新型自组装功能化碳纳米管选择性靶向肿瘤的潜力。

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2022-05-01 Epub Date: 2022-07-21 DOI:10.4155/ppa-2022-0001
Chetan D Sabanis, Bharathi R Kannan, Ramesh Joga, Simran, Sandeep Kumar, Neeraj Kumar
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引用次数: 1

摘要

传统的癌症治疗与对健康细胞的毒性有关,这需要通过新的治疗方法来解决。US2021/0230592专利申请公开了一种基于碳纳米管的肿瘤靶向方法,其中开发了一种自组装的单壁纳米管复合物,并将其功能化以向癌细胞传递分子。放射性标记的纳米管表现出明显降低的毒性,因为它们没有描述任何“过度毒性”,直到放射性值为1350 nCi。单壁碳纳米管缀合物与几种螯合剂、治疗性或诊断性放射性核素共价连接,在有效的癌症治疗中显示出有希望的结果。此外,本发明经进一步修改,为研究人员有效诊断和治疗癌症铺平了理想的途径。
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Potential of novel self-assembled functionalized carbon nanotubes for selective tumor targeting.

Conventional cancer therapies are associated with toxicity toward healthy cells, which need to be addressed by novel therapeutic approaches. US2021/0230592 patent application discloses a carbon nanotube-based approach for tumor targeting, wherein a self-assembling single-wall nanotube complex has been developed and functionalized to deliver a molecule to a cancerous cell. The radiolabeled nanotubes exhibited markedly reduced toxicity as they did not depict any 'over toxicity' up to radioactivity value of 1350 nCi. The single-wall carbon nanotube conjugates were covalently connected to several chelators, therapeutic or diagnostic radionuclides, and showed promising results in the effective cancer management. Besides, this invention with further modifications paves an ideal pathway to researchers in effective diagnosis and treatment of cancer.

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Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
自引率
0.00%
发文量
22
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