自闭症谱系障碍家族性可能性增高的婴儿脑电图功能连接。

IF 6.3 1区 医学 Q1 GENETICS & HEREDITY Molecular Autism Pub Date : 2023-10-07 DOI:10.1186/s13229-023-00570-5
Christian O'Reilly, Scott Huberty, Stefon van Noordt, James Desjardins, Nicky Wright, Julie Scorah, Sara Jane Webb, Mayada Elsabbagh
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引用次数: 0

摘要

背景:许多研究报道,自闭症谱系障碍(ASD)与非典型的结构和功能连接有关。然而,我们对婴儿期这些差异的发展了解相对较少。方法:我们使用来自两个独立的婴儿兄弟姐妹队列的高密度脑电图(EEG)数据集来表征生命最初几年的神经发育偏差。在6个月和12个月大时,在典型(N = 92)或ASD可能性升高(N = 90),由患有ASD的年长兄弟姐妹的存在来确定。我们使用相位锁定值的校正虚部计算了视频观看过程中EEG皮层源之间的功能连接。结果:我们的主要分析发现,功能连接与ASD之间没有显著关联,仅对年龄、性别、年龄-性别互动和部位有显著影响。鉴于这些无效结果,我们进行了探索性分析,并在12个月时观察到,功能连接与ADOS校准的限制性和重复性行为严重程度评分(RRB)之间存在负相关。局限性:兄弟姐妹研究固有的ASD参与者的小样本限制了诊断组的比较。此外,鉴于二次探索性分析的结果更容易出现假阳性,因此只能将其视为需要进一步探索的潜在关系。结论:关于婴儿期脑电图功能连接与ASD之间的关系,这些结果是不确定的。探索性分析为RRB和功能连接之间的关系提供了初步支持,但这些初步观察结果需要在更大的样本上得到证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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EEG functional connectivity in infants at elevated familial likelihood for autism spectrum disorder.

Background: Many studies have reported that autism spectrum disorder (ASD) is associated with atypical structural and functional connectivity. However, we know relatively little about the development of these differences in infancy.

Methods: We used a high-density electroencephalogram (EEG) dataset pooled from two independent infant sibling cohorts, to characterize such neurodevelopmental deviations during the first years of life. EEG was recorded at 6 and 12 months of age in infants at typical (N = 92) or elevated likelihood for ASD (N = 90), determined by the presence of an older sibling with ASD. We computed the functional connectivity between cortical sources of EEG during video watching using the corrected imaginary part of phase-locking values.

Results: Our main analysis found no significant association between functional connectivity and ASD, showing only significant effects for age, sex, age-sex interaction, and site. Given these null results, we performed an exploratory analysis and observed, at 12 months, a negative correlation between functional connectivity and ADOS calibrated severity scores for restrictive and repetitive behaviors (RRB).

Limitations: The small sample of ASD participants inherent to sibling studies limits diagnostic group comparisons. Also, results from our secondary exploratory analysis should be considered only as potential relationships to further explore, given their increased vulnerability to false positives.

Conclusions: These results are inconclusive concerning an association between EEG functional connectivity and ASD in infancy. Exploratory analyses provided preliminary support for a relationship between RRB and functional connectivity specifically, but these preliminary observations need corroboration on larger samples.

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来源期刊
Molecular Autism
Molecular Autism GENETICS & HEREDITY-NEUROSCIENCES
CiteScore
12.10
自引率
1.60%
发文量
44
审稿时长
17 weeks
期刊介绍: Molecular Autism is a peer-reviewed, open access journal that publishes high-quality basic, translational and clinical research that has relevance to the etiology, pathobiology, or treatment of autism and related neurodevelopmental conditions. Research that includes integration across levels is encouraged. Molecular Autism publishes empirical studies, reviews, and brief communications.
期刊最新文献
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