寡转移胰腺癌的手术挑战：文献系统回顾。

Q2 Medicine Journal of Buon Pub Date : 2021-09-01

Gregory Christodoulidis, Dimitrios Magouliotis, Athina Samara, Theodoros Floros, Prokopis Andreas Zotos, Maria Tolia, Dimitris Zacharoulis

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引用次数: 0

摘要

目的：我们旨在回顾有关寡转移性胰腺导管腺癌（PDAC）手术治疗的现有文献，以评估不同策略的临床效果和术中参数：根据 PRISMA 指南，在 PubMed 数据库中进行了系统性文献检索。9项研究符合纳入标准，共纳入401名患者：结果：胰腺癌切除术合并同步转移切除术的围手术期死亡率低至0%：目前，与之前的试验相比，术后总生存期和无进展生存期都有所提高。结论：目前，术后总生存率和无进展生存率较之前的试验有所提高，但由于缺乏准确的手术指征，延迟了生存率的提高。有必要进行设计完善的随机对照研究，评估胰腺手术联合转移瘤切除术的临床效果。

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The surgical challenge of oligometastatic pancreatic cancer: A systemic review of the literature.

Purpose: We aim to review the available literature on surgical management of oligometastatic pancreatic ductal adenocarcinoma (PDAC), in order to assess the clinical outcomes and intraoperative parameters of the different strategies.

Methods: A systematic literature search was performed in PubMed database, in accordance with the PRISMA guidelines. Nine studies met the inclusion criteria incorporating 401 patients.

Results: Perioperative mortality was as low as 0%, regarding resection of pancreatic cancer combined with synchronous metastasectomy.

Conclusions: Currently, postoperative overall survival and progression-free survival have increased compared to previous trials. Nevertheless, the lack of precise operative indications delays the enhancement of survival rates. Well-designed, randomized controlled studies, assessing pancreatic surgery combined with metastasectomy, are necessary to further assess their clinical outcomes.

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来源期刊

Journal of Buon 医学-肿瘤学

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： JBUON aims at the rapid diffusion of scientific knowledge in Oncology. Its character is multidisciplinary, therefore all aspects of oncologic activities are welcome including clinical research (medical oncology, radiation oncology, surgical oncology, nursing oncology, psycho-oncology, supportive care), as well as clinically-oriented basic and laboratory research, cancer epidemiology and social and ethical aspects of cancer. Experts of all these disciplines are included in the Editorial Board. With a rapidly increasing body of new discoveries in clinical therapeutics, the molecular mechanisms that contribute to carcinogenesis, advancements in accurate and early diagnosis etc, JBUON offers a free forum for clinicians and basic researchers to make known promptly their achievements around the world. With this aim JBUON accepts a broad spectrum of articles such as editorials, original articles, reviews, special articles, short communications, commentaries, letters to the editor and correspondence among authors and readers. JBUON keeps the characteristics of its former paper print edition and appears as a bimonthly e-published journal with continuous volume, issue and page numbers.