金属离子定向外结合小DNA配体。

Nucleic acids research. Supplement (2001) Pub Date : 2003-01-01 DOI:10.1093/nass/3.1.85

Toshihiro Ihara, Takashi Ikegami, Tomohiro Fujii, Yusuke Kitamura, Shinji Sueda, Makoto Takagi, Nicholas E Geacintov, Akinori Jyo

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引用次数: 3

摘要

含有一个氧和一个吡啶基团的配体的DNA结合受到共存的Cu2+在三个数量级的结合常数范围内的调节。这些配体与Cu2+配合形成二聚体，然后在DNA双链外协同结合，形成沿DNA主链的良好调控的一维结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metal ion-directed outside binding of small DNA ligand.

DNA binding of the ligand bearing an oxine and a pyridinium group was regulated by coexisting Cu2+ over the binding constant range of three orders of magnitude. The ligands coordinated to Cu2+ to form a dimer and then cooperatively bound outside of DNA duplex to give the well-regulated 1-D structure along the DNA backbone.

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Nucleic acids research. Supplement (2001)

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