基于纳米材料的抗击新冠肺炎策略的进展。

View (Beijing, China) Pub Date : 2021-08-01 Epub Date: 2021-05-05 DOI:10.1002/VIW.20200180
Chunxi Zeng, Xucheng Hou, Margaret Bohmer, Yizhou Dong
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摘要

严重急性呼吸系统综合征冠状病毒2型由于其高传染性,已在全球感染了1亿多人。经过几十年对纳米材料的研究,研究人员应用了基于纳米材料的策略来抗击2019冠状病毒病(新冠肺炎)的大流行。首先,纳米材料有助于开发简单、快速、低成本的诊断分析方法,以检测严重急性呼吸系统综合征冠状病毒2型和相关生物标志物。其次,纳米材料能够有效地将病毒抗原递送到抗原呈递细胞或作为宿主的佐剂,从而以前所未有的速度开发疫苗。最后,基于纳米材料的治疗可以抑制严重急性呼吸系统综合征冠状病毒2型的复制并减少炎症。总体而言,纳米材料在控制这场新冠肺炎大流行方面发挥了重要作用。在这里,我们简要概述了基于纳米材料的诊断、疫苗和治疗在抗击新冠肺炎中的代表性例子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Advances of nanomaterials-based strategies for fighting against COVID-19.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 100 million people globally due to its high infectivity. After decades of efforts on the studies of nanomaterials, researchers have applied nanomaterials-based strategies to combat the pandemic of the coronavirus disease 2019 (COVID-19). First, nanomaterials facilitate the development of easy, fast, and low-cost diagnostic assays to detect SARS-CoV-2 and related biomarkers. Second, nanomaterials enable the efficient delivery of viral antigens to antigen-presenting cells or serve as adjuvants in the host, leading to vaccine development at an unprecedented pace. Lastly, nanomaterials-based treatments may inhibit SARS-CoV-2 replication and reduce inflammation. Overall, nanomaterials have played important roles in controlling this COVID-19 pandemic. Here, we provide a brief overview of the representative examples of nanomaterials-based diagnostics, vaccines, and therapeutics in the fight against COVID-19.

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