类风湿性关节炎和新冠肺炎肺炎的免疫抑制治疗引发的类Stronyloides过度感染综合征。

IF 2.4 Q3 INFECTIOUS DISEASES Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2023-10-05 DOI:10.1186/s40794-023-00201-0
Hasan Hamze, Teresa Tai, David Harris
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引用次数: 0

摘要

新冠肺炎大流行给全球带来了临床和公共卫生挑战。皮质类固醇的使用已成为一种循证实践,以减少严重新冠肺炎疾病中涉及的过度炎症过程。然而,这可能会导致寄生虫感染的重新激活,即使是在短时间内。我们报告了一例64岁的古巴出生的患者,他在类风湿性关节炎免疫抑制延长的背景下,用地塞米松治疗严重的新冠肺炎疾病后,死于斯氏藻过度感染综合征。临床医生应意识到作为严重新冠肺炎治疗和其他免疫抑制疗法并发症的strongyloidia病的风险。我们建议来自流行地区的患者或因前往流行地区而积累风险的患者进行经验性Strongyloides治疗,并使用皮质类固醇治疗严重的新冠肺炎疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Strongyloides hyperinfection syndrome precipitated by immunosuppressive therapy for rheumatoid arthritis and COVID-19 pneumonia.

The COVID-19 pandemic has posed clinical and public health challenges worldwide. The use of corticosteroids has become an evidence-based practice to reduce the hyperinflammatory process involved in severe COVID-19 disease. However, this can result in the reactivation of parasitic infestations, even with a short course. We report the case of a 64-year-old Cuban born patient who passed away from S. stercoralis hyperinfection syndrome following treatment with dexamethasone for severe COVID-19 disease on a background of prolonged immunosuppression for rheumatoid arthritis. Clinicians should be aware of the risk of strongyloidiasis as a complication of the treatment for severe COVID-19 and other immunosuppressive therapies. We recommend empiric Strongyloides treatment for those who are from, or who have accumulated risk by travelling to endemic areas, and are being treated with corticosteroids for severe COVID-19 disease.

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来源期刊
CiteScore
5.20
自引率
0.00%
发文量
25
审稿时长
17 weeks
期刊介绍: Tropical Diseases, Travel Medicine and Vaccines is an open access journal that considers basic, translational and applied research, as well as reviews and commentary, related to the prevention and management of healthcare and diseases in international travelers. Given the changes in demographic trends of travelers globally, as well as the epidemiological transitions which many countries are experiencing, the journal considers non-infectious problems including chronic disease among target populations of interest as well as infectious diseases.
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