An anaphylactic reaction after simultaneous injection of hyaluronic acid fillers and human collagen.

Anaphylaxis is rare following the injection of hyaluronic acid fillers or human collagen for esthetic improvement of the face. We report a case occurring in a 63-year-old woman treated simultaneously with both. Symptoms included full-body urticaria and gastrointestinal symptoms that declined within a few hours, facial redness and swelling lasting a few days, and a nodule in the right tear trough that recurred over several months. Treatment with corticosteroids and antihistamine ultimately supported a complete recovery. Although rare, practitioners using injectables should be trained to manage anaphylactic events if they occur.