Background: Parthenium hysterophorous and Lantana camara are notable for their significant phytochemical and antimicrobial properties. Advancements in phytochemical research have led to the development of novel formulations and products derived from P. hysterophorus and L. camara. For instance, patent extracts from these plants have been utilized in the formulation of pharmaceutical drugs, herbal supplements, cosmeceuticals, and agricultural products. P. hysterophorous, commonly known as Santa Maria feverfew or Congress grass, contains various bioactive compounds like terpenoids, flavonoids, phenolics, and alkaloids.These compounds are the key to its medicinal properties, particularly its antimicrobial activity. On the other hand, L. camara, often referred to as wild sage, is rich in phytochemicals such as terpenoids, flavonoids, and alkaloid glycosides.
Methods: P. hysterophorous and L. camara plants selected and checking their antimicrobial activity by agar well diffusion method.
Results: In our study, we found that the leaf extract of P. hysterophorous exhibited the most potent antibacterial activity against E. coli. P. hysterophorous exhibited the most potent antifungal activity against A. niger and T. viride, with a diameter of inhibition zone measuring 12 mm, followed by A. flavus and A. parasiticus. In case of L. camara, the inhibitory zone ranging from 14 to 18 mm was detected against S. abony, P. aeruginosa, E. coli, and K. pneumonia. The leaf extract of the maximum zone of inhibition in case of L. camara was shown by A. flavus (12mm).
Conclusion: The present study suggests that these two weeds could be useful in the development of bactericides and fungicides.
背景:石蒜(Parthenium hysterophorous)和香茶菜(Lantana camara)具有显著的植物化学和抗菌特性。随着植物化学研究的不断进步,人们开发出了从紫花地丁(P. hysterophorus)和香蒲(L. camara)中提取的新型配方和产品。例如,这些植物的专利提取物已被用于配制药物、草药补充剂、药用化妆品和农产品。P. hysterophorous,俗称圣玛丽亚发热草或国会草,含有多种生物活性化合物,如萜类、黄酮类、酚类和生物碱。另一方面,常被称为野生鼠尾草的 L. camara 含有丰富的植物化学物质,如萜类、黄酮类和生物碱苷类:方法:选择 P. hysterophorous 和 L. camara 植物,用琼脂井扩散法检测其抗菌活性:结果:在研究中,我们发现紫菀的叶提取物对大肠杆菌具有最强的抗菌活性。紫檀叶提取物对黑曲霉和白曲霉的抗真菌活性最强,抑制区直径达 12 毫米,其次是黄曲霉和寄生菌。L. camara 对 S. abony、P. aeruginosa、E. coli 和 K. pneumonia 的抑制区为 14 至 18 毫米。结论:本研究表明,这两种杂草可用于开发杀菌剂和杀真菌剂。
{"title":"Phytochemical Analysis and Antimicrobial Potential of Parthenium hysterophorous and Lantana camara.","authors":"Aliya Firdaus, Syed Khalida Izhar, Shazia Qamar, Arshi Siddiqui, Uzma Afaq","doi":"10.2174/0118722083316748240821151703","DOIUrl":"https://doi.org/10.2174/0118722083316748240821151703","url":null,"abstract":"<p><strong>Background: </strong>Parthenium hysterophorous and Lantana camara are notable for their significant phytochemical and antimicrobial properties. Advancements in phytochemical research have led to the development of novel formulations and products derived from P. hysterophorus and L. camara. For instance, patent extracts from these plants have been utilized in the formulation of pharmaceutical drugs, herbal supplements, cosmeceuticals, and agricultural products. P. hysterophorous, commonly known as Santa Maria feverfew or Congress grass, contains various bioactive compounds like terpenoids, flavonoids, phenolics, and alkaloids.These compounds are the key to its medicinal properties, particularly its antimicrobial activity. On the other hand, L. camara, often referred to as wild sage, is rich in phytochemicals such as terpenoids, flavonoids, and alkaloid glycosides.</p><p><strong>Methods: </strong>P. hysterophorous and L. camara plants selected and checking their antimicrobial activity by agar well diffusion method.</p><p><strong>Results: </strong>In our study, we found that the leaf extract of P. hysterophorous exhibited the most potent antibacterial activity against E. coli. P. hysterophorous exhibited the most potent antifungal activity against A. niger and T. viride, with a diameter of inhibition zone measuring 12 mm, followed by A. flavus and A. parasiticus. In case of L. camara, the inhibitory zone ranging from 14 to 18 mm was detected against S. abony, P. aeruginosa, E. coli, and K. pneumonia. The leaf extract of the maximum zone of inhibition in case of L. camara was shown by A. flavus (12mm).</p><p><strong>Conclusion: </strong>The present study suggests that these two weeds could be useful in the development of bactericides and fungicides.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.2174/0118722083314714240820115610
