复分解方案在立体控制合成某些官能化β-氨基酯和氮杂杂环中的应用。

IF 7 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical record Pub Date : 2023-09-27 DOI:10.1002/tcr.202300279

Anas Semghouli, Melinda Nonn, Attila M. Remete, Santos Fustero, Loránd Kiss

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引用次数: 0

摘要

在这篇报道中，我们的目的是深入了解复分解协议（ROM、RCM、RCEYM、CM、RRM）在合成各种氮杂环框架中的应用。由于β-氨基酸在肽化学和药物设计中具有很高的生物学潜力和重要性，我们的目的是通过上述复分解策略重点介绍这类化合物的合成过程和转化，重点是选择性、立体控制、底物导向效应或官能团耐受性。

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Application of Metathesis Protocols to the Stereocontrolled Synthesis of some Functionalized β-Amino Esters and Azaheterocycles

In this account our aim was to give an insight into the application of metathesis protocols (ROM, RCM, RCEYM, CM, RRM) for the synthesis of various azaheterocyclic frameworks. Due to the high biological potential and importance in peptide chemistry and drug design of β-amino acids our intention is to give a highlight on the synthetic procedures and transformation of these class of compounds with the above-mentioned metathesis strategies with emphasis on selectivity, stereocontrol, substrate-directing effect or functional group tolerance.

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.