果蝇各种组织中的肿瘤模型。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2021-11-01 Epub Date: 2021-03-21 DOI:10.1002/wsbm.1525
Shangyu Gong, Yichi Zhang, Aiguo Tian, Wu-Min Deng
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引用次数: 0

摘要

癌症的发生发展是一个复杂的多阶段过程。过去几十年来,黑腹果蝇这一模式生物在鉴定癌症相关基因和途径以及阐明发育过程中的生长调控机制方面发挥了至关重要的作用。利用果蝇进行的研究对肿瘤发生和发展的分子机制有了新的认识。在这篇综述中,我们介绍了近年来利用果蝇的不同组织(如想象组织、神经组织、肠道、卵巢和造血细胞)建立的各种肿瘤模型。我们将讨论这些模型的潜在基因改变、类癌特征以及相似之处和主要差异。我们还讨论了干细胞分裂和分化紊乱如何导致肿瘤在不同组织中形成,并重点介绍了利用蝇类模型理解肿瘤发生的环境依赖性的新概念。我们进一步讨论了果蝇在探索肿瘤-宿主相互作用方面取得的进展,这种相互作用涉及对肿瘤生长的先天免疫反应和恶病质消瘦表型。本文归类于癌症 > 遗传学/基因组学/表观遗传学 癌症 > 干细胞与发育 癌症 > 分子与细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Tumor models in various Drosophila tissues.

The development of cancer is a complex multistage process. Over the past few decades, the model organism Drosophila melanogaster has been crucial in identifying cancer-related genes and pathways and elucidating mechanisms underlying growth regulation in development. Investigations using Drosophila has yielded new insights into the molecular mechanisms involved in tumor initiation and progression. In this review, we describe various tumor models that have been developed in recent years using different Drosophila tissues, such as the imaginal tissue, the neural tissue, the gut, the ovary, and hematopoietic cells. We discuss underlying genetic alterations, cancer-like characteristics, as well as similarities and key differences among these models. We also discuss how disruptions in stem cell division and differentiation result in tumor formation in diverse tissues, and highlight new concepts developed using the fly model to understand context-dependent tumorigenesis. We further discuss the progress made in Drosophila to explore tumor-host interactions that involve the innate immune response to tumor growth and the cachexia wasting phenotype. This article is categorized under: Cancer > Genetics/Genomics/Epigenetics Cancer > Stem Cells and Development Cancer > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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