Diego Pacheco Wermuth , Thaís Casagrande Paim , Isadora Bertaco , Carla Zanatelli , Liliana Ivet Sous Naasani , Mônica Slaviero , David Driemeier , André Carvalho Tavares , Vinicius Martins , Camila Ferreira Escobar , Luis Alberto Loureiro dos Santos , Lirio Schaeffer , Márcia Rosângela Wink
{"title":"金属注射成型纯铁多孔植入物的力学性能、体外和体内生物相容性分析——天然橡胶(巴西橡胶树)的新型环保原料","authors":"Diego Pacheco Wermuth , Thaís Casagrande Paim , Isadora Bertaco , Carla Zanatelli , Liliana Ivet Sous Naasani , Mônica Slaviero , David Driemeier , André Carvalho Tavares , Vinicius Martins , Camila Ferreira Escobar , Luis Alberto Loureiro dos Santos , Lirio Schaeffer , Márcia Rosângela Wink","doi":"10.1016/j.msec.2021.112532","DOIUrl":null,"url":null,"abstract":"<div><p>Metal injection molding (MIM) has become an important manufacturing technology for biodegradable medical devices. As a biodegradable metal, pure iron is a promising biomaterial due to its mechanical properties and biocompatibility. In light of this, we performed the first study that manufactured and evaluated the <em>in vitro</em> and <em>in vivo</em> biocompatibility of samples of iron porous implants produced by MIM with a new eco-friendly feedstock from natural rubber (<em>Hevea brasiliensis</em>), a promisor binder that provides elastic property in the green parts. The iron samples were submitted to tests to determine density, microhardness, hardness, yield strength, and stretching. The biocompatibility of the samples was studied <em>in vitro</em> with adipose-derived mesenchymal stromal cells (ADSCs) and erythrocytes, and <em>in vivo</em> on a preclinical model with Wistar rats, testing the iron samples after subcutaneous implant. Results showed that the manufactured samples have adequate physical, and mechanical characteristics to biomedical devices and they are cytocompatible with ADSCs, hemocompatible and biocompatible with Wistars rats. Therefore, pure iron produced by MIM can be considered a promising material for biomedical applications.</p></div>","PeriodicalId":18212,"journal":{"name":"Materials science & engineering. C, Materials for biological applications","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S092849312100672X/pdfft?md5=10dbb5eeff57c3eebfc27ae57978b715&pid=1-s2.0-S092849312100672X-main.pdf","citationCount":"9","resultStr":"{\"title\":\"Mechanical properties, in vitro and in vivo biocompatibility analysis of pure iron porous implant produced by metal injection molding: A new eco-friendly feedstock from natural rubber (Hevea brasiliensis)\",\"authors\":\"Diego Pacheco Wermuth , Thaís Casagrande Paim , Isadora Bertaco , Carla Zanatelli , Liliana Ivet Sous Naasani , Mônica Slaviero , David Driemeier , André Carvalho Tavares , Vinicius Martins , Camila Ferreira Escobar , Luis Alberto Loureiro dos Santos , Lirio Schaeffer , Márcia Rosângela Wink\",\"doi\":\"10.1016/j.msec.2021.112532\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Metal injection molding (MIM) has become an important manufacturing technology for biodegradable medical devices. As a biodegradable metal, pure iron is a promising biomaterial due to its mechanical properties and biocompatibility. In light of this, we performed the first study that manufactured and evaluated the <em>in vitro</em> and <em>in vivo</em> biocompatibility of samples of iron porous implants produced by MIM with a new eco-friendly feedstock from natural rubber (<em>Hevea brasiliensis</em>), a promisor binder that provides elastic property in the green parts. The iron samples were submitted to tests to determine density, microhardness, hardness, yield strength, and stretching. The biocompatibility of the samples was studied <em>in vitro</em> with adipose-derived mesenchymal stromal cells (ADSCs) and erythrocytes, and <em>in vivo</em> on a preclinical model with Wistar rats, testing the iron samples after subcutaneous implant. 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Mechanical properties, in vitro and in vivo biocompatibility analysis of pure iron porous implant produced by metal injection molding: A new eco-friendly feedstock from natural rubber (Hevea brasiliensis)
Metal injection molding (MIM) has become an important manufacturing technology for biodegradable medical devices. As a biodegradable metal, pure iron is a promising biomaterial due to its mechanical properties and biocompatibility. In light of this, we performed the first study that manufactured and evaluated the in vitro and in vivo biocompatibility of samples of iron porous implants produced by MIM with a new eco-friendly feedstock from natural rubber (Hevea brasiliensis), a promisor binder that provides elastic property in the green parts. The iron samples were submitted to tests to determine density, microhardness, hardness, yield strength, and stretching. The biocompatibility of the samples was studied in vitro with adipose-derived mesenchymal stromal cells (ADSCs) and erythrocytes, and in vivo on a preclinical model with Wistar rats, testing the iron samples after subcutaneous implant. Results showed that the manufactured samples have adequate physical, and mechanical characteristics to biomedical devices and they are cytocompatible with ADSCs, hemocompatible and biocompatible with Wistars rats. Therefore, pure iron produced by MIM can be considered a promising material for biomedical applications.
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