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Prolonged viral shedding following COVID-19 infection in a rheumatoid patient on rituximab treatment 一名接受利妥昔单抗治疗的类风湿患者感染 COVID-19 后病毒长期脱落
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_298_23
Aqsa Zahid, Ahmed Fahim, Latika Gupta, Ajibade Adenitan, Tom Sheeran, Sarah Goddard
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引用次数: 0
Long-term outcome of pulmonary involvement in patients with coronavirus disease 2019: The role of high-resolution computed tomography and functional status – A prospective single-center observational study 2019年冠状病毒疾病患者肺部受累的长期预后:高分辨率计算机断层扫描和功能状态的作用--一项前瞻性单中心观察研究
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_191_23
Sadia Imtiaz, Enas M Batubara, Mohammed H Abuelgasim, Mahdi M Alabad, L. M. Alyousef, N. Alqahtani, Alaa Y Sabbagh, Fawaz A Alharbi, Ahmed S Ibrahim
Since its first outbreak, coronavirus disease 2019 (COVID-19) has led to a great deal of published literature highlighting the short-term determinants of morbidity and mortality. Recently, several studies have reported radiological and functional sequelae from 3 months to 1 year among hospitalized COVID-19 survivors; however, long-term (more than 1 year) respiratory consequences in this population remain to be evaluated. To assess the long-term radiological and pulmonary function outcomes of patients with COVID-19 2 years after resolution of the initial infection. Hospitalized COVID-19 patients with moderate to severe disease who survived acute illness were included in this prospective and partially retrospective study. Clinical assessment, laboratory tests, high-resolution computed tomography scans, and pulmonary function tests (PFTs) were performed at baseline, followed by radiological and lung function assessments at 6 and 24 months. Among 106 enrolled participants (mean age 62 ± 13.5 years; males: 61), 44 (41.5%) and 27 (25.4%) underwent radiological assessment at 6 and 24 months, respectively. Overall, 22.6% (24) of patients had residual radiological abnormalities. Overt fibrosis was observed in 12.2% of patients. Computed tomography disease severity and extent diminished significantly at 6 (13 ± 6, P < 0.001) and 24 months (11 ± 6, P < 0.001) from baseline. PFTs were performed in 65 (61.3%), 22 (20.7%), and 34 (32%) patients at baseline, 6 and 24 months, respectively. Impaired diffusion capacity (median diffusion capacity for carbon monoxide: 60%, interquartile range [IQR]: 51–80), restrictive lung defect (mean total lung capacity: 73.4% ± 18% predicted), and reduced exercise tolerance (median 6-min walk distance: 360 m, IQR: 210–400) were the predominant features at baseline. With the exception of exercise tolerance, a statistically significant improvement was observed in lung function parameters at the extended follow-up (2 years). Hospitalized COVID-19 survivors are at increased risk of developing long-term pulmonary complications, including lung fibrosis. A protocol-based approach to the management of post-COVID-19 patients is mandatory to improve future outcomes.
