空肠内血肿引起间歇性肠梗阻——华法林毒性的一种罕见表现。

Pub Date : 2022-11-06 eCollection Date: 2022-10-01 DOI:10.1055/s-0042-1755223
Arun S Patil, Shriya Shriya, Nikhil Dhimole, Jalbaji More
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引用次数: 0

摘要

血栓栓塞性疾病患者通常使用抗凝剂;因此,他们容易发生出血发作,如淤血、牙龈出血、结膜下出血,很少有小肠壁内血肿导致患者出现肠梗阻。这是一种罕见的机械性肠梗阻,需要非手术治疗。我们的病人是一名55岁的男性,已知的一例使用华法林治疗的血栓栓塞,表现为腹痛和呕吐。患者实验室报告显示贫血和凝血功能紊乱,凝血酶原时间和国际标准化比值均升高。空肠壁内血肿通过腹部增强计算机断层扫描诊断。保守治疗,停用华法林,给予维生素K。病人接受了新鲜的冷冻血浆和包装细胞血。重要的是要怀疑华法林毒性的患者出现这样的表现,以避免手术治疗,这可能是灾难性的,由于出血过多。定期监测这类患者的凝血状况和减少处方其他可能与华法林相互作用的药物是很重要的。值得注意的是,新型口服抗凝剂,如达比加群和利伐沙班,副作用更少,不需要密切的实验室监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Intramural Jejunal Hematoma Causing Intermittent Bowel Obstruction-A Rare Manifestation of Warfarin Toxicity.

Patients with thromboembolic disorders are commonly on anticoagulants; hence, they are susceptible to bleeding episodes such as ecchymosis, gingival, subconjunctival bleeding, and rarely can have intramural hematoma of small bowel causing patient to present with intestinal obstruction. It is a rare cause of mechanical bowel obstruction requiring a nonsurgical management. Our patient was a 55-year-old male, a known case of thromboembolism on warfarin medication, presented with abdominal pain and vomiting. Patient's laboratory reports reflected anemia and deranged coagulation profile with prothrombin time and international normalized ratio, both being elevated. Intramural hematoma of jejunum was diagnosed by abdominal contrast-enhanced computed tomography. Conservative management was done, warfarin was stopped and vitamin K was administered. Patient received fresh frozen plasma and packed cell blood. It is important to suspect warfarin toxicity in patients on the medication who come with such presentation to avoid surgical management, which could be catastrophic due to excessive bleeding. It is important for regular monitoring of coagulation profile of such patients and to reduce prescribing other medications that can interact with warfarin. It is worth noting that novel oral anticoagulants, such as dabigatran and rivaroxaban, are associated with fewer side effects and do not require close laboratory monitoring.

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