{"title":"抗阻运动对接受雄激素剥夺治疗的前列腺癌患者身体成分和身体功能的影响:一项最新的系统综述和荟萃分析","authors":"Siyu Tian, Meng Ding, Hongfu Sun","doi":"10.1080/13685538.2022.2146670","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim of the meta-analysis was to explore effects of resistance exercise (RE) on body composition and physical function in patients with prostate cancer (PCa).</p><p><strong>Data sources: </strong>We searched the electronic databases of Pubmed, Embase, Cochrane, and web of science. Published studies have been collected from these databases. Search terms include <i>resistance training, strength training,</i> RE<i>, androgen suppression therapy, androgen deprivation therapy and</i> PCa, with a deadline of 31 March 2022.</p><p><strong>Main results: </strong>These studies showed significant improvements of body composition(Lean body mass MD: 1.12 95% CI [0.48, 1.76], <i>p</i> < 0.01; Body fat rate MD: -1.12 95% CI [-1.99,-0.24], <i>p</i> < 0.05; Appendicular skeletal mass MD: 0.74 95% CI [0.45, 1.03], <i>p</i> < 0.01) and physical function (leg press MD: 77.95 95% CI [38.90, 117.00], <i>p</i> < 0.01; stair climb MD:-0.30 95% CI [-0.49, -0.12], <i>p</i> < 0.01). In addition, the improvement of Body fat mass (MD: -0.21 95% CI [-0.79, 0.37], <i>p</i> > 0.05), 400 m walk (MD: -21.74 95% CI [-45.53, 2.05], <i>p</i> > 0.05) and times up and go (MD: -0.50 95% CI [-1.03, 0.03], <i>p</i> > 0.05) were not obvious. Subgroup analyses showed that RE for ≥ 6 months (compared with RE intervention for < 6 months) and starting exercise immediately after androgen deprivation therapy (ADT) (compared with delayed exercise after ADT) resulted in more significant improvements in body composition. Furthermore, the results showed that the exercise intensity of 8-12 RM significantly improved body composition.</p><p><strong>Conclusions: </strong>RE seems to be a promising approach in order to improve body composition and physical function in PCa patients to offset their treatment-related side effects. RE should be used as a means of rehabilitation and care for PCa. Starting exercise immediately after ADT and extending exercise time while choosing the right intensity can better improve the patients' body composition and function.</p><p><strong>Registration number: </strong>INPLASY202280019.</p>","PeriodicalId":55542,"journal":{"name":"Aging Male","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of resistance exercise on body composition and physical function in prostate cancer patients undergoing androgen deprivation therapy: an update systematic review and meta-analysis.\",\"authors\":\"Siyu Tian, Meng Ding, Hongfu Sun\",\"doi\":\"10.1080/13685538.2022.2146670\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of the meta-analysis was to explore effects of resistance exercise (RE) on body composition and physical function in patients with prostate cancer (PCa).</p><p><strong>Data sources: </strong>We searched the electronic databases of Pubmed, Embase, Cochrane, and web of science. Published studies have been collected from these databases. Search terms include <i>resistance training, strength training,</i> RE<i>, androgen suppression therapy, androgen deprivation therapy and</i> PCa, with a deadline of 31 March 2022.</p><p><strong>Main results: </strong>These studies showed significant improvements of body composition(Lean body mass MD: 1.12 95% CI [0.48, 1.76], <i>p</i> < 0.01; Body fat rate MD: -1.12 95% CI [-1.99,-0.24], <i>p</i> < 0.05; Appendicular skeletal mass MD: 0.74 95% CI [0.45, 1.03], <i>p</i> < 0.01) and physical function (leg press MD: 77.95 95% CI [38.90, 117.00], <i>p</i> < 0.01; stair climb MD:-0.30 95% CI [-0.49, -0.12], <i>p</i> < 0.01). In addition, the improvement of Body fat mass (MD: -0.21 95% CI [-0.79, 0.37], <i>p</i> > 0.05), 400 m walk (MD: -21.74 95% CI [-45.53, 2.05], <i>p</i> > 0.05) and times up and go (MD: -0.50 95% CI [-1.03, 0.03], <i>p</i> > 0.05) were not obvious. Subgroup analyses showed that RE for ≥ 6 months (compared with RE intervention for < 6 months) and starting exercise immediately after androgen deprivation therapy (ADT) (compared with delayed exercise after ADT) resulted in more significant improvements in body composition. Furthermore, the results showed that the exercise intensity of 8-12 RM significantly improved body composition.