Glypican-3免疫染色增加与结直肠癌患者更长的生存期相关。

IF 0.7 4区医学 Q4 PATHOLOGY Polish Journal of Pathology Pub Date : 2022-01-01 DOI:10.5114/pjp.2022.117172

Jaudah Al-Maghrabi, Zuhoor Al-Mansouri, Abdullah Al-Harbi, Mourad Assidi, Abdelbaset Buhmeida, Wafaey Gomaa

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引用次数: 1

摘要

Glypicans (GPC)参与细胞信号的发育、形态发生和调控过程。在不同的癌症类型中都观察到异常表达。137例结直肠癌(CRC)和44例淋巴结转移瘤被用于创建组织微阵列。免疫组织化学检测和评估GPC-3蛋白免疫染色模式在结直肠癌中的影响。GPC-3免疫染色在结直肠癌和淋巴结转移中升高(p

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Increased Glypican-3 immunostaining is associated with longer survival outcomes in colorectal carcinoma.

Glypicans (GPC) are involved in the developmental morphogenesis and regulatory processes of cell signalling. Abnormal expression has been observed in different cancer types. One hundred and thirty-seven colorectal carcinoma (CRC) and 44 nodal metastases were used to create tissue microarrays. Immunohistochemistry was done to detect and evaluate the impact of immunostaining patterns of GPC-3 protein in CRC. GPC-3 immunostaining is increased in CRC and nodal metastasis (p < 0.001) and was not association with clinicopathological parameters. GPC-3 immunostaining was associated with longer disease-free survival (p = 0.021) and overall survival (p = 0.05). For the first time, we show GPC-3 immunostaining association with survival outcomes in CRC. GPC-3 may be used as an independent prognostic factor for survival in CRC.

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来源期刊

Polish Journal of Pathology PATHOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.