冠状病毒病 2019(COVID-19)自首次爆发以来,已发表了大量文献,强调了发病率和死亡率的短期决定因素。最近,几项研究报告了 COVID-19 住院幸存者 3 个月至 1 年的放射学和功能后遗症;然而,该人群的长期(1 年以上)呼吸系统后果仍有待评估。 目的:评估 COVID-19 患者在初次感染缓解 2 年后的长期放射学和肺功能结果。 这项前瞻性和部分回顾性研究纳入了急性期存活的中重度 COVID-19 住院患者。在基线期进行临床评估、实验室检查、高分辨率计算机断层扫描和肺功能测试(PFT),然后在 6 个月和 24 个月时进行放射学和肺功能评估。 在 106 名注册参与者(平均年龄为 62 ± 13.5 岁;男性:61 人)中,分别有 44 人(41.5%)和 27 人(25.4%)在 6 个月和 24 个月时接受了放射学评估。总体而言,22.6%(24 人)的患者有残留的放射学异常。12.2%的患者出现了明显的纤维化。与基线相比,计算机断层扫描的疾病严重程度和范围在 6 个月(13 ± 6,P < 0.001)和 24 个月(11 ± 6,P < 0.001)时明显减轻。在基线、6 个月和 24 个月时,分别有 65(61.3%)、22(20.7%)和 34(32%)名患者进行了 PFT 检查。弥散能力受损(一氧化碳弥散能力中位数:60%,四分位数间距 [IQR]:51-80)、限制性肺功能受损(一氧化碳弥散能力中位数:60%,四分位数间距 [IQR]:51-80):基线时的主要特征是肺弥散能力受损(一氧化碳弥散能力中位数:60%,四分位数间距 [IQR]:51-80)、限制性肺缺陷(平均总肺活量:73.4% ± 18% 预测值)和运动耐量降低(6 分钟步行距离中位数:360 米,IQR:210-400)。除运动耐量外,在延长随访时间(2 年)后,肺功能参数均有显著改善。 COVID-19 的住院幸存者发生长期肺部并发症(包括肺纤维化)的风险增加。为改善未来的预后,必须对 COVID-19 后患者采取基于方案的管理方法。
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引用次数: 0
Endobronchial angioleiomyoma: Diagnostic difficulties of a rare lung neoplasm 支气管内血管瘤:罕见肺部肿瘤的诊断难题
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_223_23
Mafalda Orlando, Maurizio Alimandi, Giovanni Monteleone
Angioleiomyoma is a benign soft-tissue tumor that rarely develops in the respiratory tract. Here, we report a case of a 51-year-old female with an angioleiomyoma developed in the left lobar bronchial branch and extended to the left principal bronchus, causing nonspecific symptoms, and not visible on the chest X-ray examination. The suspected diagnosis was established by high-resolution computed tomography and confirmed by the histological evaluation of the endoscopically removed lesion.
血管瘤是一种良性软组织肿瘤,很少发生在呼吸道。在此,我们报告了一例 51 岁女性血管网状肌瘤患者的病例,她的血管网状肌瘤发生在左叶支气管分支,并延伸至左主支气管,引起非特异性症状,胸部 X 光检查也未发现。高分辨率计算机断层扫描确定了疑似诊断,内窥镜切除病灶的组织学评估证实了这一诊断。
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引用次数: 0
Surgical management of acquired benign tracheoesophageal fistula: Technical aspects and suggestions 后天性良性气管食管瘘的手术治疗:技术方面和建议
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_301_23
D. Amore, Dino Casazza, U. Caterino, C. Bergaminelli
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引用次数: 0
Adjuvant surgical resection for nontuberculous mycobacterial pulmonary disease: Effectiveness and complications 非结核分枝杆菌肺病的辅助手术切除:疗效和并发症
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_237_23
Ji Yong Kim, J. Yun, Geon Dong Lee, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Seung-Il Park, Dong Kwan Kim
Standard antibiotic treatment for nontuberculous mycobacteria pulmonary disease (NTMPD) has unsatisfactory success rates. Pulmonary resection is considered adjunctive therapy for patients with refractory disease or severe complications, but surgical indications and extent of resection remain unclear. We present surgical treatment outcomes for NTMPD and analyzes risk factors for unfavorable outcomes. We conducted a retrospective investigation of medical records for patients diagnosed with NTMPD who underwent surgical treatment at Asan Medical Center between 2007 and 2021. We analyzed clinical data including microbiological and surgical outcomes. A total of 71 NTMPD patients underwent thoracic surgery. Negative conversion of acid-fast bacillus (AFB) culture following pulmonary resection was observed in 51 (73.9%) patients. In terms of long-term outcomes, negative conversion was sustained in 38 cases (55.1%). Mortality occurred in 7 patients who underwent pulmonary resections for NTMPD. Statistically significant associations with factors for recurrence or non-negative conversion of AFB culture were found in older age (odds ratio [OR] =1.093, 95% confidence interval [CI]: 1.029–1.161, P = 0.004), male sex (OR = 0.251, 95% CI: 0.071–0.892, P = 0.033), and extensive NTMPD lesions involving three lobes or more (OR = 5.362, 95% CI: 1.315–21.857, P = 0.019). Interstitial lung disease (OR = 13.111, 95% CI: 1.554–110.585, P = 0.018) and pneumonectomy (OR = 19.667, 95% CI: 2.017–191.797, P = 0.018) were statistically significant risk factors for postoperative mortality. Pulmonary resection can be an effective adjuvant treatment option for NTMPD patients, with post-operative antibiotic treatment as the primary treatment. Careful patient selection is crucial, considering the associated risk factors and resectability due to complications and recurrence.