Giselda Dos Santos Barros, Paula Dos Passos Menezes, Simone de Cássia Silva, Gabriel Francisco da Silva
Background: Diabetic peripheral neuropathy (DPN) is a complication of diabetes that occurs in 40 - 60 million individuals worldwide and is associated with other chronic diseases. However, there are no review studies that present the state-of- the- art and technologies developed to circumvent this important health problem.
Material and methods: This review was conducted based on scientific papers and patents. The papers were retrieved from Lilacs, PubMed, and Web of Science databases, and the patents from INPI, ESPACENET, WIPO, and GOOGLE PATENTS. Thus, a sample consisting of 14 scientific articles and 667 patents was analyzed.
Results: From the analysis of the data, we drew an overview of the development of biomedical technologies for DPN and detected the pioneering spirit of China, the USA, and Japan in the area, with a focus on the treatment of DPN. Based on this, we carried out a SWOT analysis to help direct future efforts in the area, which should focus primarily on developing technologies for prevention, early diagnosis, and, above all, cure of the disease to reduce the important impact of this disease in various sectors of society.
Conclusion: This study finds a concentration of diabetic peripheral neuropathy products, especially therapeutic drugs, in high-income countries. It highlights the need for global collaboration and strategic focus on therapeutic adherence and preventive strategies to effectively manage DPN.
背景:糖尿病周围神经病变(DPN)是糖尿病的一种并发症,全世界有 4,000-6,000 万糖尿病患者,并与其他慢性疾病相关。然而,目前还没有综述性研究介绍最新技术和为解决这一重要健康问题而开发的技术:本综述以科学论文和专利为基础。论文来自 Lilacs、PubMed 和 Web of Science 数据库,专利来自 INPI、ESPACENET、WIPO 和 GOOGLE PATENTS。因此,我们分析了由 14 篇科学论文和 667 项专利组成的样本:结果:通过对数据的分析,我们得出了针对 DPN 的生物医学技术的发展概况,并发现了中国、美国和日本在该领域的开拓精神,重点是 DPN 的治疗。在此基础上,我们进行了 SWOT 分析,以帮助指导该领域未来的工作,其主要重点应放在开发预防、早期诊断,尤其是治愈该疾病的技术上,以减少该疾病对社会各部门的重要影响:本研究发现,糖尿病周围神经病变产品,尤其是治疗药物,主要集中在高收入国家。它强调了全球合作的必要性,以及将战略重点放在坚持治疗和预防策略上以有效控制糖尿病周围神经病变的必要性。
{"title":"The Landscape of Products for Diabetic Peripheral Neuropathy: A Scientific and Patent Systematic Review.","authors":"Giselda Dos Santos Barros, Paula Dos Passos Menezes, Simone de Cássia Silva, Gabriel Francisco da Silva","doi":"10.2174/0118722083314714240820115610","DOIUrl":"https://doi.org/10.2174/0118722083314714240820115610","url":null,"abstract":"<p><strong>Background: </strong>Diabetic peripheral neuropathy (DPN) is a complication of diabetes that occurs in 40 - 60 million individuals worldwide and is associated with other chronic diseases. However, there are no review studies that present the state-of- the- art and technologies developed to circumvent this important health problem.</p><p><strong>Material and methods: </strong>This review was conducted based on scientific papers and patents. The papers were retrieved from Lilacs, PubMed, and Web of Science databases, and the patents from INPI, ESPACENET, WIPO, and GOOGLE PATENTS. Thus, a sample consisting of 14 scientific articles and 667 patents was analyzed.</p><p><strong>Results: </strong>From the analysis of the data, we drew an overview of the development of biomedical technologies for DPN and detected the pioneering spirit of China, the USA, and Japan in the area, with a focus on the treatment of DPN. Based on this, we carried out a SWOT analysis to help direct future efforts in the area, which should focus primarily on developing technologies for prevention, early diagnosis, and, above all, cure of the disease to reduce the important impact of this disease in various sectors of society.</p><p><strong>Conclusion: </strong>This study finds a concentration of diabetic peripheral neuropathy products, especially therapeutic drugs, in high-income countries. It highlights the need for global collaboration and strategic focus on therapeutic adherence and preventive strategies to effectively manage DPN.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.2174/0118722083312186240822051057
