DNASE1可变数目串联重复序列和单核苷酸多态性与胃癌的显著关联。

IF 2.7 4区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY British Journal of Biomedical Science Pub Date : 2022-05-13 eCollection Date: 2022-01-01 DOI:10.3389/bjbs.2022.10526
Ali Kafil, Parisa Mohamadynejad, Mehdi Moghanibashi
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引用次数: 0

摘要

凋亡过程中的缺陷是癌变过程中最重要的事件之一,而DNASE1的缺陷作为凋亡机制的组成部分之一,在各种类型的癌症中都起作用。先前的研究表明,不同人群的DNASE1多态性存在显著差异。我们假设DNASE1基因外显子8和内含子4的两个多态性位点与胃癌的风险有关。材料与方法:采用PCR和RFLP-PCR对120例胃癌患者和120例年龄、性别调整对照进行研究。结果:DNASE1第8外显子GG (rs1053874)基因型(优势比[95%置信区间])4.65 [2.10-10.29],p < 0.001)和第4内含子可变数串联重复(VNTR) 2/3基因型(3.75 [1.56-9.01],p = 0.003)均与胃癌相关。结论:我们认为这两个多态性位点在胃癌中都有一定的作用,因此可能是有用的诊断标记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Significant Association of DNASE1 Variable Number Tandem Repeats and Single Nucleotide Polymorphisms With Gastric Cancer.

Introduction: Defects in the apoptotic process are among the most important events involved in carcinogenesis, and defects in DNASE1, as one of the apoptotic machinery components, plays a role in various types of cancer. Previous studies have indicated significant differences in the DNASE1 polymorphisms in different populations. We hypothesized an association of two polymorphic sites in the exon 8 and the intron 4 of the DNASE1 gene with the risk of gastric cancer. Materials and Methods: The study was carried out on 120 gastric cancer patients and 120 age and sex adjusted controls using PCR and RFLP-PCR. Results: The genotype GG (rs1053874) in exon 8 of DNASE1 (odds ratio [95% confidence interval]) 4.65 [2.10-10.29], p < 0.001) and genotype 2/3 of variable number tandem repeat (VNTR) in the intron 4 (3.75 [1.56-9.01], p = 0.003) are both linked to gastric cancer. Conclusion: We propose that both polymorphic sites have a part to play in gastric cancer, and so may be useful diagnosis markers.

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来源期刊
British Journal of Biomedical Science
British Journal of Biomedical Science 医学-医学实验技术
CiteScore
4.40
自引率
15.80%
发文量
29
审稿时长
>12 weeks
期刊介绍: The British Journal of Biomedical Science is committed to publishing high quality original research that represents a clear advance in the practice of biomedical science, and reviews that summarise recent advances in the field of biomedical science. The overall aim of the Journal is to provide a platform for the dissemination of new and innovative information on the diagnosis and management of disease that is valuable to the practicing laboratory scientist.
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