非结核分枝杆菌肺病(NTMPD)的标准抗生素治疗成功率并不令人满意。肺切除术被认为是难治性疾病或严重并发症患者的辅助疗法,但手术指征和切除范围仍不明确。我们介绍了 NTMPD 的手术治疗结果,并分析了不利结果的风险因素。 我们对 2007 年至 2021 年期间在牙山医疗中心接受手术治疗的 NTMPD 患者的病历进行了回顾性调查。我们分析了包括微生物和手术结果在内的临床数据。 共有 71 名 NTMPD 患者接受了胸部手术。51例(73.9%)患者在肺切除术后观察到酸-ast杆菌(AFB)培养阴转。就长期结果而言,38 例(55.1%)患者持续阴转。7例因 NTMPD 而接受肺切除术的患者出现了死亡。据统计,年龄越大,AFB 培养复发或转阴的几率越大(几率比 [OR] =1.093,95% 置信区间 [CI]:1.029-1.161):1.029-1.161, P = 0.004)、男性(OR = 0.251, 95% CI: 0.071-0.892, P = 0.033)和涉及三个或三个以上肺叶的广泛 NTMPD 病变(OR = 5.362, 95% CI: 1.315-21.857, P = 0.019)。间质性肺病(OR = 13.111,95% CI:1.554-110.585,P = 0.018)和肺切除术(OR = 19.667,95% CI:2.017-191.797,P = 0.018)是术后死亡率的显著危险因素。 肺切除术可作为 NTMPD 患者的有效辅助治疗方案,术后抗生素治疗为主要治疗手段。考虑到相关风险因素以及并发症和复发导致的可切除性,谨慎选择患者至关重要。
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引用次数: 0
Continuous positive airway pressure combined with small-tidal-volume ventilation on arterial oxygenation and pulmonary shunt during one-lung ventilation in patients undergoing video-assisted thoracoscopic lobectomy: A randomized, controlled study 持续气道正压联合小潮气量通气对视频辅助胸腔镜肺叶切除术患者单肺通气时动脉氧合和肺分流的影响:随机对照研究
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_240_23
Yudie Yang, Dong Jia, Lu Cheng, Ke Jia, Ji Wang
One-lung ventilation (OLV) is frequently applied during video-assisted thoracoscopic surgery (VATS) airway management to collapse and isolate the nondependent lung (NL). OLV can give rise to hypoxemia as a result of the pulmonary shunting produced. Our study aimed to assess the influence of continuous positive airway pressure (CPAP) combined with small-tidal-volume ventilation on improving arterial oxygenation and decreasing pulmonary shunt rate (QS/QT) without compromising surgical field exposure during OLV. Forty-eight patients undergoing scheduled VATS lobectomy were enrolled in this research and allocated into three groups at random: C group (conventional ventilation, no NL ventilation intervention was performed), LP group (NL was ventilated with lower CPAP [2 cmH2O] and a 40–60 mL tidal volume [TV]), and HP group (NL was ventilated with higher CPAP [5 cmH2O] and a 60–80 mL TV). Record the blood gas analysis data and calculate the QS/QT at the following time: at the beginning of the OLV (T0), 30 min after OLV (T1), and 60 min after OLV (T2). Surgeons blinded to ventilation techniques were invited to evaluate the surgical fields. The demography data of the three groups were consistent with the surgical data. At T1, PaO2 in the HP group was substantially higher compared to the C group (P < 0.05), while there was no significant difference in the LP group (P > 0.05). At T1-T2, PaCO2 in the LP and HP groups was significantly less than that in the C group (P < 0.05). At T1, the QS/QT values of groups C, LP, and HP were 29.54 ± 6.89%, 22.66 ± 2.08%, and 19.64 ± 5.76%, respectively, and the QS/QT values in the LP and HP groups markedly reduced (P < 0.01). The surgical field’s evaluation by the surgeon among the three groups was not notable (P > 0.05). CPAP combined with small-tidal-volume ventilation effectively improved arterial oxygenation and reduced QS/QT and PaCO2 without compromising surgical field exposure during OLV. Among them, 5 cmH2O CPAP + 60–80 ml TV ventilation had a better effect on improving oxygenation.