Saranjeet Kaur, Akash Deb
Background: In nature, orchid plants are obligate myco-heterotrophs, and rely on mycorrhizal nutrient resources to grow and sustain in the wild, until they become physiologically active photosynthetic plants. Their seeds lack nutrient reserves and receive the necessary carbon from symbiotic fungi during germination. A mycorrhizal fungus provides nutrients, especially sugars, as well as water to the corresponding host plant. The range and distribution of orchid mycorrhizal fungi influence the survivability of orchid populations in their natural habitats. Mycorrhizae form symbiotic connections with the parenchymatous tissues of the roots of orchid plants.
Objective: The objective of this study was to examine the presence of mycorrhiza in the roots of Aerides multiflora during the vegetative phase Methods: Fresh roots were hand-sectioned, and thin sections were observed under the microscope to locate the presence of mycorrhiza. Simultaneously, to observe the expansion of mycorrhiza in the cortical region.
Results: During the vegetative phase of plant growth, a peloton-like structure forms within the cortical region of the orchid roots. Mycorrhizae was observed to be distributed throughout the cortical layer of the root.
Conclusion: This communication reviews the role of mycorrhiza in orchid plants.
{"title":"The Role of Mycorrhizal Fungi in Orchids Mycobiont and Orchids.","authors":"Saranjeet Kaur, Akash Deb","doi":"10.2174/0118722083312186240822051057","DOIUrl":"https://doi.org/10.2174/0118722083312186240822051057","url":null,"abstract":"<p><strong>Background: </strong>In nature, orchid plants are obligate myco-heterotrophs, and rely on mycorrhizal nutrient resources to grow and sustain in the wild, until they become physiologically active photosynthetic plants. Their seeds lack nutrient reserves and receive the necessary carbon from symbiotic fungi during germination. A mycorrhizal fungus provides nutrients, especially sugars, as well as water to the corresponding host plant. The range and distribution of orchid mycorrhizal fungi influence the survivability of orchid populations in their natural habitats. Mycorrhizae form symbiotic connections with the parenchymatous tissues of the roots of orchid plants.</p><p><strong>Objective: </strong>The objective of this study was to examine the presence of mycorrhiza in the roots of Aerides multiflora during the vegetative phase Methods: Fresh roots were hand-sectioned, and thin sections were observed under the microscope to locate the presence of mycorrhiza. Simultaneously, to observe the expansion of mycorrhiza in the cortical region.</p><p><strong>Results: </strong>During the vegetative phase of plant growth, a peloton-like structure forms within the cortical region of the orchid roots. Mycorrhizae was observed to be distributed throughout the cortical layer of the root.</p><p><strong>Conclusion: </strong>This communication reviews the role of mycorrhiza in orchid plants.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-21DOI: 10.2174/0118722083313758240813102715
Arshi Siddiqui, Shaizee, Danish Khan
Introduction: This study aimed to focus on the identification, rearing, and exploration of developmental variants of the predatory ladybird, Coccinella septempunctata L., renowned for its efficacy as a biological control agent and its predation on agricultural pests. However, comprehensive knowledge concerning the occurrence and characteristics of developmental variants in this species remains limited.
