C Benk, G Trummer, J-S Pooth, C Scherer, F Beyersdorf
{"title":"[卡尔控制全身再灌注]。","authors":"C Benk, G Trummer, J-S Pooth, C Scherer, F Beyersdorf","doi":"10.1007/s00398-022-00491-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The incidence and mortality of acute cardiovascular arrest have been consistently high for decades.</p><p><strong>Objective: </strong>How to improve the currently unsatisfactory outcome after resuscitation regarding survival and neurological, especially cerebral, sequelae?</p><p><strong>Material and methods: </strong>Development of a therapeutic approach to curtail ischemia/reperfusion injury in an animal model. Development of a device system optimized for resuscitation that can be used to implement controlled reperfusion of the whole body outside the hospital.</p><p><strong>Results: </strong>Establishment of CARL treatment in the clinic and in the treatment of OHCA patients. Transfer of the CARL treatment and system in a clinical observational study. First case reports in which patients survived OHCA without brain damage even after ischemia times up to 2 h.</p><p><strong>Conclusion: </strong>CARL treatment is potentially suitable to treat patients suffering from cardiovascular arrest refractory to treatment even for prolonged periods.</p>","PeriodicalId":52066,"journal":{"name":"Zeitschrift fur Herz Thorax und Gefasschirurgie","volume":"36 2","pages":"100-106"},"PeriodicalIF":0.1000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856600/pdf/","citationCount":"0","resultStr":"{\"title\":\"[CARL-Controlled reperfusion of the whole body].\",\"authors\":\"C Benk, G Trummer, J-S Pooth, C Scherer, F Beyersdorf\",\"doi\":\"10.1007/s00398-022-00491-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The incidence and mortality of acute cardiovascular arrest have been consistently high for decades.</p><p><strong>Objective: </strong>How to improve the currently unsatisfactory outcome after resuscitation regarding survival and neurological, especially cerebral, sequelae?</p><p><strong>Material and methods: </strong>Development of a therapeutic approach to curtail ischemia/reperfusion injury in an animal model. Development of a device system optimized for resuscitation that can be used to implement controlled reperfusion of the whole body outside the hospital.</p><p><strong>Results: </strong>Establishment of CARL treatment in the clinic and in the treatment of OHCA patients. Transfer of the CARL treatment and system in a clinical observational study. First case reports in which patients survived OHCA without brain damage even after ischemia times up to 2 h.</p><p><strong>Conclusion: </strong>CARL treatment is potentially suitable to treat patients suffering from cardiovascular arrest refractory to treatment even for prolonged periods.</p>\",\"PeriodicalId\":52066,\"journal\":{\"name\":\"Zeitschrift fur Herz Thorax und Gefasschirurgie\",\"volume\":\"36 2\",\"pages\":\"100-106\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856600/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Herz Thorax und Gefasschirurgie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00398-022-00491-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/2/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Herz Thorax und Gefasschirurgie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00398-022-00491-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/2/18 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Background: The incidence and mortality of acute cardiovascular arrest have been consistently high for decades.
Objective: How to improve the currently unsatisfactory outcome after resuscitation regarding survival and neurological, especially cerebral, sequelae?
Material and methods: Development of a therapeutic approach to curtail ischemia/reperfusion injury in an animal model. Development of a device system optimized for resuscitation that can be used to implement controlled reperfusion of the whole body outside the hospital.
Results: Establishment of CARL treatment in the clinic and in the treatment of OHCA patients. Transfer of the CARL treatment and system in a clinical observational study. First case reports in which patients survived OHCA without brain damage even after ischemia times up to 2 h.
Conclusion: CARL treatment is potentially suitable to treat patients suffering from cardiovascular arrest refractory to treatment even for prolonged periods.
期刊介绍：
Die Zeitschrift für Herz-, Thorax- und Gefäßchirurgie ist als Offizielles Weiterbildungsorgan der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie (DGTHG) die Informationsplattform für die entscheidenden Entwicklungen des Fachgebietes. Sie richtet sich an junge Ärzt*innen in der Weiterbildung und an Spezialist*innen, die up-to-date bleiben wollen.
Die Zeitschrift bietet State-of-the-Art-Chirurgie von der Indikation bis zur Nachbehandlung, aktuelle chirurgische und technologische Trends und Informationen über neue Forschungsrichtungen. Kernstück jeder Ausgabe sind Arbeiten in den Rubriken „Übersichten“ und „Operative Techniken“, Kasuistiken zeigen ungewöhnliche Krankheits- bzw. Behandlungsverläufe oder widmen sich juristischen Fragestellungen. In der Rubrik „Im Brennpunkt“ kommentieren Expert*innen herausragende Publikationen aus der internationalen Fachliteratur.
Beiträge der Rubrik „CME Zertifizierte Fortbildung“ bieten gesicherte Ergebnisse wissenschaftlicher Forschung und machen ärztliche Erfahrung für die tägliche Praxis nutzbar Zur Wissensüberprüfung und zum Erwerb von CME-Punkten stehen Online-Kurse zur Verfügung. Die Rubrik orientiert sich an der Weiterbildungsordnung des Fachgebiets.
Abwechselnd erscheinen Beiträge aus den Rubriken: Evidenzbasierte Medizin, Perioperative Medizin, Kardiotechnik/EKZ, Krankenhausmanagement, Nachbardisziplinen, Stand der Wissenschaft, Karriere und Perspektiven.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