单肺通气(OLV)是视频辅助胸腔镜手术(VATS)气道管理过程中经常使用的通气方式,目的是使非独立肺(NL)塌陷并与之隔离。由于产生肺分流,OLV 可能导致低氧血症。我们的研究旨在评估持续气道正压(CPAP)结合小潮气量通气对改善动脉氧合和降低肺分流率(QS/QT)的影响,同时不影响 OLV 期间的手术视野暴露。 48 名接受预定 VATS 肺叶切除术的患者被纳入本研究,并被随机分为三组:C 组(常规通气,不进行 NL 通气干预)、LP 组(NL 通气采用较低的 CPAP [2 cmH2O],潮气量 [TV] 为 40-60 mL)和 HP 组(NL 通气采用较高的 CPAP [5 cmH2O],潮气量 [TV] 为 60-80 mL)。在以下时间记录血气分析数据并计算 QS/QT:OLV 开始时(T0)、OLV 结束后 30 分钟(T1)和 OLV 结束后 60 分钟(T2)。邀请对通气技术保密的外科医生对手术区域进行评估。 三组的人口统计学数据与手术数据一致。在 T1,HP 组的 PaO2 明显高于 C 组(P < 0.05),而 LP 组无明显差异(P > 0.05)。在 T1-T2 阶段,LP 组和 HP 组的 PaCO2 明显低于 C 组(P < 0.05)。T1时,C组、LP组和HP组的QS/QT值分别为(29.54 ± 6.89%)、(22.66 ± 2.08%)和(19.64 ± 5.76%),LP组和HP组的QS/QT值明显降低(P < 0.01)。三组外科医生的手术视野评价差异不显著(P > 0.05)。 CPAP 联合小潮气量通气可有效改善动脉氧合,降低 QS/QT 和 PaCO2,同时不影响 OLV 期间的手术视野暴露。其中,5 cmH2O CPAP + 60-80 ml TV 通气对改善氧合有更好的效果。
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引用次数: 0
Association between healthy lifestyles and post-COVID-19 syndrome among college students 大学生健康生活方式与后 COVID-19 综合征之间的关系
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_219_23
Dezhuo Sun, Xiangfei Zhu, Zhonghan Bao, Xiaoping Lin
Post-COVID-19 syndrome still occurs in some populations. A healthy lifestyle is widely recognized as a first-line treatment to increase the body’s antiviral resistance and tissue repair, but it is unclear whether a healthy lifestyle can promote or alleviate the symptoms of post-COVID-19 syndrome. A stratified random sampling method was used to select 498 participants from three universities in Fujian as the target of the questionnaire survey. The survey focused on students’ healthy lifestyles and the symptoms of fatigue, anxiety, dyspnea, and depression that are common in post-COVID-19 syndrome. Two months after developing COVID-19, some students continued to experience fatigue, anxiety, dyspnea, and depression, with fatigue being the most prominent symptom. The results of the study showed that there was a significant negative correlation (P < 0.01) between a healthy lifestyle and fatigue, anxiety, dyspnea, and depression among university students. Furthermore, when analyzing the different subdimensions of healthy lifestyles among university students, it was found that all dimensions showed varying degrees of negative correlation with fatigue, anxiety, dyspnea, and depression, except for health-related behaviors and interpersonal behaviors, which showed no relationship with fatigue (P < 0.01). By improving healthy lifestyles, long-term COVID-19 symptoms can be reduced and improved and contribute positively to patient recovery, providing a viable rehabilitation option for long-term COVID-19 patients.