Method: In this study, through meticulous monitoring and exploration, we identified developmental variants exhibiting distinct sexual attributes, as well as survival rates.
Result: The research outcomes enhance our understanding of the developmental variations within an egg batch of C. septempunctata.
Conclusion: Moreover, the findings hold practical implications for the implementation of biological control strategies in agriculture, as specific variants may possess unique characteristics that enhance their effectiveness as natural enemies against pests.
{"title":"Exploration of Developmental Variants of Predatory Ladybird, Coccinella septumpunctata L. (Coleoptera: Coccinellidae) on an Artificial Diet.","authors":"Arshi Siddiqui, Shaizee, Danish Khan","doi":"10.2174/0118722083313758240813102715","DOIUrl":"https://doi.org/10.2174/0118722083313758240813102715","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to focus on the identification, rearing, and exploration of developmental variants of the predatory ladybird, Coccinella septempunctata L., renowned for its efficacy as a biological control agent and its predation on agricultural pests. However, comprehensive knowledge concerning the occurrence and characteristics of developmental variants in this species remains limited.</p><p><strong>Method: </strong>In this study, through meticulous monitoring and exploration, we identified developmental variants exhibiting distinct sexual attributes, as well as survival rates.</p><p><strong>Result: </strong>The research outcomes enhance our understanding of the developmental variations within an egg batch of C. septempunctata.</p><p><strong>Conclusion: </strong>Moreover, the findings hold practical implications for the implementation of biological control strategies in agriculture, as specific variants may possess unique characteristics that enhance their effectiveness as natural enemies against pests.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.2174/0118722083301761240628083511
Mushfa Khatoon, Amita Dubey, Janhvi Km Verma
Since ancient times, plants have been used as a remedy for numerous diseases. The pharmacological properties of plants are due to the presence of secondary metabolites like terpenoids, flavonoids, alkaloids, etc. Anthraquinones represent a group of naturally occurring quinones found generously across various plant species. Anthraquinones attract a significant amount of attention due to their reported efficacy in treating a wide range of diseases. Their complex chemical structures, combined with inherent medicinal properties, underscore their potential as agents for therapy. They demonstrate several therapeutic properties such as laxative, antitumor, antimalarial, antibacterial, antifungal, antioxidant, etc. Anthraquinones are found in different forms (derivatives) in plants, and they exhibit various medicinal properties due to their structure and chemical nature. The precursors for the biosynthesis of anthraquinones in higher plants are provided by different pathways such as plastidic hemiterpenoid 2-C-methyl-D-erthriol4-phosphate (MEP), mevalonate (MVA), isochorismate synthase and polyketide. By conducting a thorough analysis of scientific literature, this review provides insights into the intricate interplay between anthraquinone biosynthesis and its broad-ranging contributions to human health.
