轻度认知障碍的治疗要点是什么?基于ADASJcog认知功能任务评价的研究。

IF 1.4 Q4 CLINICAL NEUROLOGY Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2021-11-16 eCollection Date: 2021-09-01 DOI:10.1159/000519765
Yoshihiko Yoshii, Akiko Takahashi, Miyuki Ishizawa
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引用次数: 0

摘要

背景/目的:本研究的目的是确定图像显示海马萎缩的程度,以及在治疗轻度认知障碍时应关注哪些认知功能项目。方法:选取66例轻度认知障碍患者,进行1.5年的观察。磁共振成像评估海马萎缩,认知功能通过ADASJcog测试评估。结果:轻度痴呆组4项认知功能障碍存在等级差异,各程度等级均显著增高。正常改善组的记忆和行为功能障碍明显改善,恶化组的记忆、定向和行为功能障碍明显增加。正常改善组海马萎缩程度较恶化组轻。讨论:在轻度认知障碍的早期治疗中,重点关注哪些认知项目需要治疗是很重要的,但目前还没有关于它们的数字报告。由于目前尚不清楚,休克治疗可能会有痴呆进展的风险。很明显,展示它是有意义的,这是方向和行为功能。结论:建议将海马萎缩控制在正常范围内,治疗的重点是在不降低定向功能的前提下改善记忆和行为功能障碍。
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What Are the Key Points of Treatment for Cases of Mild Cognitive Impairment? Based on the Evaluation of Cognitive Function Tasks in the ADASJcog.

Background/aims: The aims of this study were to identify the degree of atrophy of the hippocampus in image findings and which cognitive function items should be focused on when treating mild cognitive impairment.

Methods: A total of 66 cases with mild cognitive impairment were included in the study over a 1.5-year observation period. MR images were used to assess hippocampal atrophy, and cognitive function was assessed by the ADASJcog test.

Results: In the mild dementia group, there was a hierarchical difference in the 4 cognitive impairments in which each degree was significantly higher hierarchically. In the normally improved group, memory and act dysfunction was significantly improved, and in deteriorated cases, memory, orientation, and act dysfunction increased significantly. The normally improved group tended to have lighter hippocampal atrophy than the deteriorating group.

Discussion: In early treatment of mild cognitive impairment, it is important to focus on which cognitive items to treat, but there are no reports that present them numerically. Because it is not clear, there may be a risk that dementia may progress due to stunned treatment. It became clear that it was meaningful to show it, and it was the orientation and act function.

Conclusion: It was suggested that hippocampal atrophy should be kept within the normal range and that the key treatment was mainly to improve memory and act dysfunction without reducing orientation function.

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来源期刊
Dementia and Geriatric Cognitive Disorders Extra
Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health
CiteScore
4.30
自引率
0.00%
发文量
18
审稿时长
9 weeks
期刊介绍: This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .
期刊最新文献
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