拉伯人群中的良好疗效、耐受性和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Real-world experience of ocrelizumab in multiple sclerosis in an Arab population.

Objective: Pivotal clinical trials revealed good clinical efficiency of ocrelizumab while having a good safety profile in the management of multiple sclerosis (MS). However, real-world data of ocrelizumab in daily clinical practice remain scarce. The aim of this study was to evaluate the preliminary safety profile and effectiveness of ocrelizumab treatment for MS in an Arab population in a real-world clinical setting.

Methods: In this retrospective single-center observational study in Qatar, we reviewed the medical records and analyzed the clinical and MRI data of all patients with relapsing-remitting MS (RRMS) and active secondary progressive MS (aSPMS)-between October 2017 through December 2020-who had received at least one infusion of ocrelizumab (Q-OCRE).

Results: A total of 60 MS patients were included (57 with RRMS, three SPMS). The Median follow-up period was 19 months (range, 1-32). The most common reason for switching to ocrelizumab was increased disease activity and three-quarters of the patients were on a previous disease-modifying drug (DMD). No evidence of disease activity (NEDA) status at year 1 was achieved in 73% of the cohort. Mild infusion-related reactions (IRR) and infections were reported (mainly upper respiratory tract infections followed by urinary tract infection) with a declining percentage over the follow-up applications. No severe side effects were observed.

Conclusion: Our real-world experience confirms good efficacy, tolerability, and safety of ocrelizumab in our Arab population.

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来源期刊
Journal of Drug Assessment
Journal of Drug Assessment PHARMACOLOGY & PHARMACY-
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