{"title":"Unveiling Anthraquinones: Diverse Health Benefits of an Essential Secondary Metabolite.","authors":"Mushfa Khatoon, Amita Dubey, Janhvi Km Verma","doi":"10.2174/0118722083301761240628083511","DOIUrl":"https://doi.org/10.2174/0118722083301761240628083511","url":null,"abstract":"<p><p>Since ancient times, plants have been used as a remedy for numerous diseases. The pharmacological properties of plants are due to the presence of secondary metabolites like terpenoids, flavonoids, alkaloids, etc. Anthraquinones represent a group of naturally occurring quinones found generously across various plant species. Anthraquinones attract a significant amount of attention due to their reported efficacy in treating a wide range of diseases. Their complex chemical structures, combined with inherent medicinal properties, underscore their potential as agents for therapy. They demonstrate several therapeutic properties such as laxative, antitumor, antimalarial, antibacterial, antifungal, antioxidant, etc. Anthraquinones are found in different forms (derivatives) in plants, and they exhibit various medicinal properties due to their structure and chemical nature. The precursors for the biosynthesis of anthraquinones in higher plants are provided by different pathways such as plastidic hemiterpenoid 2-C-methyl-D-erthriol4-phosphate (MEP), mevalonate (MVA), isochorismate synthase and polyketide. By conducting a thorough analysis of scientific literature, this review provides insights into the intricate interplay between anthraquinone biosynthesis and its broad-ranging contributions to human health.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.2174/0118722083309510240625085931
Flora Kiaghobadi, Ali Dehshahri, Younes Ghasemi, Mohammad Hossein Morowvat
Aims: Here, we will review different bacterial causes of respiratory tract infections and discuss the available diagnostic methods. Moreover, we will provide some recently published patents and newer techniques, such as respiratory panels and omics approaches, and express the challenges in this path.
Background: Respiratory tract infections (RTIs) include those infections that can lead to the involvement of different respiratory parts, including the sinuses, throat, airways, and lungs. Acute respiratory tract infection is the leading cause of death from infectious illnesses worldwide. According to the World Health Organization, 1.6 to 2.2 million deaths have occurred due to acute respiratory infections in children under five years of age. About 4 million people die annually from respiratory infections, 98% of which are caused by lower respiratory infections.
Results: Depending on the type of pathogen, the severity of the infection can vary from mild to severe and even cause death. The most important pathogens involved in respiratory tract infections include Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The symptoms are often similar, but the treatment can vary greatly. Therefore, correct diagnosis is so important. There are several methods for diagnosing respiratory infections. Traditional tests include the culture of respiratory samples, considered the primary tool for diagnosing respiratory infections in laboratories, and less common standard tests include rapid and antigenic tests. It is essential to think that the culture method is reliable. In the original method of diagnosing respiratory infections, some bacteria were challenging to grow successfully, and many clinical laboratories needed to be equipped for viral cultures. Another issue is the time to get the results, which may take up to 7 days. Rapid and antigenic tests are faster but need to be more accurate.
Conclusion: The clinical laboratories are trying to be equipped with molecular methods for detecting respiratory pathogens and identifying the genetic material of the infectious agent in these new methods as the primary method in their agenda.
{"title":"Emerging Methods in the Identification of Bacterial Respiratory Tract Pathogens.","authors":"Flora Kiaghobadi, Ali Dehshahri, Younes Ghasemi, Mohammad Hossein Morowvat","doi":"10.2174/0118722083309510240625085931","DOIUrl":"https://doi.org/10.2174/0118722083309510240625085931","url":null,"abstract":"<p><strong>Aims: </strong>Here, we will review different bacterial causes of respiratory tract infections and discuss the available diagnostic methods. Moreover, we will provide some recently published patents and newer techniques, such as respiratory panels and omics approaches, and express the challenges in this path.</p><p><strong>Background: </strong>Respiratory tract infections (RTIs) include those infections that can lead to the involvement of different respiratory parts, including the sinuses, throat, airways, and lungs. Acute respiratory tract infection is the leading cause of death from infectious illnesses worldwide. According to the World Health Organization, 1.6 to 2.2 million deaths have occurred due to acute respiratory infections in children under five years of age. About 4 million people die annually from respiratory infections, 98% of which are caused by lower respiratory infections.