在一些人群中仍存在后 COVID-19 综合征。健康的生活方式被广泛认为是提高机体抗病毒能力和组织修复能力的一线治疗方法,但健康的生活方式是否能促进或缓解COVID-19后综合征的症状尚不清楚。 本次问卷调查采用分层随机抽样的方法,从福建三所高校中抽取了 498 人作为调查对象。调查主要针对学生的健康生活方式以及 COVID-19 后综合征常见的疲劳、焦虑、呼吸困难和抑郁等症状。 在患 COVID-19 两个月后,部分学生仍有疲劳、焦虑、呼吸困难和抑郁等症状,其中疲劳是最突出的症状。研究结果表明,大学生的健康生活方式与疲劳、焦虑、呼吸困难和抑郁之间存在显著的负相关(P < 0.01)。此外,在分析大学生健康生活方式的不同子维度时发现,除了健康相关行为和人际交往行为与疲劳没有关系(P < 0.01)外,其他维度均与疲劳、焦虑、呼吸困难和抑郁呈不同程度的负相关。 通过改善健康的生活方式,可以减轻和改善长期 COVID-19 的症状,对患者的康复起到积极作用,为长期 COVID-19 患者提供了一种可行的康复选择。
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引用次数: 0
Cost-effective in-house COVID-19 reverse transcription-polymerase chain reaction testing with yeast-derived Taq polymerase 利用源于酵母的 Taq 聚合酶进行经济高效的内部 COVID-19 反转录聚合酶链反应测试
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 DOI: 10.4103/atm.atm_180_23
Mahmoud Zhra, Aljohara Al Saud, Maha Alzayer, Liliane Okdah, Hani Tamim, Hana M. A. Fakhoury, Ahmad Aljada
Despite the decline of the COVID-19 pandemic, there continues to be a persistent requirement for reliable testing methods that can be adapted to future outbreaks and areas with limited resources. While the standard approach of using reverse transcription-polymerase chain reaction (RT-PCR) with Taq polymerase is effective, it faces challenges such as limited access to high-quality enzymes and the presence of bacterial DNA contamination in commercial kits, which can impact the accuracy of test results. This study investigates the production of recombinant Taq polymerase in yeast cells and assesses its crude lysate in a multiplex RT-PCR assay for detecting the SARS-CoV-2 RNA-dependent RNA polymerase (RdRP) and N genes, with human Ribonuclease P serving as an internal control. The unpurified yeast Taq polymerase demonstrates sensitivity comparable to commercially purified bacterial Taq polymerase and unpurified bacterial counterparts in detecting the RdRP and N genes. It exhibits the highest specificity, with 100% accuracy, for the N gene. The specificity for the RdRP gene closely aligns with that of commercially purified bacterial Taq polymerase and unpurified bacterial Taq polymerase. The use of unpurified recombinant yeast Taq polymerase shows promise as a cost-effective approach for conducting in-house COVID-19 RT-PCR testing. By eliminating the need for chromatography purification steps, the production of RT-PCR kits can be streamlined, potentially improving accessibility and scalability, especially in resource-limited settings and future pandemics.
尽管 COVID-19 大流行的影响已经减弱,但人们仍然需要可靠的检测方法,以适应未来的疫情爆发和资源有限的地区。使用 Taq 聚合酶进行反转录聚合酶链反应(RT-PCR)的标准方法虽然有效,但也面临着一些挑战,例如高质量酶的获取途径有限,以及商业试剂盒中存在细菌 DNA 污染,这些都会影响检测结果的准确性。 本研究调查了在酵母细胞中生产重组 Taq 聚合酶的情况,并在多重 RT-PCR 检测中评估了其粗裂解物,以检测 SARS-CoV-2 RNA 依赖性 RNA 聚合酶(RdRP)和 N 基因,并以人类核糖核酸酶 P 作为内部对照。 在检测 RdRP 和 N 基因方面,未纯化的酵母 Taq 聚合酶的灵敏度与商业纯化的细菌 Taq 聚合酶和未纯化的细菌 Taq 聚合酶相当。它对 N 基因的特异性最高,准确率达 100%。对 RdRP 基因的特异性与商业纯化的细菌 Taq 聚合酶和未纯化的细菌 Taq 聚合酶非常接近。 使用未纯化的重组酵母 Taq 聚合酶有望成为进行 COVID-19 RT-PCR 内部测试的一种经济有效的方法。通过省去色谱纯化步骤,RT-PCR 试剂盒的生产可以得到简化,从而有可能提高可获得性和可扩展性,特别是在资源有限的环境和未来的流行病中。
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引用次数: 0
Artificial intelligence in respiratory care: Current scenario and future perspective. 人工智能在呼吸护理中的应用:当前形势与未来展望。
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-04-01 Epub Date: 2024-02-16 DOI: 10.4103/atm.atm_192_23
Saad Al-Anazi, Awad Al-Omari, Safug Alanazi, Aqeelah Marar, Mohammed Asad, Fadi Alawaji, Salman Alwateid

Background: This narrative review aims to explore the current state and future perspective of artificial intelligence (AI) in respiratory care. The objective is to provide insights into the potential impact of AI in this field.

