Ali Asadi , Azadeh Akhavanallaf , Seyed Abolfazl Hosseini , Naser Vosoughi , Habib Zaidi
{"title":"开发和验证用于质子铅笔束扫描传输的最佳 GATE 模型","authors":"Ali Asadi , Azadeh Akhavanallaf , Seyed Abolfazl Hosseini , Naser Vosoughi , Habib Zaidi","doi":"10.1016/j.zemedi.2022.10.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To develop and validate a versatile Monte Carlo (MC)-based dose calculation engine to support MC-based dose verification of treatment planning systems (TPSs) and quality assurance (QA) workflows in proton therapy.</p></div><div><h3>Methods</h3><p>The GATE MC toolkit was used to simulate a fixed horizontal active scan-based proton beam delivery (SIEMENS IONTRIS). Within the nozzle, two primary and secondary dose monitors have been designed to enable the comparison of the accuracy of dose estimation from MC simulations with respect to physical QA measurements. The developed beam model was validated against a series of commissioning measurements using pinpoint chambers and 2D array ionization chambers (IC) in terms of lateral profiles and depth dose distributions. Furthermore, beam delivery module and treatment planning has been validated against the literature deploying various clinical test cases of the AAPM TG‐119 (c-shape phantom) and a prostate patient.</p></div><div><h3>Results</h3><p>MC simulations showed excellent agreement with measurements in the lateral depth-dose parameters and spread-out Bragg peak (SOBP) characteristics within a maximum relative error of 0.95 mm in range, 1.83% in entrance to peak ratio, 0.27% in mean point-to-point dose difference, and 0.32% in peak location. The mean relative absolute difference between MC simulations and measurements in terms of absorbed dose in the SOBP region was 0.93% ± 0.88%. Clinical phantom studies showed a good agreement compared to research TPS (relative error for TG-119 planning target volume PTV-D<sub>95</sub> ∼ 1.8%; and for prostate PTV-D<sub>95</sub> ∼ −0.6%).</p></div><div><h3>Conclusion</h3><p>We successfully developed a MC model for the pencil beam scanning system, which appears reliable for dose verification of the TPS in combination with QA information, prior to patient treatment.</p></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"33 4","pages":"Pages 591-600"},"PeriodicalIF":2.4000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0939388922001027/pdfft?md5=ee47ca179f730456d33ac76196b166f2&pid=1-s2.0-S0939388922001027-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Development and validation of an optimal GATE model for proton pencil-beam scanning delivery\",\"authors\":\"Ali Asadi , Azadeh Akhavanallaf , Seyed Abolfazl Hosseini , Naser Vosoughi , Habib Zaidi\",\"doi\":\"10.1016/j.zemedi.2022.10.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To develop and validate a versatile Monte Carlo (MC)-based dose calculation engine to support MC-based dose verification of treatment planning systems (TPSs) and quality assurance (QA) workflows in proton therapy.</p></div><div><h3>Methods</h3><p>The GATE MC toolkit was used to simulate a fixed horizontal active scan-based proton beam delivery (SIEMENS IONTRIS). Within the nozzle, two primary and secondary dose monitors have been designed to enable the comparison of the accuracy of dose estimation from MC simulations with respect to physical QA measurements. The developed beam model was validated against a series of commissioning measurements using pinpoint chambers and 2D array ionization chambers (IC) in terms of lateral profiles and depth dose distributions. Furthermore, beam delivery module and treatment planning has been validated against the literature deploying various clinical test cases of the AAPM TG‐119 (c-shape phantom) and a prostate patient.</p></div><div><h3>Results</h3><p>MC simulations showed excellent agreement with measurements in the lateral depth-dose parameters and spread-out Bragg peak (SOBP) characteristics within a maximum relative error of 0.95 mm in range, 1.83% in entrance to peak ratio, 0.27% in mean point-to-point dose difference, and 0.32% in peak location. The mean relative absolute difference between MC simulations and measurements in terms of absorbed dose in the SOBP region was 0.93% ± 0.88%. Clinical phantom studies showed a good agreement compared to research TPS (relative error for TG-119 planning target volume PTV-D<sub>95</sub> ∼ 1.8%; and for prostate PTV-D<sub>95</sub> ∼ −0.6%).</p></div><div><h3>Conclusion</h3><p>We successfully developed a MC model for the pencil beam scanning system, which appears reliable for dose verification of the TPS in combination with QA information, prior to patient treatment.</p></div>\",\"PeriodicalId\":54397,\"journal\":{\"name\":\"Zeitschrift fur Medizinische Physik\",\"volume\":\"33 4\",\"pages\":\"Pages 591-600\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0939388922001027/pdfft?md5=ee47ca179f730456d33ac76196b166f2&pid=1-s2.0-S0939388922001027-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Medizinische Physik\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0939388922001027\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Medizinische Physik","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0939388922001027","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Development and validation of an optimal GATE model for proton pencil-beam scanning delivery
Objective
To develop and validate a versatile Monte Carlo (MC)-based dose calculation engine to support MC-based dose verification of treatment planning systems (TPSs) and quality assurance (QA) workflows in proton therapy.
Methods
The GATE MC toolkit was used to simulate a fixed horizontal active scan-based proton beam delivery (SIEMENS IONTRIS). Within the nozzle, two primary and secondary dose monitors have been designed to enable the comparison of the accuracy of dose estimation from MC simulations with respect to physical QA measurements. The developed beam model was validated against a series of commissioning measurements using pinpoint chambers and 2D array ionization chambers (IC) in terms of lateral profiles and depth dose distributions. Furthermore, beam delivery module and treatment planning has been validated against the literature deploying various clinical test cases of the AAPM TG‐119 (c-shape phantom) and a prostate patient.
Results
MC simulations showed excellent agreement with measurements in the lateral depth-dose parameters and spread-out Bragg peak (SOBP) characteristics within a maximum relative error of 0.95 mm in range, 1.83% in entrance to peak ratio, 0.27% in mean point-to-point dose difference, and 0.32% in peak location. The mean relative absolute difference between MC simulations and measurements in terms of absorbed dose in the SOBP region was 0.93% ± 0.88%. Clinical phantom studies showed a good agreement compared to research TPS (relative error for TG-119 planning target volume PTV-D95 ∼ 1.8%; and for prostate PTV-D95 ∼ −0.6%).
Conclusion
We successfully developed a MC model for the pencil beam scanning system, which appears reliable for dose verification of the TPS in combination with QA information, prior to patient treatment.
期刊介绍：
Zeitschrift fur Medizinische Physik (Journal of Medical Physics) is an official organ of the German and Austrian Society of Medical Physic and the Swiss Society of Radiobiology and Medical Physics.The Journal is a platform for basic research and practical applications of physical procedures in medical diagnostics and therapy. The articles are reviewed following international standards of peer reviewing.
Focuses of the articles are:
-Biophysical methods in radiation therapy and nuclear medicine
-Dosimetry and radiation protection
-Radiological diagnostics and quality assurance
-Modern imaging techniques, such as computed tomography, magnetic resonance imaging, positron emission tomography
-Ultrasonography diagnostics, application of laser and UV rays
-Electronic processing of biosignals
-Artificial intelligence and machine learning in medical physics
In the Journal, the latest scientific insights find their expression in the form of original articles, reviews, technical communications, and information for the clinical practice.
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