</p><p><strong>Results: </strong>Depending on the type of pathogen, the severity of the infection can vary from mild to severe and even cause death. The most important pathogens involved in respiratory tract infections include Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The symptoms are often similar, but the treatment can vary greatly. Therefore, correct diagnosis is so important. There are several methods for diagnosing respiratory infections. Traditional tests include the culture of respiratory samples, considered the primary tool for diagnosing respiratory infections in laboratories, and less common standard tests include rapid and antigenic tests. It is essential to think that the culture method is reliable. In the original method of diagnosing respiratory infections, some bacteria were challenging to grow successfully, and many clinical laboratories needed to be equipped for viral cultures. Another issue is the time to get the results, which may take up to 7 days. Rapid and antigenic tests are faster but need to be more accurate.</p><p><strong>Conclusion: </strong>The clinical laboratories are trying to be equipped with molecular methods for detecting respiratory pathogens and identifying the genetic material of the infectious agent in these new methods as the primary method in their agenda.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.2174/0118722083304962240619101244
Ajay Ramdas Nannar
This article offers a thorough analysis of the contemporary application of Achras Sapota Linn, or sapodilla, in conventional medicine. Tropical fruit-bearing Achras Sapota Linn has long been used in many traditional medical systems. The study examines Achras Sapota Linn's phytochemical makeup and pharmacological characteristics with an emphasis on the plant's possible medical uses in the treatment of a range of illnesses. Moreover, it highlights the safety and efficacy characteristics of Achras Sapota Linn and talks about new research and clinical trials that back up its traditional applications. This study also discusses obstacles and potential avenues for further research and application of Achras Sapota Linn in contemporary medicine. All things considered, it emphasizes how important Achras Sapota Linn is to traditional medicine as a therapeutic resource.
本文深入分析了Achras Sapota Linn(又称皂荚)在传统医学中的当代应用。热带水果 Achras Sapota Linn 长期以来一直被用于许多传统医学体系中。本研究探讨了 Achras Sapota Linn 的植物化学成分和药理特性,重点是该植物在治疗一系列疾病方面的可能医疗用途。此外,研究还强调了 Achras Sapota Linn 的安全性和有效性,并介绍了支持其传统应用的新研究和临床试验。本研究还讨论了进一步研究 Achras Sapota Linn 并将其应用于现代医学的障碍和潜在途径。综上所述,本研究强调了 Achras Sapota Linn 作为一种治疗资源对传统医学的重要性。
{"title":"Application of Acharas Sapota Linn in Traditional Medicine.","authors":"Ajay Ramdas Nannar","doi":"10.2174/0118722083304962240619101244","DOIUrl":"https://doi.org/10.2174/0118722083304962240619101244","url":null,"abstract":"<p><p>This article offers a thorough analysis of the contemporary application of Achras Sapota Linn, or sapodilla, in conventional medicine. Tropical fruit-bearing Achras Sapota Linn has long been used in many traditional medical systems. The study examines Achras Sapota Linn's phytochemical makeup and pharmacological characteristics with an emphasis on the plant's possible medical uses in the treatment of a range of illnesses. Moreover, it highlights the safety and efficacy characteristics of Achras Sapota Linn and talks about new research and clinical trials that back up its traditional applications. This study also discusses obstacles and potential avenues for further research and application of Achras Sapota Linn in contemporary medicine. All things considered, it emphasizes how important Achras Sapota Linn is to traditional medicine as a therapeutic resource.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-19DOI: 10.2174/0118722083303431240528041945
Tatiana Duque Martins Ertner de Almeida, Diéricon Sousa Cordeiro
Introduction/objective: During the 1150 days of COVID-19 pandemic there were great efforts to develop efficient treatments for the disease. After this long time, some drugs emerged as treatment for COVID-19. Some of them are new drugs, most of them, known drugs. These developments were triggered by information already available in patent documents. Pharmaceutical companies, therefore, rushed to conduct drugs evaluations and trials in order to deliver to the world a reasonable treatment that could reach the majority of its population. However, it is not immediately clear how companies operated to reach their goals. The ability of open innovation to achieve results assertively and faster than closed innovation strategies is questioned and therefore, it is questioned whether pharmaceutical companies use open innovation to face COVID-19.
Methods: In this work, data available on patent databases were mined to inform about the scientific and technological panorama of selected drugs tested for COVID-19 treatment and to understand the perspectives of such developments during the pandemic.
