注意缺陷多动障碍儿童运动诱导的生长激素分泌减少

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2022-08-01 DOI:10.1016/j.ghir.2022.101485
Dan Nemet , Sigal Ben-Zaken , Roi A. Eliakim , Alon Eliakim
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引用次数: 3

摘要

目的注意缺陷/多动障碍(ADHD)是一种典型的慢性疾病,通常是终生的。数据表明,ADHD本身及其治疗可能与生长失调有关,包括身高和体重指数。这种联系的原因尚不清楚。本研究的目的是检查被诊断为多动症的儿童与年龄和性别匹配的对照组之间生长激素(GH)对运动的反应的差异。我们推断,运动引起的循环生长激素的正常增加在多动症儿童中会减弱。方法:我们招募了13名treatment-naïve新诊断为ADHD的儿童和14名年龄匹配的对照组(均为男性),并测量了GH对运动测试的反应,该测试根据每个受试者的身体能力进行了缩放。结果对照组和ADHD参与者在运动时达到的峰值心率(分别为196.6±1.5 vs. 196.5±2.1 bpm)和运动后的乳酸反应(分别为53.8±5.0 vs. 47.9±3.8 mg/dl)均无差异。运动后,对照组GH显著升高(p <0.005),而生长激素反应在ADHD组明显减弱(p = NS),尽管所做的工作与对照组没有差异。结论sour数据提示ADHD患儿运动刺激后生长激素分泌受损。这可以通过微创、非药物挑战检测到,并且可能将ADHD与某些儿童的生长障碍联系起来。试验注册号:NCT00945971
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Reduced exercise-induced growth hormone secretion among children with attention-deficit hyperactivity disorder

Purpose

Attention-deficit/hyperactivity disorder (ADHD) is typically a chronic, often lifelong condition. Data suggest that ADHD itself and its treatment may be associated with dysregulated growth, including height and BMI. The reason for this association is yet unknown. The objective of this study was to examine differences in growth hormone (GH) response to exercise between children who had received a diagnosis of ADHD and age- and gender-matched controls. We reasoned that the normal increase in circulating GH seen in response to exercise would be blunted in children with ADHD.

Methods

We recruited 13 treatment-naïve children with newly diagnosed ADHD and 14 age-matched controls (all male) and measured GH response to an exercise test in which the work was scaled to each subject's physical capability.

Results

There was no difference in the peak heart rate achieved during exercise between controls and ADHD participants (196.6 ± 1.5 vs. 196.5 ± 2.1 bpm, respectively) and lactate response to exercise (53.8 ± 5.0 vs. 47.9 ± 3.8 mg/dl, respectively). After exercise, GH increased significantly in the control subjects (p < 0.005), while GH responses were substantially blunted in the ADHD group (p = NS) even though the work performed did not differ from controls.

Conclusions

Our data suggest that GH excretion after exercise challenge in children with ADHD is impaired. This can be detected using a minimally invasive, nonpharmacologic challenge and may link ADHD with growth impairment in some children.

Trial registration number: NCT00945971

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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