Anne Castermans, Julie Hias, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy
{"title":"[1例阿托伐他汀肝毒性:寻找可能的病因]。","authors":"Anne Castermans, Julie Hias, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy","doi":"10.36613/tgg.1875-6832/2022.03.03","DOIUrl":null,"url":null,"abstract":"<p><p>We describe a case of a geriatric patient with repeated hepatotoxicity after (re)start of atorvastatin. We also noticed an increased effect, a fast decline of LDL-cholesterol, after intake of atorvastatin. The intake of rosuvastatin or low dose lovastatin was not associated with hepatotoxicity. Multiple hypotheses were investigated and applied on the case. Genetic testing of statin transporters and CYP-enzymes and medication interactions could not explain the hepatotoxicity.</p>","PeriodicalId":39945,"journal":{"name":"Tijdschrift voor Gerontologie en Geriatrie","volume":"53 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"[Case of hepatotoxicity of atorvastatin: the search for a possible etiology].\",\"authors\":\"Anne Castermans, Julie Hias, Lorenz Van der Linden, Isabel Spriet, Jos Tournoy\",\"doi\":\"10.36613/tgg.1875-6832/2022.03.03\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We describe a case of a geriatric patient with repeated hepatotoxicity after (re)start of atorvastatin. We also noticed an increased effect, a fast decline of LDL-cholesterol, after intake of atorvastatin. The intake of rosuvastatin or low dose lovastatin was not associated with hepatotoxicity. Multiple hypotheses were investigated and applied on the case. Genetic testing of statin transporters and CYP-enzymes and medication interactions could not explain the hepatotoxicity.</p>\",\"PeriodicalId\":39945,\"journal\":{\"name\":\"Tijdschrift voor Gerontologie en Geriatrie\",\"volume\":\"53 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tijdschrift voor Gerontologie en Geriatrie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36613/tgg.1875-6832/2022.03.03\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Nursing\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tijdschrift voor Gerontologie en Geriatrie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36613/tgg.1875-6832/2022.03.03","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Nursing","Score":null,"Total":0}
[Case of hepatotoxicity of atorvastatin: the search for a possible etiology].
We describe a case of a geriatric patient with repeated hepatotoxicity after (re)start of atorvastatin. We also noticed an increased effect, a fast decline of LDL-cholesterol, after intake of atorvastatin. The intake of rosuvastatin or low dose lovastatin was not associated with hepatotoxicity. Multiple hypotheses were investigated and applied on the case. Genetic testing of statin transporters and CYP-enzymes and medication interactions could not explain the hepatotoxicity.
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