{"title":"以广泛中和抗体为基础的应对流感策略","authors":"Xiaoyu Sun , Zhiyang Ling , Zhuo Yang, Bing Sun","doi":"10.1016/j.coviro.2022.101207","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Influenza viruses cause occasional pandemics and annual epidemics, thus persist as a threat to human society. The high variability of viral envelope proteins resulting from </span>antigenic shift and </span>antigenic drift<span><span><span> allows influenza viruses to escape human herd immunity<span><span>. During the past decade, along with the breakthroughs of human monoclonal antibody<span><span> technologies, many broad reactive monoclonal antibodies (mAbs) that neutralize diverse influenza subtypes have been isolated and characterized. The achievements in this field have provided potential candidates of anti-influenza therapeutics and shed light on the design of universal </span>influenza vaccines. Here, we review the broad </span></span>neutralizing antibodies (bnAbs) targeting the </span></span>virus </span>surface proteins, summarize their epitopes, broad spectrum and immunological mechanisms of action and discuss the design of universal influenza vaccines inspired by bnAbs.</span></p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Broad neutralizing antibody-based strategies to tackle influenza\",\"authors\":\"Xiaoyu Sun , Zhiyang Ling , Zhuo Yang, Bing Sun\",\"doi\":\"10.1016/j.coviro.2022.101207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Influenza viruses cause occasional pandemics and annual epidemics, thus persist as a threat to human society. The high variability of viral envelope proteins resulting from </span>antigenic shift and </span>antigenic drift<span><span><span> allows influenza viruses to escape human herd immunity<span><span>. During the past decade, along with the breakthroughs of human monoclonal antibody<span><span> technologies, many broad reactive monoclonal antibodies (mAbs) that neutralize diverse influenza subtypes have been isolated and characterized. The achievements in this field have provided potential candidates of anti-influenza therapeutics and shed light on the design of universal </span>influenza vaccines. Here, we review the broad </span></span>neutralizing antibodies (bnAbs) targeting the </span></span>virus </span>surface proteins, summarize their epitopes, broad spectrum and immunological mechanisms of action and discuss the design of universal influenza vaccines inspired by bnAbs.</span></p></div>\",\"PeriodicalId\":11082,\"journal\":{\"name\":\"Current opinion in virology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2022-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1879625722000141\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in virology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1879625722000141","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}
Broad neutralizing antibody-based strategies to tackle influenza
Influenza viruses cause occasional pandemics and annual epidemics, thus persist as a threat to human society. The high variability of viral envelope proteins resulting from antigenic shift and antigenic drift allows influenza viruses to escape human herd immunity. During the past decade, along with the breakthroughs of human monoclonal antibody technologies, many broad reactive monoclonal antibodies (mAbs) that neutralize diverse influenza subtypes have been isolated and characterized. The achievements in this field have provided potential candidates of anti-influenza therapeutics and shed light on the design of universal influenza vaccines. Here, we review the broad neutralizing antibodies (bnAbs) targeting the virus surface proteins, summarize their epitopes, broad spectrum and immunological mechanisms of action and discuss the design of universal influenza vaccines inspired by bnAbs.
期刊介绍:
Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.