Methods: A comprehensive analysis of relevant literature and research studies was conducted to examine the applications of AI in respiratory care and identify areas of advancement. The analysis included studies on remote monitoring, early detection, smart ventilation systems, and collaborative decision-making.

Results: The obtained results highlight the transformative potential of AI in respiratory care. AI algorithms have shown promising capabilities in enabling tailored treatment plans based on patient-specific data. Remote monitoring using AI-powered devices allows for real-time feedback to health-care providers, enhancing patient care. AI algorithms have also demonstrated the ability to detect respiratory conditions at an early stage, leading to timely interventions and improved outcomes. Moreover, AI can optimize mechanical ventilation through continuous monitoring, enhancing patient comfort and reducing complications. Collaborative AI systems have the potential to augment the expertise of health-care professionals, leading to more accurate diagnoses and effective treatment strategies.

Conclusion: By improving diagnosis, AI has the potential to revolutionize respiratory care, treatment planning, and patient monitoring. While challenges and ethical considerations remain, the transformative impact of AI in this domain cannot be overstated. By leveraging the advancements and insights from this narrative review, health-care professionals and researchers can continue to harness the power of AI to improve patient outcomes and enhance respiratory care practices.

Improvements: Based on the findings, future research should focus on refining AI algorithms to enhance their accuracy, reliability, and interpretability. In addition, attention should be given to addressing ethical considerations, ensuring data privacy, and establishing regulatory frameworks to govern the responsible implementation of AI in respiratory care.

背景:这篇叙述性综述旨在探讨人工智能(AI)在呼吸护理领域的现状和未来前景。目的是深入了解人工智能在该领域的潜在影响:方法:对相关文献和调查研究进行了全面分析,以研究人工智能在呼吸护理领域的应用,并确定其发展领域。分析包括远程监控、早期检测、智能通气系统和协同决策等方面的研究:结果:研究结果凸显了人工智能在呼吸护理领域的变革潜力。人工智能算法在根据患者特定数据制定量身定制的治疗计划方面表现出了良好的能力。使用人工智能驱动的设备进行远程监测,可向医疗服务提供者提供实时反馈,从而加强对患者的护理。人工智能算法还展示了在早期阶段检测呼吸系统状况的能力,从而实现及时干预并改善治疗效果。此外,人工智能还能通过持续监测优化机械通气,提高患者舒适度并减少并发症。人工智能协作系统有可能增强医疗保健专业人员的专业知识,从而提供更准确的诊断和更有效的治疗策略:通过改进诊断,人工智能有可能彻底改变呼吸护理、治疗计划和患者监测。虽然挑战和伦理方面的考虑因素依然存在,但人工智能在这一领域的变革性影响怎么强调都不为过。通过利用本综述中的进展和见解,医疗保健专业人员和研究人员可以继续利用人工智能的力量来改善患者预后并加强呼吸护理实践:根据研究结果,未来的研究应侧重于完善人工智能算法,以提高其准确性、可靠性和可解释性。此外,还应注意解决伦理方面的问题,确保数据隐私,并建立监管框架,以便在呼吸护理领域负责任地实施人工智能。
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引用次数: 0
Corticosteroid treatment for persistent pulmonary infiltrates following COVID-19 infection: Clearing the fog? COVID-19感染后持续肺部浸润的皮质类固醇治疗:拨开迷雾?
