刚果民主共和国金沙萨妇女乳腺癌的免疫组织化学特征:一项六年回顾性研究

IF 1.6 Q4 ONCOLOGY International Journal of Breast Cancer Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI:10.1155/2022/8860947
Stanislas Maseb'a Mwang Sulu, Donatien Babaka Batalansi, Arnold Maseb Sul Sulu, Olivier Mukuku, Justin Esimo Mboloko, Désiré Kulimba Mashinda, Bienvenu Lebwaze Massamba, Antoine Wola Tshimpi
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引用次数: 1

摘要

基于基因表达和蛋白谱的乳腺癌分子分类使得区分不同的分子亚型成为可能。本研究的目的是描述刚果民主共和国(DRC)金沙萨Nganda医院中心BC浸润妇女的免疫组织化学特征。方法:对2014年至2019年在nanda医院中心登记的190例浸润性BC患者进行回顾性研究。在免疫组织化学研究后,对肿瘤进行组织学分析和分类,分为管腔A型、管腔B型、her2过表达型和三阴性。采用卡方检验来评估年龄、组织学分级和这些亚型之间的关系。结果:以腔内A亚型(44.74%)最为常见,其次为腔内B亚型(40.53%)、三阴性(10.53%)和her2过表达(4.20%)。确诊时患者平均年龄48.27岁。94.21%为导管,2.63%为粘液,2.11%为小叶。其中ⅰ级占68.82%,ⅱ级占28.42%,ⅲ级占3.16%。组织学分级与乳腺癌亚型有显著相关性(p < 0.0001),与年龄无相关性(p = 0.467)。结论:在我们的BC患者中,管腔A是主要的,而her2过表达是最少的。组织学分级和分子亚型之间存在很强的相关性。这些结果对刚果民主共和国的BC控制具有重要的临床和政策意义。
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Immunohistochemical Features of Breast Cancer Seen in Women in Kinshasa, Democratic Republic of the Congo: A Six-Year Retrospective Study.

Introduction: The molecular classification of breast cancer (BC) based on gene expression and then protein profile has made it possible to distinguish different molecular subtypes. The objective of this study was to describe immunohistochemical features of BC infiltrating women at the Nganda Hospital Center in Kinshasa, Democratic Republic of the Congo (DRC).

Methods: A retrospective study from 2014 to 2019 involved 190 patients with invasive BC who were enrolled at the Nganda Hospital Center. The tumors were analyzed histologically and classified after an immunohistochemical study into subtypes: luminal A, luminal B, HER2-overexpressed, and triple-negative. A chi-square test was performed to assess the relationship between age, histological grade, and these subtypes.

Results: The luminal A subtype (44.74%) was the most common, followed by luminal B (40.53%), triple-negative (10.53%), and HER2-overexpressed (4.20%). The mean age of the patients at diagnosis was 48.27 years. Of all cases, 94.21% were ductal, 2.63% were mucinous, and 2.11% were lobular. They were classified as grade I in 68.82% of the cases, grade II in 28.42% of the cases, and grade III in 3.16% of the cases. There was a significant association between histological grade and breast cancer subtypes (p < 0.0001), but no correlation was found with age (p = 0.467).

Conclusion: In our BC patients, the luminal A was predominant, while HER2-overexpressed was the least found. A strong association was noted between histological grade and molecular subtypes. These results should allow for important clinical and policy implications for BC control in the DRC.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
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