儿童肥胖及其指标的全基因组关联研究进展：范围界定综述和富集分析。

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2023-10-06 DOI:10.1111/ijpo.13077

Feixiang Zhou, Gang Tian, Yiran Cui, Simin He, Yan Yan

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引用次数: 0

摘要

背景：儿童肥胖及其指标的全基因组关联研究（GWAS）进展具有挑战性，儿童和成人的遗传研究存在差异。目的：阐明儿童肥胖GWAS的发展史及其指标，总结GWAS基因座。方法：从2005年1月1日至2022年10月19日，系统检索PubMed、Web of Science、Embase和GWAS目录数据库中与儿童BMI、体脂和肥胖的GWAS相关的文献。最近的基因被用作定位基因，以进行基因集分析，包括途径、组织和疾病的富集。结果：2007年至2021年间发表的20篇文章被纳入这一范围界定综述，其中确定了116个SNPs与儿童BMI（n = 50），体脂（n = 31）和肥胖（n = 35）。在16项研究中，研究人群为欧洲人，在3项研究中为非欧洲人（1项东亚人；1项美国人；1项墨西哥人），在一项研究中有跨性别血统。通过对儿童肥胖相关基因及其指标的富集分析，确定了几种富集途径、组织和疾病。结论：工具和方法的创新使GWAS能够更好地探索儿童和青少年肥胖的遗传特征。然而，与欧洲人口相比，美国、亚洲和非洲人口中的GWAS数量有限。

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Development of genome-wide association studies on childhood obesity and its indicators: A scoping review and enrichment analysis

Background

The progress of genome-wide association studies (GWAS) in childhood obesity and its indicators is challenging and there are differences in genetic studies in children and adults.

Objective

To illustrate the history of the development of GWAS in childhood obesity and its indicators and summarize the GWAS loci.

Methods

PubMed, Web of Science, Embase and GWAS Catalog databases were systematically searched from 1 January 2005 to 19 October 2022 for literature related to GWAS of childhood BMI, body fatness and obesity. The nearest genes were used as positional genes to perform gene set analyses including the enrichment of pathways, tissues and diseases.

Results

Twenty articles published between 2007 and 2021 were included in this scoping review, which identified 116 SNPs reaching genome-wide significance with childhood BMI (n = 50), body fatness (n = 31) and obesity (n = 35). The study populations were European in 16 studies, non-European in three studies (1 East Asian; 1 American; 1 Mexican) and trans-ancestry in one study. Several enriched pathways, tissues and diseases were identified through enrichment analysis of genes associated with childhood obesity and its indicators.

Conclusions

The innovations in tools and methods enable GWAS to better explore the genetic characteristics of obesity in children and adolescents. However, the number of GWAS in American, Asian and African populations is limited compared to the European population.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.