免疫组织化学在经典霍奇金淋巴瘤微环境评估中的作用。

IF 1.1 Q4 ONCOLOGY International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01
Dominique Fonseca Rodrigues Lacet, Cristiano Claudino Oliveira
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引用次数: 0

摘要

经典霍奇金淋巴瘤(CHL)具有独特的细胞组成,在炎症背景下含有少数肿瘤细胞-霍奇金和里德-斯特恩伯格(HRS)细胞。对这一微环境的研究在血液病科学中具有特殊的重要性,在阐明其组成及其与患者预后的关系方面发挥着重要作用。目的:研究CHL的微环境肿瘤标志物,以分析其与肿瘤血液病理相关的临床形态学方面的相互作用。方法:回顾性分析184例经病理诊断为CHL的患者。从医疗记录中审查了临床数据。进行CD20、CD30、CD15、PAX-5、CD3、CD4、CD8、CD68、CD34、CD138和PD-1的形态学和免疫表型研究。将数据制成表格,p值小于0.05为显著性。结果:CD20+患者的治愈时间较短,特别是在25%以上阳性的患者中(P=0.0183)。PD-1阴性患者的治愈时间(P=0.0309)和死亡率(P=0.016)较阴性患者短。在微环境中存在浆细胞的患者中,浆细胞数量越少,治愈越早(P=0.0374)。较高的血管密度与较低的B症状发生率(P=0.036)和疾病复发率(P=0.004)相关。结论:微环境无疑是越来越强大的研究的背景,本工作的发现强调了非肿瘤性B淋巴细胞、浆细胞、PD-1淋巴细胞和血管密度与CHL患者预后的关系。
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The role of immunohistochemistry in the assessment of classical Hodgkin lymphoma microenvironment.

Introduction: Classical Hodgkin lymphoma (CHL) has a unique cellular composition, containing a minority of neoplastic cells - Hodgkin and Reed-Sternberg (HRS) cells - in an inflammatory background. Investigations into this microenvironment have been given special importance in scientific hematopathology, playing an important role in elucidating its composition and its relationship to the prognosis of patients.

Objective: To investigate microenvironment tumor markers in CHL, in order to analyze their interactions with clinical-morphological aspects of interest in onco-hematopathology.

Methods: This retrospective study analyzed 184 patients with a pathologic diagnosis of CHL. Clinical data were reviewed from medical records. A morphological and immunophenotypic study with CD20, CD30, CD15, PAX-5, CD3, CD4, CD8, CD68, CD34, CD138 and PD-1 were performed. The data were tabulated and p value less than 0.05 was considered significant.

Results: The time-to-cure was shorter in CD20+ patients, especially in those with more than 25% positivity (P=0.0183). The time-to-cure (P=0.0309) and the death (P=0.016) rates were shorter in PD-1 negative patients. Among patients with the presence of plasma cells in the microenvironment, those with lower numbers tend to be cured earlier (P=0.0374). Higher vascular density is associated with lower frequency of B symptoms (P=0.036) and presence of disease recurrence (P=0.004).

Conclusions: The microenvironment is certainly the setting of increasingly robust studies and the findings of this work highlight non-neoplastic B lymphocytes, plasma cells, PD-1 lymphocytes, and vascular density, related to prognosis of CHL patients.

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来源期刊
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审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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