羧甲基壳聚糖锌(CMCS-Zn)/半水合α-硫酸钙(α- csh)复合材料的物理化学和生物学性能

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS Materials science & engineering. C, Materials for biological applications Pub Date : 2021-12-01 DOI:10.1016/j.msec.2021.112496
Jianchun Lin , Daorong Xu , Zhongguo Liu , Yi Jiang , Mingliang Ren , Haibo Xiang , Bin Yu
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引用次数: 6

摘要

为了提高半水合硫酸钙(CSH)的成骨性、抗菌活性和临床应用价值,采用不同质量比制备了羧甲基壳聚糖锌(CMCS-Zn)和α-CSH。CMCS-Zn/α-CSH复合材料的凝固时间和注射性随CMCS-Zn含量的增加而增加。在α-CSH中加入不同量的CMCS-Zn后,通过扫描电镜(SEM)观察到CMCS-Zn呈细小的片层状结构,均匀分布在α-CSH基体中。随着CMCS-Zn含量的增加,表面气孔逐渐增多。将CMCS-Zn与α-CSH混合后,x射线衍射(XRD)和傅里叶变换(FTIR)均未检测到新相。随着CMCS-Zn含量的增加,CMCS-Zn/α-CSH的降解速率降低,且降解过程中pH保持稳定。随着CMCS-Zn含量的增加,Zn2+的释放量增加,Ca2+的释放量减少。CMCS-Zn/α-CSH复合物提取物上调大鼠骨髓干细胞的成骨诱导和迁移能力。CMCS-Zn/α-CSH的抑菌能力以CMCS-Zn含量为函数进行评价。在大鼠骨缺损模型中,5% CMCS-Zn/α-CSH组术后8周显微ct显示骨小梁体积和密度较高。因此,CMCS-Zn/α-CSH被证明是一种可调节,可降解的替代生物材料(具有促进成骨作用),用于骨缺损,并且具有抗菌活性,可以抑制骨感染。
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Physicochemical and biological properties of carboxymethyl chitosan zinc (CMCS-Zn)/α‑calcium sulfate hemihydrate (α-CSH) composites

To improve the osteoinductivity, antibacterial activity, and clinical application of calcium sulfate hemihydrate (CSH), carboxymethyl chitosan zinc (CMCS-Zn) and α-CSH were prepared using different mass ratios. The setting time and injectability of the CMCS-Zn/α-CSH composite were increased with increasing CMCS-Zn content. After adding different amounts of CMCS-Zn to α-CSH, the fine lamellar structure of CMCS-Zn was found by scanning electron microscopy (SEM), which is evenly distributed in the matrix of α-CSH. With the increase of CMCS-Zn, the pores on the surface gradually increased. After mixing CMCS-Zn and α-CSH, no new phase was measured by X-ray diffraction (XRD) and Fourier transform (FTIR) spectroscopy. The degradation rate of CMCS-Zn/α-CSH decreased with increasing CMCS-Zn content, and the pH was stable during the degradation process. The release of Zn2+ increased with increasing CMCS-Zn content, while the release of Ca2+ decreased. Extracts of CMCS-Zn/α-CSH composites up-regulated the osteoinduction and migration of rat bone marrow stem cells. The antibacterial ability of CMCS-Zn/α-CSH was evaluated as a function of CMCS-Zn content. In the rat bone defect model, 5% CMCS-Zn/α-CSH group revealed a higher volume and density of trabeculae by micro-CT 8 weeks after the operation. Therefore, CMCS-Zn/α-CSH was demonstrated to be an adjustable, degradable, substitute biomaterial (with osteogenesis-promoting effects) for use in bone defects, which also has antibacterial activity that can suppress bone infection.

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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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