在阿尔茨海默病中腰椎穿刺的使用和安全性建议:一个简单的语言总结。

IF 2.3 Q3 CLINICAL NEUROLOGY Neurodegenerative disease management Pub Date : 2022-10-01 Epub Date: 2022-07-22 DOI:10.2217/nmt-2022-0012
Harald Hampel, Aya Elhage, Leslie M Shaw, Paul Aisen, Christopher Chen, Alberto Lleó, Takeshi Iwatsubo, Atsushi Iwata, Masahito Yamada, Takeshi Ikeuchi, Jianping Jia, Huali Wang, Charlotte E Teunissen, Elaine Peskind, Kaj Blennow, Jeffrey Cummings, Andrea Vergallo
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引用次数: 3

摘要

这个总结是关于什么的?这是发表在《阿尔茨海默病与痴呆症》杂志上的一篇文章的简明扼要的总结。它着眼于一种被称为腰椎穿刺(也称为脊髓穿刺)的测试,这种测试用于怀疑患有阿尔茨海默病或其他形式的痴呆症的人。这篇总结的重点是如何安全地做腰椎穿刺。为什么这很重要?阿尔茨海默病是一种进行性疾病,这意味着它会随着时间的推移而恶化。这会导致思考和记忆方面的困难。患有阿尔茨海默病的人大脑中淀粉样蛋白-β和tau蛋白的含量增加。随之而来的是脑细胞和大脑功能的逐渐丧失。大脑的变化被认为在症状出现前几年就发生了。腰椎穿刺是一种收集脑脊液样本的医疗程序。在阿尔茨海默病中,它被用来检查脑脊液生物标志物,帮助诊断疾病。腰椎穿刺传统上被认为是一种痛苦和侵入性的手术,而且经常有副作用。然而,多项研究表明,腰椎穿刺可以安全进行。副作用通常是轻微的,不需要专家干预。关键的收获是什么?尽管与腰椎穿刺相关的严重并发症的风险很低,但医生和他们的患者可能不愿意推荐或接受这种手术。患者教育、专家培训以及有关患者安全的新方法是支持腰椎穿刺在阿尔茨海默病中广泛应用的重要因素。
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The use of lumbar puncture and safety recommendations in Alzheimer's disease: a plain language summary.

What is this summary about?: This is a plain language summary of an article published in Alzheimer's & Dementia. It looks at a type of test called a lumbar puncture (also known as spinal tap) used in people suspected of having Alzheimer's disease or some other form of dementia. This summary focuses on how to do a lumbar puncture safely.

Why is this important?: Alzheimer's disease is a progressive condition, which means it gets worse over time. This leads to difficulties with thinking and memory. People with Alzheimer's disease show a build up of proteins called amyloid-β and tau in the brain. This is followed by a gradual loss of brain cells and brain function. The changes in the brain are thought to occur years before symptoms appear. Lumbar puncture is a medical procedure during which samples of cerebrospinal fluid are collected. In Alzheimer's disease, it is used to examine cerebrospinal fluid biomarkers that can help diagnose disease. Lumbar puncture is traditionally considered as a painful and invasive procedure with frequent side effects. However, multiple studies indicate that a lumbar puncture can be performed safely. Side effects are typically mild and do not require specialist intervention.

What are the key takeaways?: Despite the low risk of serious complications associated with a lumbar puncture, physicians and their patients may be reluctant to recommend or undergo this procedure. Patient education, specialist training, as well as new methods concerning patient safety are important factors to support the widespread use of lumbar puncture in Alzheimer's disease.

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