IF 2.3 4区 医学 Q1 Medicine Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.4103/atm.atm_121_23
Prince Ntiamoah, Michelle Biehl, Victoria Ruesch, Atul C Mehta, Samar Farha

Background: Systemic corticosteroids have been shown to improve outcomes in severe coronavirus disease 2019 (COVID-19) pneumonia; however, their role in post-COVID-19 persistent lung abnormalities is not well defined. Here, we describe our experience with corticosteroids in patients with persistent lung infiltrates following COVID-19 infection.

Research question: What is the efficacy of systemic corticosteroids in improving lung function and radiological abnormalities in patients following COVID-19 pneumonia?

Study design and methods: This is a single-center retrospective study evaluating patients with persistent respiratory symptoms and abnormal chest computed tomography findings. Patients were divided into two groups based on treatment with corticosteroids: "steroid group" and "nonsteroid group." Clinical data were collected from the electronic medical records.

Results: Between March 2020 and December 2021, 227 patients were seen in the post-COVID-19 pulmonary clinic, of which 75 were included in this study. The mean age was 56 years, 63% were female, and 75% were white. The main physiologic deficit was reduced Diffusing capacity of the Lungs for Carbon Monoxide (DLCO) at 72% (±22). On chest imaging, the most common findings were ground-glass opacities (91%) and consolidation (29%). Thirty patients received corticosteroid (steroid group) and 45 did not (nonsteroid group). Patients treated with corticosteroids had lower DLCO (DLCO [%]: steroid group 63 ± 17, nonsteroid group 78 ± 23; P = 0.005) and all had ground-glass opacities on imaging compared to 84% in the nonsteroid group (P = 0.04). At follow-up, patients in the steroid group (n = 16) had a significant improvement in spirometry and DLCO. In addition, there was a significant improvement with resolution of ground-glass opacities in both the groups (P < 0.05).

Conclusion: The use of systemic corticosteroids in patients with persistent respiratory symptoms and radiological abnormalities post-COVID-19 was associated with significant improvement in pulmonary function testing and imaging. Prospective studies are needed to confirm whether these findings are the effect of corticosteroid therapy or disease evolution over time.

背景:研究表明,全身使用皮质类固醇可改善重症冠状病毒病 2019(COVID-19)肺炎的治疗效果;然而,皮质类固醇在 COVID-19 后持续性肺部异常中的作用尚未明确。在此,我们将介绍皮质类固醇在COVID-19感染后肺部持续浸润患者中的应用经验:研究问题:全身使用皮质类固醇对改善 COVID-19 肺炎患者的肺功能和放射学异常有何疗效?这是一项单中心回顾性研究,评估对象为呼吸道症状持续存在且胸部计算机断层扫描结果异常的患者。根据皮质类固醇治疗情况将患者分为两组:"类固醇组 "和 "非类固醇组"。临床数据来自电子病历:2020 年 3 月至 2021 年 12 月期间,COVID-19 后肺部门诊共接诊 227 例患者,其中 75 例纳入本研究。平均年龄为 56 岁,63% 为女性,75% 为白人。主要的生理缺陷是肺对一氧化碳的弥散能力(DLCO)降低,仅为 72%(±22)。在胸部影像学检查中,最常见的发现是磨玻璃不透明(91%)和合并症(29%)。30 名患者接受了皮质类固醇治疗(类固醇组),45 名患者没有接受皮质类固醇治疗(非类固醇组)。接受皮质类固醇治疗的患者 DLCO 较低(DLCO [%]:类固醇组为 63 ± 17,非类固醇组为 78 ± 23;P = 0.005),所有患者的影像学检查均有磨玻璃不透明,而非类固醇组中有 84% 的患者有磨玻璃不透明(P = 0.04)。在随访中,类固醇组患者(n = 16)的肺活量和 DLCO 有显著改善。此外,两组患者的磨玻璃不透明均有明显改善(P < 0.05):结论:COVID-19 后有持续呼吸道症状和放射学异常的患者使用全身皮质类固醇与肺功能测试和影像学检查的显著改善有关。需要进行前瞻性研究,以确认这些结果是皮质类固醇治疗的效果还是疾病随时间的演变。
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Annals of Thoracic Medicine
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