Development of light-degradable poly(urethane-urea) hydrogel films

Biocompatible hydrogels are exciting platforms that have stood out in recent years for their outstanding potential for biomedical applications. For these applications, the ability of the material to respond to an external stimulus can be a relevant addition. This responsiveness allows the material to modify its physical properties in such a way that it can deliver molecules that support the healing process or allow easy removal of the films from the tissue. Among the polymers used to produce these systems, polyurethane (PU) and polyurethane-urea (PUU) are some of the most cited examples. In this work, a new hydrogel-sensitive PUU film is proposed. These films are prepared from polyethylene glycol (PEG) and contain a ROS-responsive telechelic β-aminoacrylate bond. The hydrogel films showed interesting mechanical and thermal properties, good water uptake and low cytotoxicity, which makes them suitable for biomedical applications. More importantly, the hydrogel films exhibited a light-degradable profile through an innovative ROS-mediated cleavage process, as indicated by the loss of mechanical properties.