儿童多发性硬化症的体力活动和功能限制:疲劳和抑郁是混淆变量吗?

IF 0.8 Q4 PEDIATRICS Journal of pediatric rehabilitation medicine Pub Date : 2023-09-30 DOI:10.3233/PRM-220081
E Morghen Sikes, Marcia Finlayson, Brenda Banwell, Ruth Ann Marrie, E Ann Yeh, Rob Motl
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引用次数: 0

摘要

目的:儿童多发性硬化症(MS)与功能限制的风险有关,功能限制定义为日常生活能力的降低。中度至剧烈的体力活动(MVPA)与频率较低、影响较小的功能限制有关,但疲劳和抑郁症状尚未被视为潜在的混杂变量。这项研究考察了疲劳和抑郁是否混淆了患有儿科MS的年轻人的MVPA和功能限制之间的联系。方法:参与者数据是从三项正在进行的观察性研究中积累的。合并样本包括65例儿科发病的MS(24男/41女,16±1.7岁)。分析了自我报告的MVPA、功能限制、抑郁和疲劳的数据。结果:MVPA与功能限制显著相关(r = 0.45),疲劳(r = -0.28)和抑郁症(r = -0.32)。功能限制与疲劳有关(r = -0.45)和抑郁症状(r = -0.53)。MVPA与功能限制显著相关(β= 0.27,p = 0.04),即使考虑到一般疲劳(β= 0.08,p = 0.64)和抑郁症状(β= -0.40,p = 0.03)。结论:在儿童多发性硬化症青年中,自我报告的MVPA与感知的功能局限性相关,与感知的疲劳和抑郁症状无关。
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Physical activity and functional limitations in pediatric multiple sclerosis: Are fatigue and depression confounding variables?

Purpose: Pediatric-onset multiple sclerosis (MS) is associated with risk for functional limitations defined as the perceived reduction in capacity for undertaking activities of daily living. Moderate-to-vigorous physical activity (MVPA) has been associated with less frequent and less impactful functional limitations, but the symptoms of fatigue and depression have not been considered as potential confounding variables. This study examined whether fatigue and depression confound the association between MVPA and functional limitations among youth with pediatric MS.

Methods: Participant data were accumulated from three ongoing observational studies. The combined sample included 65 cases of pediatric-onset MS (24 male/41 female, 16±1.7 years of age). Data on self-report MVPA, functional limitations, depression, and fatigue were analyzed.

Results: MVPA was significantly associated with functional limitations (r = 0.45), fatigue (r = -0.28), and depression (r = -0.32). Functional limitations were associated with fatigue (r = -0.45) and depressive symptoms (r = -0.53). MVPA was significantly correlated with functional limitations (β= 0.27, p = 0.04) even after accounting for general fatigue (β= 0.08, p = 0.64) and depressive symptoms (β= -0.40, p = 0.03) among those with pediatric MS.

Conclusion: Self-reported MVPA was associated with perceived functional limitations among youth with pediatric MS independent of perceived fatigue and depressive symptoms.

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CiteScore
2.30
自引率
5.30%
发文量
139
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