</p><p><strong>Conclusions: </strong>RE seems to be a promising approach in order to improve body composition and physical function in PCa patients to offset their treatment-related side effects. RE should be used as a means of rehabilitation and care for PCa. Starting exercise immediately after ADT and extending exercise time while choosing the right intensity can better improve the patients' body composition and function.</p><p><strong>Registration number: </strong>INPLASY202280019.</p>\",\"PeriodicalId\":55542,\"journal\":{\"name\":\"Aging Male\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging Male\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/13685538.2022.2146670\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Male","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13685538.2022.2146670","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
目的:本荟萃分析旨在探讨阻力运动(RE)对前列腺癌(PCa)患者身体成分和身体功能的影响。数据来源:检索Pubmed、Embase、Cochrane、web of science等电子数据库。已发表的研究已从这些数据库中收集。搜索词包括阻力训练、力量训练、RE、雄激素抑制疗法、雄激素剥夺疗法和PCa，截止日期为2022年3月31日。主要结果:体成分(瘦体质量MD: 1.12 95% CI [0.48, 1.76]， p p p p p p > 0.05)、400 m步行(MD: -21.74 95% CI [-45.53, 2.05]， p > 0.05)、起跑次数(MD: -0.50 95% CI [-1.03, 0.03]， p > 0.05)均无明显改善。亚组分析显示，≥6个月的RE(与< 6个月的RE干预相比)和在雄激素剥夺治疗(ADT)后立即开始运动(与ADT后延迟运动相比)可使身体成分得到更显著的改善。此外，结果表明，8-12 RM的运动强度显著改善了身体成分。结论:RE似乎是一种很有前途的方法，可以改善PCa患者的身体成分和身体功能，以抵消其治疗相关的副作用。RE应作为PCa的康复和护理手段。ADT后立即开始运动，延长运动时间，选择合适的运动强度，可以更好地改善患者的身体成分和功能。注册号:INPLASY202280019。
The effects of resistance exercise on body composition and physical function in prostate cancer patients undergoing androgen deprivation therapy: an update systematic review and meta-analysis.
Objective: The aim of the meta-analysis was to explore effects of resistance exercise (RE) on body composition and physical function in patients with prostate cancer (PCa).
Data sources: We searched the electronic databases of Pubmed, Embase, Cochrane, and web of science. Published studies have been collected from these databases. Search terms include resistance training, strength training, RE, androgen suppression therapy, androgen deprivation therapy and PCa, with a deadline of 31 March 2022.
Main results: These studies showed significant improvements of body composition(Lean body mass MD: 1.12 95% CI [0.48, 1.76], p < 0.01; Body fat rate MD: -1.12 95% CI [-1.99,-0.24], p < 0.05; Appendicular skeletal mass MD: 0.74 95% CI [0.45, 1.03], p < 0.01) and physical function (leg press MD: 77.95 95% CI [38.90, 117.00], p < 0.01; stair climb MD:-0.30 95% CI [-0.49, -0.12], p < 0.01). In addition, the improvement of Body fat mass (MD: -0.21 95% CI [-0.79, 0.37], p > 0.05), 400 m walk (MD: -21.74 95% CI [-45.53, 2.05], p > 0.05) and times up and go (MD: -0.50 95% CI [-1.03, 0.03], p > 0.05) were not obvious. Subgroup analyses showed that RE for ≥ 6 months (compared with RE intervention for < 6 months) and starting exercise immediately after androgen deprivation therapy (ADT) (compared with delayed exercise after ADT) resulted in more significant improvements in body composition. Furthermore, the results showed that the exercise intensity of 8-12 RM significantly improved body composition.
Conclusions: RE seems to be a promising approach in order to improve body composition and physical function in PCa patients to offset their treatment-related side effects. RE should be used as a means of rehabilitation and care for PCa. Starting exercise immediately after ADT and extending exercise time while choosing the right intensity can better improve the patients' body composition and function.
期刊介绍：
The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year.
The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to:
Diagnosis and treatment of late-onset hypogonadism
Metabolic syndrome and related conditions
Treatment of erectile dysfunction and related disorders
Prostate cancer and benign prostate hyperplasia.
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