福莫特罗HFA (Atimos/Forair)在健康志愿者、哮喘和COPD患者中的肺沉积。

Sabine Häussermann, Daniela Acerbi, Peter Brand, Christiane Herpich, Gianluigi Poli, Knut Sommerer, Thomas Meyer
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引用次数: 36

摘要

本研究探讨了肺功能对放射性标记福尔莫特罗HFA MDI (Forair)肺沉积的影响。共测量了18例受试者:6例健康受试者(FEV(1) = 107% pred), 6例哮喘患者(FEV(1) = 72% pred), 6例COPD患者(FEV(1) = 40% pred)。用伽马照相机测量放射性标记药物的肺沉积。健康受试者的肺沉积相对于放射剂量为31%,哮喘患者为34%,COPD患者为35%。这些数据表明,不同人群的肺沉积具有可比性。肺功能(FEV(1))与肺沉积无显著相关性。胸外沉积约50%。结果发现吸入福莫特罗的肺沉积不依赖于肺功能,肺沉积相对较高的数值可以解释为本研究中使用的hfa -福莫特罗制剂的粒径较小(0.8微米),吸入速度较慢(30l /min)。可以得出结论,使用这种现代HFA药物配方,即使在阻塞的肺部,沉积也很高。
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Lung deposition of formoterol HFA (Atimos/Forair) in healthy volunteers, asthmatic and COPD patients.

In this study, the influence of lung function on lung deposition of a radioactively labeled Formotoerol HFA MDI (Forair) was investigated. Eighteen subjects were measured: 6 healthy subjects (FEV(1) = 107% pred), 6 patients with Asthma (FEV(1) = 72% pred), and 6 patients with COPD (FEV(1) = 40% pred). The lung deposition of the radioactive-labeled drug was measured with a gamma camera. The lung deposition relative to the emitted dose was 31% for healthy subjects, 34% for asthmatics, and 35% for COPD patients. These data suggest a comparable lung deposition in the different populations. There was no significant correlation between lung function (FEV(1)) and lung deposition. The extrathoracic deposition was around 50%. The finding were that lung deposition of the inhaled Formoterol did not depend on lung function and the relative high values of lung deposition can be explained by the small particle size (0.8 microm) of the HFA-Formoterol-Formulation and the slow inhalation (30 L/min flow) used in this study. It can be concluded, that with this modern HFA drug formulation, the deposition is high, even in obstructed lungs.

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