全身性高氧条件下全速冲刺间歇运动的激素、代谢和血管生成反应

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2022-04-01 DOI:10.1016/j.ghir.2022.101445
Michihiro Kon , Yoshiko Ebi , Kohei Nakagaki
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引用次数: 0

摘要

目的运动时高氧气体吸入可能对全速冲刺间歇运动(SIE)诱导的激素、代谢和血管生成反应产生负面影响。我们研究了全身高氧条件下急性全面SIE对激素、代谢和血管生成反应的影响。这是一项随机交叉试验。健康男性10例(年龄平均±标准误差= 23.1±0.9岁;高度= 171.0±1.6 cm;体重= 66.2±2.0 kg;体重指数= 22.6±0.5 kg/m2)完成了两个实验方案:1)常氧下SIE和2)全身高氧(FiO2 = 60%)下SIE。受试者进行了四组30秒的最大自行车运动,每次运动之间的恢复时间为4分钟。在两种治疗方案开始前和治疗后0分钟(治疗后立即)、30分钟和120分钟测量激素(生长激素、肾上腺素和去甲肾上腺素)、代谢(葡萄糖、游离脂肪酸和乳酸)和血管生成(血管内皮生长因子、基质金属蛋白酶-2和-9、内皮抑素)标志物的循环水平。结果在两种SIE方案的反应中,间歇运动期间的峰值和平均功率输出与第一回合相比逐渐下降(p <0.01),两组间无显著差异。两种方案都显著增加了所有激素、代谢和血管生成标志物的循环浓度(p <0.01)。然而,在两种方案的任何时间点,这些标志物的水平没有显著差异(p >0.05)。结论急性全身性高氧不影响全负荷SIE的激素、代谢和血管生成反应。
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Hormonal, metabolic, and angiogenic responses to all-out sprint interval exercise under systemic hyperoxia

Objective

Hyperoxic gas inhalation during exercise may negatively affect all-out sprint interval exercise (SIE)-induced hormonal, metabolic, and angiogenic responses. We investigated the effects of acute all-out SIE under systemic hyperoxia on hormonal, metabolic, and angiogenic responses.

Design

This was a randomised-crossover trial. Ten healthy males (mean ± standard error of age = 23.1 ± 0.9 years; height = 171.0 ± 1.6 cm; body mass = 66.2 ± 2.0 kg; body mass index = 22.6 ± 0.5 kg/m2) completed the following two experimental regimens: 1) SIE under normoxia and 2) SIE under systemic hyperoxia (FiO2 = 60%). The subjects performed four bouts of 30-s maximal cycling efforts with 4 min recovery between efforts. The circulating levels of hormonal (growth hormone, epinephrine, and norepinephrine), metabolic (glucose, free fatty acid, and lactate), and angiogenic (vascular endothelial growth factor, matrix metalloproteinase-2 and -9, and endostatin) markers were measured before and at 0 (immediately after the regimen), 30, and 120 min after both regimens.

Results

In response to both SIE regimens, the peak and mean power outputs gradually decreased over the intermittent exercise session compared with those in the first bout (p < 0.01) with no significant differences between the regimens. Both regimens significantly increased the circulating concentrations of all hormonal, metabolic, and angiogenic markers (p < 0.01). However, there were no significant differences in the levels of these markers in response to the two regimens at any time point (p > 0.05).

Conclusion

These findings suggest that acute systemic hyperoxia does not influence the hormonal, metabolic, and angiogenic responses to all-out SIE.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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