用生物活性复合水凝胶对长碳纤维增强聚醚醚酮进行表面改性,获得有效的成骨效果

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS Materials science & engineering. C, Materials for biological applications Pub Date : 2021-11-01 DOI:10.1016/j.msec.2021.112451
Wenying Dong , Wendi Ma , Shanshan Zhao , Yilong Wang , Jihang Yao , Zhewen Liu , Zheng Chen , Dahui Sun , Zhenhua Jiang , Mei Zhang
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引用次数: 6

摘要

长碳纤维增强聚醚醚酮(LCFRPEEK)在我们之前的工作中使用三维(3D)针刺方法制造,由于其高机械强度和各向同性特性,以及与人类皮质骨相似的弹性模量,被认为是一种潜在的骨科植入物。然而,LCFRPEEK与骨组织的结合较差,限制了其临床应用。因此,我们开发了一种简单的表面改性方法,将甲基丙烯酸明胶/聚丙烯酰胺复合水凝胶涂层(GelMA/PAAM)负载地塞米松(Dex),通过浓硫酸磺化和紫外线(UV)照射接枝的方法,在我们新开发的LCFRPEEK复合材料上进行表面改性。结果表明,GelMA/PAAM/Dex涂层修饰的磺化LCFRPEEK (SCP/GP/Dex)具有亲水性表面,具有长期释放Dex的能力,在SBF中形成更多骨样磷灰石小结。在体外实验中,SCP/GP/Dex在大鼠骨髓间充质干细胞(rBMSCs)应答方面也显示出增强的细胞相容性和成骨分化。体内大鼠颅骨缺损实验证实,SCP/GP/Dex促进骨再生/骨整合,显著改善种植体与骨组织之间的成骨固定。因此,新开发的经GelMA/PAAM/Dex生物活性涂层修饰的LCFRPEEK具有更好的生物相容性和成骨整合能力,为骨科植入物的临床应用奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The surface modification of long carbon fiber reinforced polyether ether ketone with bioactive composite hydrogel for effective osteogenicity

Long carbon fiber reinforced polyether ether ketone (LCFRPEEK) is fabricated using a three-dimensional (3D) needle-punched method in our previous work, which is considered as a potential orthopedic implant due to its high mechanical strength and isotropic properties, as well as having an elastic modulus similar to human cortical bone. However, the LCFRPEEK has inferior integration with bone tissue, limiting its clinical application. Thus, a facile surface modification method, using gelatin methacrylate/polyacrylamide composite hydrogel coating (GelMA/PAAM) loading with dexamethasone (Dex) on our newly-developed LCFRPEEK composite via concentrated sulfuric acid sulfonating and ultraviolet (UV) irradiation grafting methods, has been developed to tackle the problem. The results demonstrate that the GelMA/PAAM/Dex coating modified sulfonated LCFRPEEK (SCP/GP/Dex) has a hydrophilicity surface, a long-term Dex release capability and forms more bone-like apatite nodules in SBF. The SCP/GP/Dex also displays enhanced cytocompatibility and osteogenic differentiation in terms of rat bone marrow mesenchymal stem cells (rBMSCs) responses in vitro assay. The in vivo rat cranial defect assay confirms that SCP/GP/Dex boosts bone regeneration/osseointegration, which significantly improves osteogenic fixation between the implant and bone tissue. Therefore, the newly-developed LCFRPEEK modified via GelMA/PAAM/Dex bioactive coating exhibits improved biocompatibility and osteogenic integration capability, which has the basis for an orthopedic implant for clinical application.

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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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