新冠肺炎患者的神经精神结果和睡眠功能障碍:危险因素和机制。

IF 2.2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2023-01-01 Epub Date: 2023-09-27 DOI:10.1159/000533722
Aliki Karkala, Asterios Tzinas, Seraphim Kotoulas, Athanasios Zacharias, Evdokia Sourla, Athanasia Pataka
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引用次数: 0

摘要

新型严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)导致的持续全球健康危机严重影响了生活的方方面面。尽管大多数关于SARS-CoV-2(新冠肺炎)引起的冠状病毒疾病的早期研究都集中在病毒的生理影响上,但大量后续研究表明,感染的心理负担也相当大。即使没有精神病史的患者,在新冠肺炎感染期间或之后,也更容易出现精神健康和睡眠障碍。病毒性神经变性和破坏血脑屏障的炎症风暴已被认为是心理健康表现的可能机制,以及应激性心理因素和血栓形成和缺氧的间接后果。该病毒已被发现感染外周嗅觉神经元并利用轴突迁移途径,在星形胶质细胞中表现出代谢变化,不利于为神经元提供能量和构建神经递质。新冠肺炎患者出现免疫反应失调和过度活跃,导致神经元功能和生存能力受损,对睡眠和情绪调节产生不利影响。此外,一些风险因素与感染的神经精神后遗症有关,如女性、年龄、先前存在的神经病理学、初始疾病的严重程度和社会学状况。这篇综述旨在概述2019冠状病毒病期间出现的心理健康症状和睡眠障碍,并分析心理困扰和睡眠功能障碍的潜在机制和风险因素。
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Neuropsychiatric Outcomes and Sleep Dysfunction in COVID-19 Patients: Risk Factors and Mechanisms.

The ongoing global health crisis due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has significantly impacted all aspects of life. While the majority of early research following the coronavirus disease caused by SARS-CoV-2 (COVID-19) has focused on the physiological effects of the virus, a substantial body of subsequent studies has shown that the psychological burden of the infection is also considerable. Patients, even without mental illness history, were at increased susceptibility to developing mental health and sleep disturbances during or after the COVID-19 infection. Viral neurotropism and inflammatory storm damaging the blood-brain barrier have been proposed as possible mechanisms for mental health manifestations, along with stressful psychological factors and indirect consequences such as thrombosis and hypoxia. The virus has been found to infect peripheral olfactory neurons and exploit axonal migration pathways, exhibiting metabolic changes in astrocytes that are detrimental to fueling neurons and building neurotransmitters. Patients with COVID-19 present dysregulated and overactive immune responses, resulting in impaired neuronal function and viability, adversely affecting sleep and emotion regulation. Additionally, several risk factors have been associated with the neuropsychiatric sequelae of the infection, such as female sex, age, preexisting neuropathologies, severity of initial disease and sociological status. This review aimed to provide an overview of mental health symptoms and sleep disturbances developed during COVID-19 and to analyze the underlying mechanisms and risk factors of psychological distress and sleep dysfunction.

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来源期刊
Neuroimmunomodulation
Neuroimmunomodulation 医学-免疫学
CiteScore
3.60
自引率
4.20%
发文量
35
审稿时长
>12 weeks
期刊介绍: The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.
期刊最新文献
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