Results: This study evidenced that most treatments were based on known drugs, that some of the initially promising drugs were abandoned during the pandemic, and that it was able to inform if open innovation and collaborations were explored strategies.
Conclusion: This study evidenced that the developments during COVID-19 were not based on open innovation by revealing a patent race towards the treatment development, but with practically no collaborations or information exchange between companies, universities, and research facilities.
{"title":"Open Innovation or Traditional Patenting Strategies to Efficiently Address Health Emergencies? How Patent Information Was Used Towards Effective Treatments for COVID-19.","authors":"Tatiana Duque Martins Ertner de Almeida, Diéricon Sousa Cordeiro","doi":"10.2174/0118722083303431240528041945","DOIUrl":"https://doi.org/10.2174/0118722083303431240528041945","url":null,"abstract":"<p><strong>Introduction/objective: </strong>During the 1150 days of COVID-19 pandemic there were great efforts to develop efficient treatments for the disease. After this long time, some drugs emerged as treatment for COVID-19. Some of them are new drugs, most of them, known drugs. These developments were triggered by information already available in patent documents. Pharmaceutical companies, therefore, rushed to conduct drugs evaluations and trials in order to deliver to the world a reasonable treatment that could reach the majority of its population. However, it is not immediately clear how companies operated to reach their goals. The ability of open innovation to achieve results assertively and faster than closed innovation strategies is questioned and therefore, it is questioned whether pharmaceutical companies use open innovation to face COVID-19.</p><p><strong>Methods: </strong>In this work, data available on patent databases were mined to inform about the scientific and technological panorama of selected drugs tested for COVID-19 treatment and to understand the perspectives of such developments during the pandemic.</p><p><strong>Results: </strong>This study evidenced that most treatments were based on known drugs, that some of the initially promising drugs were abandoned during the pandemic, and that it was able to inform if open innovation and collaborations were explored strategies.</p><p><strong>Conclusion: </strong>This study evidenced that the developments during COVID-19 were not based on open innovation by revealing a patent race towards the treatment development, but with practically no collaborations or information exchange between companies, universities, and research facilities.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.2174/0118722083300181240429072502
Roohi Roohi, Naushin Bano
Antibiotics are considered "wonder drugs" due to the fact that they are the most extensively utilised medication in the world. They are used to cure a broad spectrum of diseases and lethal infections. A variety of bacteria and fungi produce antibiotics as a result of secondary metabolism; however, their production is dominated by a special class of bacteria, namely Actinobacteria. Actinobacteria are gram-positive bacteria with high G+C content and unparalleled antibiotic-producing ability. They produce numerous polyenes, tetracyclines, β-lactams, macrolides, and peptides. Actinobacteria are ubiquitous in nature and are isolated from various sources, such as marine and terrestrial endophytes of plants and air. They are studied for their relative antibiotic-producing ability along with the mechanism that the antibiotics follow to annihilate the pathogenic agents that include bacteria, fungi, protozoans, helminths, etc. Actinobacteria isolated from endophytes of medicinal plants have amassed significant attention as they interfere with the metabolism of medicinal plants and acquire enormous benefits from it in the form of conspicuous novel antibiotic-producing ability. Actinobacteria is not only an antibiotic but also a rich source of anticancer compounds that are widely used owing to its remarkable tumorigenic potential. Today, amongst Actinobacteria, class Streptomyces subjugates the area of antibiotic production, producing 70% of all known antibiotics. The uniqueness of bioactive Actinobacteria has turned the attention of scientists worldwide in order to explore its potentiality as effective "micronanofactories". This study provides a brief overview of the production of antibiotics from Actinobacteria inhabiting diverse environments and the methods involved in the screening of antibiotics.
