中草药(九登山)对偏头痛的影响:一项双盲随机临床试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Integrative Medicine Research Pub Date : 2022-12-01 DOI:10.1016/j.imr.2022.100885

Seyoung Kim , Jihye Seo , Cheol-hyun Kim , Hyun-Kyung Sung , Ho-Yeon Go , Woo Sang Jung , Seungwon Kwon , Minjung Kwak , Sangkwan Lee

{"title":"中草药(九登山)对偏头痛的影响:一项双盲随机临床试验","authors":"Seyoung Kim , Jihye Seo , Cheol-hyun Kim , Hyun-Kyung Sung , Ho-Yeon Go , Woo Sang Jung , Seungwon Kwon , Minjung Kwak , Sangkwan Lee","doi":"10.1016/j.imr.2022.100885","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Migraine is a relatively common disease that has a significant effect on the daily activities of affected individuals. The purpose of this study was to explore the effects of herbal medicine (Jodeungsan, JDS) on migraine.</p></div><div><h3>Methods</h3><p>Sixty-four patients with migraine were recruited and randomized to either the JDS or placebo group at a 1:1 ratio. The subjects received JDS or placebo daily for four weeks. The primary outcome was a change in the number of headache attack days (HADs), and the secondary outcome measures were the headache impact test (HIT), migraine-specific quality of life (MSQoL), the deficiency and excess pattern identification questionnaire (DEPIQ), the cold and heat pattern identification questionnaire (CHPIQ), and the blood stasis pattern questionnaire (BSPQ).</p></div><div><h3>Results</h3><p>In all, 61 of the 64 patients took the investigational drugs for four weeks. The number of HADs did not significantly differ between the JDS and placebo groups at the end of the study. However, the HIT and MSQoL results showed significant improvement over the baseline in both groups.</p></div><div><h3>Conclusions</h3><p>JDS did not have a significant effect on chronic migraine. Larger studies are needed to confirm this result.</p></div><div><h3>Trial registration</h3><p>Clinical Research Information Service (https://cris.nih.go.kr/): KCT0003121.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/c4/main.PMC9440383.pdf","citationCount":"0","resultStr":"{\"title\":\"Effect of herbal medicine (Jodeungsan) on migraine: A double-blind randomized clinical trial\",\"authors\":\"Seyoung Kim , Jihye Seo , Cheol-hyun Kim , Hyun-Kyung Sung , Ho-Yeon Go , Woo Sang Jung , Seungwon Kwon , Minjung Kwak , Sangkwan Lee\",\"doi\":\"10.1016/j.imr.2022.100885\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Migraine is a relatively common disease that has a significant effect on the daily activities of affected individuals. The purpose of this study was to explore the effects of herbal medicine (Jodeungsan, JDS) on migraine.</p></div><div><h3>Methods</h3><p>Sixty-four patients with migraine were recruited and randomized to either the JDS or placebo group at a 1:1 ratio. The subjects received JDS or placebo daily for four weeks. The primary outcome was a change in the number of headache attack days (HADs), and the secondary outcome measures were the headache impact test (HIT), migraine-specific quality of life (MSQoL), the deficiency and excess pattern identification questionnaire (DEPIQ), the cold and heat pattern identification questionnaire (CHPIQ), and the blood stasis pattern questionnaire (BSPQ).</p></div><div><h3>Results</h3><p>In all, 61 of the 64 patients took the investigational drugs for four weeks. The number of HADs did not significantly differ between the JDS and placebo groups at the end of the study. However, the HIT and MSQoL results showed significant improvement over the baseline in both groups.</p></div><div><h3>Conclusions</h3><p>JDS did not have a significant effect on chronic migraine. Larger studies are needed to confirm this result.</p></div><div><h3>Trial registration</h3><p>Clinical Research Information Service (https://cris.nih.go.kr/): KCT0003121.</p></div>\",\"PeriodicalId\":13644,\"journal\":{\"name\":\"Integrative Medicine Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/c4/main.PMC9440383.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Integrative Medicine Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213422022000531\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integrative Medicine Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213422022000531","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

背景:偏头痛是一种相对常见的疾病，对患者的日常活动有显著影响。本研究的目的是探讨中草药(Jodeungsan, JDS)对偏头痛的影响。方法招募64例偏头痛患者，按1:1的比例随机分为JDS组和安慰剂组。受试者每天服用JDS或安慰剂，持续四周。主要结局指标为头痛发作天数(HADs)的变化，次要结局指标为头痛影响试验(HIT)、偏头痛特异性生活质量(MSQoL)、虚虚证型识别问卷(DEPIQ)、寒热证型识别问卷(CHPIQ)和血瘀证型调查问卷(BSPQ)。结果64例患者中，61例患者连续用药4周。在研究结束时，JDS组和安慰剂组的HADs数量没有显著差异。然而，HIT和MSQoL结果显示两组均较基线有显著改善。结论sjds对慢性偏头痛无明显治疗作用。需要更大规模的研究来证实这一结果。临床研究信息服务(https://cris.nih.go.kr/): KCT0003121)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Effect of herbal medicine (Jodeungsan) on migraine: A double-blind randomized clinical trial

Background

Migraine is a relatively common disease that has a significant effect on the daily activities of affected individuals. The purpose of this study was to explore the effects of herbal medicine (Jodeungsan, JDS) on migraine.

Methods

Sixty-four patients with migraine were recruited and randomized to either the JDS or placebo group at a 1:1 ratio. The subjects received JDS or placebo daily for four weeks. The primary outcome was a change in the number of headache attack days (HADs), and the secondary outcome measures were the headache impact test (HIT), migraine-specific quality of life (MSQoL), the deficiency and excess pattern identification questionnaire (DEPIQ), the cold and heat pattern identification questionnaire (CHPIQ), and the blood stasis pattern questionnaire (BSPQ).

Results

In all, 61 of the 64 patients took the investigational drugs for four weeks. The number of HADs did not significantly differ between the JDS and placebo groups at the end of the study. However, the HIT and MSQoL results showed significant improvement over the baseline in both groups.

Conclusions

JDS did not have a significant effect on chronic migraine. Larger studies are needed to confirm this result.

Trial registration

Clinical Research Information Service (https://cris.nih.go.kr/): KCT0003121.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.