脐带血干细胞在移植和再生医学中的临床实践-即将到来的时代的巨大希望。

Q3 Biochemistry, Genetics and Molecular Biology Recent patents on biotechnology Pub Date : 2022-01-01 DOI:10.2174/1872208315666211026103227
Suman Kumar Ray, Sukhes Mukherjee
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引用次数: 4

摘要

脐带血通常在分娩后作为不需要的材料处理掉;然而,今天,它被视为一种再生药物,以创造器官组织。从脐带收集的脐带血由间充质干细胞、造血干细胞和多能非造血干细胞组成,这些干细胞具有许多治疗作用,因为这些干细胞用于治疗恶性肿瘤、血液疾病、先天性代谢问题和免疫缺陷。目前,人类脐带血的许多临床应用都与干细胞有关,干细胞治疗也开始了新的研究。这些细胞对干细胞治疗大有裨益;然而,具有特点的是,脐带血保存的前景正在获得动力。目前的研究表明,利用脐带血干细胞可以治疗或缓解包括癌症在内的约80种疾病,每年在世界各地都有效地进行了许多移植。然而,就患者选择、细胞制备、剂量和递送过程等因素而言,微创操作干细胞治疗的治疗程序可以申请专利。同样值得思考的是,这项专利将如何影响脐带血银行。同时,脐带血细胞的使用存在争议,成人来源的细胞可能不那么成功,因此许多临床医生已经开始使用从脐带血中获得的干细胞。这篇综述集中体现了对脐带血细胞研究和脐带血库的看法的变化,理由是脐带血细胞在低温保存或再生医学移植的处理方法上不需要太多。
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Clinical Practice of Umbilical Cord Blood Stem Cells in Transplantation and Regenerative Medicine - Prodigious Promise for Imminent Times.

The umbilical cord blood is usually disposed of as an unwanted material after parturition; however, today, it is viewed as a regenerative medication so as to create the organ tissues. This cord blood gathered from the umbilical cord is made up of mesenchymal stem cells, hematopoietic stem cells, and multipotent non-hematopoietic stem cells having many therapeutic effects as these stem cells are utilized to treat malignancies, hematological ailments, inborn metabolic problem, and immune deficiencies. Presently, numerous clinical applications for human umbilical cord blood inferred stem cells, as stem cell treatment initiate new research. These cells are showing such a boon to stem cell treatment; it is nevertheless characteristic that the prospect of conservation of umbilical cord blood is gaining impetus. Current research works have demonstrated that about 80 diseases, including cancer, can be treated or relieved utilizing umbilical cord blood stem cells, and every year, many transplants have been effectively done around the world. However, in terms of factors, including patient selection, cell preparation, dosing, and delivery process, the treatment procedure for therapy with minimally manipulated stem cells can be patented. It is also worth thinking about how this patent could affect cord blood banks. Meanwhile, the utilization of cord blood cells is controversial and adult-derived cells may not be as successful, so numerous clinicians have begun working with stem cells that are acquired from umbilical cord blood. This review epitomizes a change in outlook from what has been completed with umbilical cord blood cell research and cord blood banking on the grounds that cord blood cells do not require much in the method of handling for cryopreservation or for transplantation in regenerative medicine.

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来源期刊
Recent patents on biotechnology
Recent patents on biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.90
自引率
0.00%
发文量
51
期刊介绍: Recent Patents on Biotechnology publishes review articles by experts on recent patents on biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.
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