COVID-19家族聚集性视网膜色素变性和低γ球蛋白血症。

IF 2.1 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of Thoracic Medicine Pub Date : 2022-01-01 Epub Date: 2022-01-14 DOI:10.4103/atm.atm_520_21

Abeer N Alshukairi, Yasser A Aldabbagh, Najla M Sayes, Manal M Al Gethamy, Mohammed G Alghamdi, Zuhair A Rahbeeni, Ashraf Dada

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引用次数: 0

摘要

低丙种球蛋白血症是先天性和获得性抗体缺乏的异质组，具有不同的疾病严重程度，复发性肺炎和支气管扩张。低丙种球蛋白血症患者感染COVID的结果因年龄、合并症、免疫缺陷类型和免疫球蛋白的使用而异。我们报告了两名被诊断为dnajc17相关视网膜色素变性和低γ球蛋白血症综合征的家庭成员，并在与其患有COVID-19的母亲接触后感染了SARS-CoV-2。我们描述了这些患者的不同免疫功能障碍及其对SARS-CoV-2感染过程和管理的影响。

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A COVID-19 family cluster with retinitis pigmentosa and hypogammaglobulinemia.

Hypogammaglobulinemia is a heterogeneous group of innate and acquired antibody deficiency with variable disease severity, recurrent pneumonia, and bronchiectasis. The outcome of COVID in patients with hypogammaglobulinemia is variable depending on age, comorbidities, type of immunodeficiency, and use of immunoglobulins. We report the favorable outcome of two family members diagnosed with DNAJC17-related retinitis pigmentosa and hypogammaglobulinemia syndrome and infected with SARS-CoV-2 following contact with their mother who had COVID-19. We describe the different immune dysfunction in these patients and their impact on the course and management of SARS-CoV-2 infection.

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来源期刊

Annals of Thoracic Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-RESPIRATORY SYSTEM

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： The journal will cover studies related to multidisciplinary specialties of chest medicine, such as adult and pediatrics pulmonology, thoracic surgery, critical care medicine, respiratory care, transplantation, sleep medicine, related basic medical sciences, and more. The journal also features basic science, special reports, case reports, board review , and more. Editorials and communications to the editor that explore controversial issues and encourage further discussion by physicians dealing with chest medicine.