ARRIVE指南发布12年后:动物研究尚未达到高标准。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Laboratory Animals Pub Date : 2024-04-01 Epub Date: 2023-09-20 DOI:10.1177/00236772231181658
Junmin Song, Marco Solmi, Andre F Carvalho, Jae Il Shin, John Pa Ioannidis
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引用次数: 0

摘要

动物研究的再现性危机危及动物研究的主要发现的可信度,尽管这些发现对人类研究至关重要。为了澄清和提高动物研究的透明度,ARRIVE报告指南于2010年首次公布,并于2020年升级至2.0版。然而,对这些报告准则的遵守和认识仍然不够理想。期刊编辑应该鼓励作者遵守这些准则。在评估和评估动物研究的方法和结果时,作者、编辑、推荐人和评审员应了解ARRIVE指南2.0。然而,我们也应该质疑单独的报告指南是否可以改变研究文化并提高动物研究的可重复性。报道的研究可能无法反映实际研究。由于设计选择不当,以及未发表而非次优报告,动物研究工作的大部分都被浪费了。对科学工作者进行更好的培训,在设计阶段采取干预措施改善动物研究,注册实践,以及将奖励制度与严格的动物研究的出版相结合,可能不仅仅是报告指南。
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Twelve years after the ARRIVE guidelines: Animal research has not yet arrived at high standards.

The reproducibility crisis across animal studies jeopardizes the credibility of the main findings derived from animal research, even though these findings are critical for informing human studies. To clarify and improve transparency among animal studies, the ARRIVE reporting guidelines were first announced in 2010 and upgraded to version 2.0 in 2020. However, compliance with and awareness of those reporting guidelines has remained suboptimal. Journal editors should encourage the authors to adhere to those guidelines. Authors, editors, referees, and reviewers should be aware of the ARRIVE guideline 2.0 when assessing and evaluating the methodology and findings of animal studies. However, we should also question whether reporting guidelines alone can change a research culture and improve the reproducibility of animal investigations. Reported research may not reflect actual research. Large segments of animal research efforts are wasted because of poor design choices and because of non-publication rather than suboptimal reporting. Better training of the scientific workforce, interventions at improving animal research at the design stage, registration practices, and alignment of the reward system with the publication of rigorous animal research may achieve more than reporting guidelines alone.

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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
期刊最新文献
An innovative approach for health and safety training and occupational health program annual enrollment for laboratory animal care and use personnel. Extended oxygen supplementation after thoracotomy in rats may improve welfare. Animal researchers' views on the publication of negative results and subsequent policy adoptions. Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis). Single nucleotide polymorphism (SNP) characterisation of mouse inbred strains bred at MRC-National Institute for Medical Research.
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