{"title":"Actinobacteria: Smart Micro-Factories for The Health Sector.","authors":"Roohi Roohi, Naushin Bano","doi":"10.2174/0118722083300181240429072502","DOIUrl":"https://doi.org/10.2174/0118722083300181240429072502","url":null,"abstract":"<p><p>Antibiotics are considered \"wonder drugs\" due to the fact that they are the most extensively utilised medication in the world. They are used to cure a broad spectrum of diseases and lethal infections. A variety of bacteria and fungi produce antibiotics as a result of secondary metabolism; however, their production is dominated by a special class of bacteria, namely Actinobacteria. Actinobacteria are gram-positive bacteria with high G+C content and unparalleled antibiotic-producing ability. They produce numerous polyenes, tetracyclines, β-lactams, macrolides, and peptides. Actinobacteria are ubiquitous in nature and are isolated from various sources, such as marine and terrestrial endophytes of plants and air. They are studied for their relative antibiotic-producing ability along with the mechanism that the antibiotics follow to annihilate the pathogenic agents that include bacteria, fungi, protozoans, helminths, etc. Actinobacteria isolated from endophytes of medicinal plants have amassed significant attention as they interfere with the metabolism of medicinal plants and acquire enormous benefits from it in the form of conspicuous novel antibiotic-producing ability. Actinobacteria is not only an antibiotic but also a rich source of anticancer compounds that are widely used owing to its remarkable tumorigenic potential. Today, amongst Actinobacteria, class Streptomyces subjugates the area of antibiotic production, producing 70% of all known antibiotics. The uniqueness of bioactive Actinobacteria has turned the attention of scientists worldwide in order to explore its potentiality as effective \"micronanofactories\". This study provides a brief overview of the production of antibiotics from Actinobacteria inhabiting diverse environments and the methods involved in the screening of antibiotics.</p>","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.2174/0118722083301253240417114400
N. Bano, Syed Khalida Izhar, Anamika Gupta, M. Zaheer, Roohi
Nanoparticles bestow beneficial impacts on plants, specifically in increasing photosynthetic capacity and germination rate, pesticide delivery, managing pathogenicity and enhancing nutrient supply. The nanoparticles produced from the medicinal plant extracts are identified as an exceptional applicant in nanomedicine, cosmetics, and agriculture for the treatment of diseases as antimicrobial, antioxidant and anticancer agents, etc. Plant extracts actually have bioactive metabolites that provide therapeutic potential against a variety of diseases. Herein, we review the production of bioactive compounds from leaves, roots, seeds, flowers and stems. We further summarize the different methods for obtaining plant extracts and the green technologies for the synthesis of nanoparticles of plant derived bioactive compounds. Biotechnological aspects of these synthesized nanoparticles are also added here as highlights of this review. Overall, plant derived nanoparticles provide an alternative to conventional approaches for drug delivery as well and present exciting opportunities for future research on novel areas.
{"title":"Prospects of Plant Derived Bioactive Compounds as Nanoparticles for Biotechnological Applications.","authors":"N. Bano, Syed Khalida Izhar, Anamika Gupta, M. Zaheer, Roohi","doi":"10.2174/0118722083301253240417114400","DOIUrl":"https://doi.org/10.2174/0118722083301253240417114400","url":null,"abstract":"Nanoparticles bestow beneficial impacts on plants, specifically in increasing photosynthetic capacity and germination rate, pesticide delivery, managing pathogenicity and enhancing nutrient supply. The nanoparticles produced from the medicinal plant extracts are identified as an exceptional applicant in nanomedicine, cosmetics, and agriculture for the treatment of diseases as antimicrobial, antioxidant and anticancer agents, etc. Plant extracts actually have bioactive metabolites that provide therapeutic potential against a variety of diseases. Herein, we review the production of bioactive compounds from leaves, roots, seeds, flowers and stems. We further summarize the different methods for obtaining plant extracts and the green technologies for the synthesis of nanoparticles of plant derived bioactive compounds. Biotechnological aspects of these synthesized nanoparticles are also added here as highlights of this review. Overall, plant derived nanoparticles provide an alternative to conventional approaches for drug delivery as well and present exciting opportunities for future research on novel areas.","PeriodicalId":21064,"journal":{"name":"Recent patents on biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}