{"title":"阳极氧化和亚临界水氧化法降解异烟肼:Box-Behnken设计的应用。","authors":"Özkan Görmez, Selda Doğan Çalhan, Belgin Gözmen","doi":"10.1080/26896583.2022.2026192","DOIUrl":null,"url":null,"abstract":"<p><p>Pharmaceutical compounds released into the aquatic environment are known to cause toxic effects on the environment. Isoniazid is widely used in the treatment of tuberculosis and is, therefore, frequently encountered in environmental waters. In this study, the degradation of isoniazid was investigated by anodic oxidation and subcritical water oxidation method which are members of Advanced Oxidation Processes. The Box-Behnken Design was used to determine the effects of current, initial concentration, and electrolysis time on mineralization in the anodic oxidation process, which carried out a cell with a Pt cathode and boron-doped diamond anode. The highest mineralization value of 78.14% was achieved at optimal conditions of 300 mA, 3 h, and 100 mg/L initial concentration. The degradation of Isoniazid was also investigated under subcritical water conditions using an ecological oxidizing agent, H<sub>2</sub>O<sub>2</sub>. The maximum mineralization rate of 72.23% was obtained when 100 mM H<sub>2</sub>O<sub>2</sub> was used for a 90 min treatment at 125 °C for 100 mg/L Isoniazid solution in the subcritical water oxidation process. The LC-MS results showed that the degradation products obtained by AO and SWO methods were different from each other. Finally, possible degradation mechanisms are proposed according to the degradation products obtained for both processes.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"40 1","pages":"1-26"},"PeriodicalIF":1.2000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Degradation of isoniazid by anodic oxidation and subcritical water oxidation methods: Application of Box-Behnken design.\",\"authors\":\"Özkan Görmez, Selda Doğan Çalhan, Belgin Gözmen\",\"doi\":\"10.1080/26896583.2022.2026192\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pharmaceutical compounds released into the aquatic environment are known to cause toxic effects on the environment. Isoniazid is widely used in the treatment of tuberculosis and is, therefore, frequently encountered in environmental waters. In this study, the degradation of isoniazid was investigated by anodic oxidation and subcritical water oxidation method which are members of Advanced Oxidation Processes. The Box-Behnken Design was used to determine the effects of current, initial concentration, and electrolysis time on mineralization in the anodic oxidation process, which carried out a cell with a Pt cathode and boron-doped diamond anode. The highest mineralization value of 78.14% was achieved at optimal conditions of 300 mA, 3 h, and 100 mg/L initial concentration. The degradation of Isoniazid was also investigated under subcritical water conditions using an ecological oxidizing agent, H<sub>2</sub>O<sub>2</sub>. The maximum mineralization rate of 72.23% was obtained when 100 mM H<sub>2</sub>O<sub>2</sub> was used for a 90 min treatment at 125 °C for 100 mg/L Isoniazid solution in the subcritical water oxidation process. The LC-MS results showed that the degradation products obtained by AO and SWO methods were different from each other. Finally, possible degradation mechanisms are proposed according to the degradation products obtained for both processes.</p>\",\"PeriodicalId\":53200,\"journal\":{\"name\":\"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis\",\"volume\":\"40 1\",\"pages\":\"1-26\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1080/26896583.2022.2026192\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/26896583.2022.2026192","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/24 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 1
摘要
已知释放到水生环境中的药物化合物会对环境造成毒性作用。异烟肼广泛用于治疗结核病,因此在环境水体中经常遇到。研究了高级氧化法中的阳极氧化法和亚临界水氧化法对异烟肼的降解。采用Box-Behnken设计来确定电流、初始浓度和电解时间对阳极氧化过程中矿化的影响,以铂阴极和掺硼金刚石阳极为电池。在300 mA、3 h、100 mg/L初始浓度条件下,矿化率最高,达78.14%。在亚临界水条件下,采用生态氧化剂H2O2对异烟肼进行了降解研究。100 mg/L异烟肼溶液在亚临界水氧化过程中,以100 mM H2O2在125℃下处理90 min,矿化率达到72.23%。LC-MS结果表明,AO法和SWO法得到的降解产物存在差异。最后,根据两种工艺的降解产物,提出了可能的降解机理。
Degradation of isoniazid by anodic oxidation and subcritical water oxidation methods: Application of Box-Behnken design.
Pharmaceutical compounds released into the aquatic environment are known to cause toxic effects on the environment. Isoniazid is widely used in the treatment of tuberculosis and is, therefore, frequently encountered in environmental waters. In this study, the degradation of isoniazid was investigated by anodic oxidation and subcritical water oxidation method which are members of Advanced Oxidation Processes. The Box-Behnken Design was used to determine the effects of current, initial concentration, and electrolysis time on mineralization in the anodic oxidation process, which carried out a cell with a Pt cathode and boron-doped diamond anode. The highest mineralization value of 78.14% was achieved at optimal conditions of 300 mA, 3 h, and 100 mg/L initial concentration. The degradation of Isoniazid was also investigated under subcritical water conditions using an ecological oxidizing agent, H2O2. The maximum mineralization rate of 72.23% was obtained when 100 mM H2O2 was used for a 90 min treatment at 125 °C for 100 mg/L Isoniazid solution in the subcritical water oxidation process. The LC-MS results showed that the degradation products obtained by AO and SWO methods were different from each other. Finally, possible degradation mechanisms are proposed according to the degradation products obtained for both processes.