白桦果纯化的标准操作程序及白桦果苷的生药学和分析性质。

Ayu Pub Date : 2020-04-01 Epub Date: 2021-10-23 DOI:10.4103/ayu.AYU_299_20
Sonam S Bhinde, Arun Kumar Ravi, Biswajyoti J Patgiri, C R Harisha, Vinay J Shukla
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引用次数: 1

摘要

简介:Shodhana(纯化)是去除原药的杂质或毒性,使药物适合治疗目的的过程。Chitraka (Plumbago zeylanica Linn.)是阿育吠陀中众所周知的药物,这种植物的根被用于治疗目的,在用作药物之前需要纯化。目的和目的:由于目前还没有炮制的千里马药材的生药学和分析资料,因此计划通过炮制的千里马药材的生药学和分析资料来制定炮制的千里马药材的鉴别、纯度和强度的标准操作规程。材料和方法:从贾姆纳格尔古吉拉特大学药房采购。用Churnodaka(石灰水)分五批进行纯化。对纯化前后的感官特性、显微特征、pH值、干燥损失、灰分值、水溶性提取物、甲醇可溶性提取物和白丹素进行了高效薄层色谱(HPTLC)定量分析。结果:纯化后赤曲霉平均得率为98.07%。不同纯化工艺对赤子药材的感官特征、生药学特性和理化参数有不同的影响。hplc图谱显示,未纯化的白桦粉中白桦苷含量为0.29%,纯化后白桦粉中白桦苷含量为0.98%。结论:石灰水纯化白桦药材过程中白桦苷含量的增加表明,该操作方法简单、方便,可作为标准操作程序。纯化白桦粉的感官特征、生药学特性、理化参数值和白桦苷的含量可作为今后研究的质量保证。
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Standard operating procedure of Purification of Chitraka (Plumbago zeylanica Linn.) along with pharmacognostical and analytical profiles of Plumbagin.

Introduction: Shodhana (purification) is the process by which one can remove the impurity or toxicity of the raw drug and make the drug suitable for therapeutic purpose. Chitraka (Plumbago zeylanica Linn.) is well known drug in Ayurveda and root of this plant is being used for therapeutic purpose and requires purification before used as a medicine.

Aims and objective: There is no data available for pharmacognostical and analytical profile of processed Chitraka, hence it was planned to develop SOP of processed Chitraka for its identity, purity and strength through pharmacognostical and analytical profile.

Materials and methods: Chitraka roots were procured from Pharmacy, Gujarat Ayurved University, Jamnagar. Purification was done in five batches with Churnodaka (lime water). Organoleptic characters, microscopic features, pH, loss on drying, ash value, water soluble extracts, methanol soluble extracts and plumbagin quantification through high-performance thin layer chromatography (HPTLC) were carried out, before and after the purification.

Results: Average 98.07% yield of Chitraka was obtained after purification. Differences were found in the processed samples of Chitraka in organoleptic features, pharmacognostical characters and physicochemical parameters, which show the impact of purification procedure on Chitraka. In HPTLC profile, plumbagin content was 0.29% in unpurified Chitraka powder, where in it was noted 0.98% after purification.

Conclusion: Increase in plumbagin content through pharmaceutical process of Chitraka purification with lime water indicates that, this operating procedure is simple, convenient and can be considered as standard procedure. The organoleptic features, pharmacognostical characters, values of physicochemical parameters and quantity of plumbagin of purified Chitraka powder may be utilized for quality assurance in future studies.

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